Courses of Interest:

(http://ocw.mit.edu/OcwWeb/web/courses/courses/index.htm#top)

Biological Engineering

Macroepidemiology

(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-102Spring-2005/CourseHome/index.htm)

Course Description: This course presents a challenging multi-dimensional perspective on the causes of human disease and mortality. The course focuses on analyses of major causes of mortality in the US since 1900: cancer, cardiovascular and cerebrovascular diseases, diabetes, and infectious diseases.

Chemicals in the Environment: Toxicology and Public Health

(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-104JSpring-2005/CourseHome/index.htm)

Course Description: This course addresses the challenges of defining a relationship between exposure to environmental chemicals and human disease. Course topics include epidemiological approaches to understanding disease causation; biostatistical methods; evaluation of human exposure to chemicals, and their internal distribution, metabolism, reactions with cellular components, and biological effects; and qualitative and quantitative health risk assessment methods used in the U.S. as bases for regulatory decision-making.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-104JSpring-2005/LectureNotes/index.htm)

Systems Microbiology

(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-106JFall-2006/CourseHome/index.htm)

Course Description: This course covers introductory microbiology from a systems perspective, considering microbial diversity, population dynamics, and genomics. Emphasis is placed on the delicate balance between microbes and humans, and the changes that result in the emergence of infectious diseases and antimicrobial resistance. The case study approach covers such topics as vaccines, toxins, biodefense, and infections including Legionnaire’s disease, tuberculosis, Helicobacter pylori, and plague.

Lecture Notes: (http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-106JFall-2006/LectureNotes/index.htm)

Mechanisms of Drug Actions

(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-201Fall-2005/CourseHome/index.htm)

Course Description: This course covers the chemical and biological analysis of the metabolism and distribution of drugs, toxins and chemicals in animals and humans, and the mechanism by which they cause therapeutic and toxic responses. Metabolism and toxicity as a basis for drug development is also covered.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-201Fall-2005/LectureNotes/index.htm)

Molecular and Cellular Pathophysiology

(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-450Spring-2005/CourseHome/index.htm)

Course Description: This course focuses on the fundamentals of tissue and organ response to injury from a molecular and cellular perspective. There is a special emphasis on disease states that bridge infection, inflammation, immunity, and cancer. The systems approach to pathophysiology includes lectures, critical evaluation of recent scientific papers, and student projects and presentations.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-450Spring-2005/LectureNotes/index.htm)

Design of Medical Devices and Implants

(http://ocw.mit.edu/OcwWeb/Mechanical-Engineering/2-782JSpring-2006/CourseHome/index.htm)

Course Description: This design course targets the solution of clinical problems by use of implants and other medical devices. Topics include the systematic use of cell-matrix control volumes; the role of stress analysis in the design process; anatomic fit, shape and size of implants; selection of biomaterials; instrumentation for surgical implantation procedures; preclinical testing for safety and efficacy, including risk/benefit ratio assessment evaluation of clinical performance and design of clinical trials.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Mechanical-Engineering/2-782JSpring-2006/LectureNotes/index.htm)

Molecular Principles of Biomaterials

(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-462JSpring-2006/CourseHome/index.htm)

Course Description: This course covers the analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-462JSpring-2006/LectureNotes/index.htm)

Biology

Genetics

(http://ocw.mit.edu/OcwWeb/Biology/7-03Fall-2004/CourseHome/index.htm)

Course Description: This course discusses the principles of genetics with application to the study of biological function at the level of molecules, cells, and multicellular organisms, including humans. The topics include: structure and function of genes, chromosomes and genomes, biological variation resulting from recombination, mutation, and selection, population genetics, use of genetic methods to analyze protein function, gene regulation and inherited disease.

Lecture Notes: (http://ocw.mit.edu/OcwWeb/Biology/7-03Fall-2004/LectureNotes/index.htm)

Topics in Experimental Biology

(http://ocw.mit.edu/OcwWeb/Biology/7-18Fall-2005/CourseHome/index.htm)

Course Description: This independent experimental study course is designed to allow students with a strong interest in independent research to fulfill the project laboratory requirement for the Biology Department Program in the context of a research laboratory at MIT. The research should be a continuation of a previous project under the direction of a member of the Biology Department faculty.

This course provides instruction and practice in written and oral communication. Journal club discussions are used to help students evaluate and write scientific papers.

Lecture Notes: (http://ocw.mit.edu/OcwWeb/Biology/7-18Fall-2005/LectureNotes/index.htm)

Cellular Neurobiology

(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-09JSpring-2005/CourseHome/index.htm)

Course Description: This course serves as an introduction to the structure and function of the nervous system. Emphasis is placed on the cellular properties of neurons and other excitable cells. Topics covered include the structure and biophysical properties of excitable cells, synaptic transmission, neurochemistry, neurodevelopment, and the integration of information in simple systems and the visual system.

Lecture Notes: (http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-09JSpring-2005/LectureNotes/index.htm)

Ubiquitination: The Proteasome and Human Disease

(http://ocw.mit.edu/OcwWeb/Biology/7-340Fall-2004/CourseHome/index.htm)

Course Description: This seminar provides a deeper understanding of the post-translational mechanisms evolved by eukaryotic cells to target proteins for degradation. Students learn how proteins are recognized and degraded by specific machinery (the proteasome) through their previous tagging with another small protein, ubiquitin. Additional topics include principles of ubiquitin-proteasome function, its control of the most important cellular pathways, and the implication of this system in different human diseases. Finally, speculation on the novel techniques that arose from an increased knowledge of the ubiquitin-proteosome system and current applications in the design of new pharmacological agents to battle disease is also covered.

Lecture Notes: (http://ocw.mit.edu/OcwWeb/Biology/7-340Fall-2004/LectureNotes/index.htm)

Under the Radar Screen: How Bugs Trick Our Immune Defenses

(http://ocw.mit.edu/OcwWeb/Biology/7-340Spring-2007/CourseHome/index.htm)

Course Description: In this course, we will explore the specific ways by which microbes defeat our immune system and the molecular mechanisms that are under attack (phagocytosis, the ubiquitin/proteasome pathway, MHC I/II antigen presentation). Through our discussion and dissection of the primary research literature, we will explore aspects of host-pathogen interactions. We will particularly emphasize the experimental techniques used in the field and how to read and understand research data. Technological advances in the fight against microbes will also be discussed, with specific examples.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Biology/7-340Spring-2007/LectureNotes/index.htm)

The Radical Consequences of Respiration: Reactive Oxygen Species in Aging and Disease

(http://ocw.mit.edu/OcwWeb/Biology/7-343Fall-2007/CourseHome/index.htm)

Course Description: This course will start with a survey of basic oxygen radical biochemistry followed by a discussion of the mechanisms of action of cellular as well as dietary antioxidants. After considering the normal physiological roles of oxidants, we will examine the effects of elevated ROS and a failure of cellular redox capacity on the rate of organismal and cellular aging as well as on the onset and progression of several major diseases that are often age-related. Topics will include ROS-induced effects on stem cell regeneration, insulin resistance, heart disease, neurodegenerative disorders, and cancer. The role of antioxidants in potential therapeutic strategies for modulating ROS levels will also be discussed.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Biology/7-343Fall-2007/LectureNotes/index.htm)

Protein Folding Problem

(http://ocw.mit.edu/OcwWeb/Biology/7-88JFall-2007/CourseHome/index.htm)

Course Description: This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Biology/7-88JFall-2007/LectureNotes/index.htm)

Brain and Cognitive Sciences

Neuroscience and Behavior

(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-01Fall-2003/CourseHome/index.htm)

Course Description: This course covers the relation of structure and function at various levels of neuronal integration. Topics include functional neuroanatomy and neurophysiology, sensory and motor systems, centrally programmed behavior, sensory systems, sleep and dreaming, motivation and reward, emotional displays of various types, "higher functions" and the neocortex, and neural processes in learning and memory.

Audio Lectures: (http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-01Fall-2003/AudioLectures/index.htm)

Neural Basis of Learning and Memory

(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-03Fall-2007/CourseHome/index.htm)

Course Description: This course highlights the interplay between cellular and molecular storage mechanisms and the cognitive neuroscience of memory, with an emphasis on human and animal models of hippocampal mechanisms and function.

Selected Lectures Notes: (http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-03Fall-2007/LectureNotes/index.htm)

Neural Basis of Vision and Audition

(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-04Fall-2006/CourseHome/index.htm)

Course Description: This course examines the neural bases of visual and auditory processing for perception and sensorimotor control, focusing on physiological and anatomical studies of the mammalian nervous system as well as behavioral studies of animals and humans. Visual pattern, color and depth perception, auditory responses and speech coding, and spatial localization are studied.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-04Fall-2006/LectureNotes/index.htm)

Brain Mechanisms for Hearing and Speech

(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-722JFall-2005/CourseHome/index.htm)

Course Description: An advanced course covering anatomical, physiological, behavioral, and computational studies of the central nervous system relevant to speech and hearing. Students learn primarily by discussions of scientific papers on topics of current interest. Recent topics include cell types and neural circuits in the auditory brainstem, organization and processing in the auditory cortex, auditory reflexes and descending systems, functional imaging of the human auditory system, quantitative methods for relating neural responses to behavior, speech motor control, cortical representation of language, and auditory learning in songbirds.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-722JFall-2005/LectureNotes/index.htm)

Statistical Methods in Brain and Cognitive Science

(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-07Spring-2004/CourseHome/index.htm)

Course Description: This course emphasizes statistics as a powerful tool for studying complex issues in behavioral and biological sciences, and explores the limitations of statistics as a method of inquiry. The course covers descriptive statistics, probability and random variables, inferential statistics, and basic issues in experimental design. Techniques introduced include confidence intervals, t-tests, F-tests, regression, and analysis of variance. Assignments include a project in data analysis.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-07Spring-2004/LectureNotes/index.htm)

Human Memory and Learning

(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-081Human-Memory-and-LearningFall2002/CourseHome/index.htm)

Course Description: Surveys the literature on the cognitive and neural organization of human memory and learning. Includes consideration of working memory and executive control, episodic and semantic memory, and implicit forms of memory. Emphasizes integration of cognitive theory with recent insights from functional neuroimaging (e.g., fMRI and PET).

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-081Human-Memory-and-LearningFall2002/LectureNotes/index.htm)

Brain Structure and its Origins

(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-14Spring-2005/CourseHome/index.htm)

Course Description: This course covers major CNS structures with emphasis on systems being used as models for experimental studies of development and plasticity. Topics include basic patterns of connections in CNS, embryogenesis, PNS anatomy and development, process outgrowth and synaptogenesis, growth factors and cell survival, spinal and hindbrain anatomy, and development of regional specificity with an introduction to comparative anatomy and CNS evolution. A review of lab techniques (anatomy, tissue culture) is also covered as well as the trigeminal system, retinotectal system development, plasticity, regeneration, neocortex anatomy and development, the olfactory system, corpus striatum, brain transplants, the limbic system and hippocampal anatomy and plasticity.

Audio Lectures: (http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-14Spring-2005/AudioLectures/index.htm)

Animal Behavior

(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-20Fall-2005/CourseHome/index.htm)

Course Description: Most of the major categories of adaptive behavior can be seen in all animals. This course begins with the evolution of behavior, the driver of nervous system evolution, reviewed using concepts developed in ethology, sociobiology, other comparative studies, and in studies of brain evolution. The roles of various types of plasticity are considered, as well as foraging and feeding, defensive and aggressive behavior, courtship and reproduction, migration and navigation, social activities and communication, with contributions of inherited patterns and cognitive abilities. Both field and laboratory based studies are reviewed; and finally, human behavior is considered within the context of primate studies.

Audio Lectures: (http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-20Fall-2005/AudioLectures/index.htm)

Neural Coding and Perception of Sound

(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-723Spring-2005/CourseHome/index.htm)

Course Description: This course focuses on neural structures and mechanisms mediating the detection, localization and recognition of sounds. Discussions cover how acoustic signals are coded by auditory neurons, the impact of these codes on behavioral performance, and the circuitry and cellular mechanisms underlying signal transformations. Topics include temporal coding, neural maps and feature detectors, learning and plasticity, and feedback control. General principles are conveyed by theme discussions of auditory masking, sound localization, musical pitch, speech coding, and cochlear implants.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-723Spring-2005/LectureNotes/index.htm)

Introduction to Computational Neuroscience

(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-29JSpring-2004/CourseHome/index.htm)

Course Description: This course gives a mathematical introduction to neural coding and dynamics. Topics include convolution, correlation, linear systems, game theory, signal detection theory, probability theory, information theory, and reinforcement learning. Applications to neural coding, focusing on the visual system are covered, as well as Hodgkin-Huxley and other related models of neural excitability, stochastic models of ion channels, cable theory, and models of synaptic transmission.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-29JSpring-2004/LectureNotes/index.htm)

Neural Plasticity in Learning and Development

(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-301JNeural-Plasticity-in-Learning-and-DevelopmentSpring2002/CourseHome/index.htm)

Course Description: Roles of neural plasticity in learning and memory and in development of invertebrates and mammals. An in-depth critical analysis of current literature of molecular, cellular, genetic, electrophysiological, and behavioral studies. Discussion of original papers supplemented by introductory lectures.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-301JNeural-Plasticity-in-Learning-and-DevelopmentSpring2002/LectureNotes/index.htm)

Parkinson's Disease Workshop

(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-458Summer-2006/CourseHome/index.htm)

Course Description: Parkinson's disease (PD) is a chronic, progressive, degenerative disease of the brain that produces movement disorders and deficits in executive functions, working memory, visuospatial functions, and internal control of attention. It is named after James Parkinson (1755-1824), the English neurologist who described the first case.

This six-week summer workshop explored different aspects of PD, including clinical characteristics, structural neuroimaging, neuropathology, genetics, and cognitive function (mental status, cognitive control processes, working memory, and long-term declarative memory). The workshop did not take up the topics of motor control, nondeclarative memory, or treatment.

Lecture Notes: (http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-458Summer-2006/LectureNotes/index.htm)

Scene Understanding Symposium

(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-459Spring-2006/CourseHome/index.htm)

Course Description: What are the circuits, mechanisms and representations that permit the recognition of a visual scene from just one glance? In this one-day seminar on Scene Understanding, speakers from a variety of disciplines - neurophysiology, cognitive neuroscience, visual cognition, computational neuroscience and computer vision - will address a range of topics related to scene recognition, including natural image categorization, contextual effects on object recognition, and the role of attention in scene understanding and visual art. The goal is to encourage exchanges between researchers of all fields of brain sciences in the burgeoning field of scene understanding.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-459Spring-2006/LectureNotes/index.htm)

Statistical Learning Theory and Applications

(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-520Statistical-Learning-Theory-and-ApplicationsSpring2003/CourseHome/index.htm)

Course Description: Focuses on the problem of supervised learning from the perspective of modern statistical learning theory starting with the theory of multivariate function approximation from sparse data. Develops basic tools such as Regularization including Support Vector Machines for regression and classification. Derives generalization bounds using both stability and VC theory. Discusses topics such as boosting and feature selection. Examines applications in several areas: computer vision, computer graphics, text classification and bioinformatics.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-520Statistical-Learning-Theory-and-ApplicationsSpring2003/LectureNotes/index.htm)

Language Processing

(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-591JFall-2004/CourseHome/index.htm)

Course Description: This course is a seminar in real-time language comprehension. It considers models of sentence and discourse comprehension from the linguistic, psychology, and artificial intelligence literature, including symbolic and connectionist models. Topics include ambiguity resolution and linguistic complexity; the use of lexical, syntactic, semantic, pragmatic, contextual and prosodic information in language comprehension; the relationship between the computational resources available in working memory and the language processing mechanism; and the psychological reality of linguistic representations.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-591JFall-2004/LectureNotes/index.htm)

Psycholinguistics

(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-59JSpring-2005/CourseHome/index.htm)

Course Description: This course covers central topics in language processing, including: the structure of language; sentence, discourse, and morphological processing; storage and access of words in the mental dictionary; speech processing; the relationship between the computational resources available in working memory and the language processing mechanism; and ambiguity resolution. The course also considers computational modeling, including connectionist models; the relationship between language and thought; and issues in language acquisition including critical period phenomena, the acquisition of speech, and the acquisition of words. Experimental methodologies such as self-paced reading, eye-tracking, cross-modal priming, and neural imaging methods are also examined.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-59JSpring-2005/LectureNotes/index.htm)

Language Acquisition I

(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-601JLanguage-Acquisition-ISpring2002/CourseHome/index.htm)

Course Description: Lectures, reading, and discussion of current theory and data concerning the psychology and biology of language acquisition. Emphasizes learning of syntax and morphology, together with some discussion of phonology, and especially research relating grammatical theory and learnability theory to empirical studies of children.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-601JLanguage-Acquisition-ISpring2002/LectureNotes/index.htm)

Natural Language and the Computer Representation of Knowledge

(http://ocw.mit.edu/OcwWeb/Electrical-Engineering-and-Computer-Science/6-863JSpring2003/CourseHome/index.htm)

Course Description: Natural Language and the Computer Representation of Knowledge is a laboratory-oriented course on the theory and practice of building computer systems for human language processing, with an emphasis on the linguistic, cognitive, and engineering foundations for understanding their design.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Electrical-Engineering-and-Computer-Science/6-863JSpring2003/LectureNotes/index.htm)

Laboratory in Cognitive Science

(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-63Fall-2005/CourseHome/index.htm)

Course Description: Laboratory in Cognitive Science teaches principles of experimental methods in human perception and cognition, including design and statistical analysis. The course combines lectures and hands-on experimental exercises and requires an independent experimental project. Some experience in programming is desirable.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-63Fall-2005/LectureNotes/index.htm)

Introduction to Neural Networks

(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-641JSpring-2005/CourseHome/index.htm)

Course Description: This course explores the organization of synaptic connectivity as the basis of neural computation and learning. Perceptrons and dynamical theories of recurrent networks including amplifiers, attractors, and hybrid computation are covered. Additional topics include backpropagation and Hebbian learning, as well as models of perception, motor control, memory, and neural development.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-641JSpring-2005/LectureNotes/index.htm)

Computational Cognitive Science

(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-66JFall-2004/CourseHome/index.htm)

Course Description: This course is an introduction to computational theories of human cognition. Drawing on formal models from classic and contemporary artificial intelligence, students will explore fundamental issues in human knowledge representation, inductive learning and reasoning. What are the forms that our knowledge of the world takes? What are the inductive principles that allow us to acquire new knowledge from the interaction of prior knowledge with observed data? What kinds of data must be available to human learners, and what kinds of innate knowledge (if any) must they have?

Lecture Notes: (http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-66JFall-2004/LectureNotes/index.htm)

Special Topics: Genetics, Neurobiology, and Pathophysiology of Psychiatric Disorders

(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-914Fall-2008/CourseHome/index.htm)

Course Description: The key topics covered in this course are Bipolar Disorder, Psychosis, Schizophrenia, Genetics of Psychiatric Disorder, DISC1, Ca++ Signaling, Neurogenesis and Depression, Lithium and GSK3 Hypothesis, Behavioral Assays, CREB in Addiction and Depressive Behaviors, The GABA System-I, The GABA System-II, The Glutamate Hypothesis of Schizophrenia, The Dopamine Pathway and DARPP32.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-914Fall-2008/LectureNotes/index.htm)

Language and Mind

(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-98Language-and-MindJanuary-IAP-2003/CourseHome/index.htm)

Course Description: This course will address some fundamental questions regarding human language: (1) how language is represented in our minds; (2) how language is acquired by children; (3) how language is processed by adults; (4) the relationship between language and thought; (5) exploring how language is represented and processed using brain imaging methods; and (6) computational modeling of human language acquisition and processing.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-98Language-and-MindJanuary-IAP-2003/LectureNotes/index.htm)

Neuropharmacology

(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-98January-IAP-2009/CourseHome/index.htm)

Course Description: The neuropharmacology course will discuss the drug-induced changes in functioning of the nervous system. The specific focus of this course will be to provide a description of the cellular and molecular actions of drugs on synaptic transmission. This course will also refer to specific diseases of the nervous system and their treatment in addition to giving an overview of the techniques used for the study of neuropharmacology.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-98January-IAP-2009/LectureNotes/index.htm)

Health Sciences and Technology

Musculoskeletal Pathophysiology

(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-021January-IAP-2006/CourseHome/index.htm)

Course Description: This course covers the growth, development and structure of normal bone and joints, the biomechanics of bone connective tissues, and their response to stress, calcium and phosphate homeostasis. Additional topics include regulation by parathyroid hormone and vitamin D, the pathogenesis of metabolic bone diseases and diseases of connective tissues, joints and muscle with consideration of possible mechanisms and underlying metabolic derangements.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-021January-IAP-2006/LectureNotes/index.htm)

Principle and Practice of Human Pathology

(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-035Spring2003/CourseHome/index.htm)

Course Description: This course provides a comprehensive overview of human pathology with emphasis on mechanisms of disease and diagnostic medicine. Topics include:

•Cellular Mechanisms of Disease

•Molecular Pathology

•Pathology of Major Organ Systems

•Review of Diagnostic Tools from Traditional Surgical Pathology to Diagnostic Spectroscopy

•Functional and Molecular Imaging

•Molecular Diagnostics

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-035Spring2003/LectureNotes/index.htm)

Human Reproductive Biology

(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-071Fall-2005/CourseHome/index.htm)

Course Description: This course is designed to give the student a clear understanding of the pathophysiology of the menstrual cycle, fertilization, implantation, ovum growth development, differentiation and associated abnormalities. Disorders of fetal development including the principles of teratology and the mechanism of normal and abnormal parturition will be covered as well as the pathophysiology of the breast and disorders of lactation. Fetal asphyxia and its consequences will be reviewed with emphasis on the technology currently available for its detection. In addition the conclusion of the reproductive cycle, menopause, and the use of hormonal replacement will be covered.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-071Fall-2005/LectureNotes/index.htm)

Gastroenterology

(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-121Fall-2005/CourseHome/index.htm)

Course Description: The most recent knowledge of the anatomy, physiology, biochemistry, biophysics, and bioengineering of the gastrointestinal tract and the associated pancreatic, liver and biliary tract systems is presented and discussed. Gross and microscopic pathology and the clinical aspects of important gastroenterological diseases are then presented, with emphasis on integrating the molecular, cellular and pathophysiological aspects of the disease processes to their related symptoms and signs.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-121Fall-2005/LectureNotes/index.htm)

Principles of Pharmacology

(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-151Spring-2005/CourseHome/index.htm)

Course Description: The object of the course is to teach students an approach to the study of pharmacologic agents. It is not intended to be a review of the pharmacopoeia. The focus is on the basic principles of biophysics, biochemistry and physiology, as related to the mechanisms of drug action, biodistribution and metabolism. Topics covered include: mechanisms of drug action, dose-response relations, pharmacokinetics, drug delivery systems, drug metabolism, toxicity of pharmacological agents, drug interaction and substance abuse. Selected agents and classes of agents are examined in detail.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-151Spring-2005/LectureNotes/index.htm)

Cellular and Molecular Immunology

(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-176Fall-2005/CourseHome/index.htm)

Course Description: This course covers cells and tissues of the immune system, lymphocyte development, the structure and function of antigen receptors, the cell biology of antigen processing and presentation, including molecular structure and assembly of MHC molecules, the biology of cytokines, leukocyte-endothelial interactions, and the pathogenesis of immunologically mediated diseases.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-176Fall-2005/LectureNotes/index.htm)

2005

2002

Projects in Microscale Engineering for the Life Sciences

(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-410JSpring-2007/CourseHome/index.htm)

Course Description: This course is a project-based introduction to manipulating and characterizing cells and biological molecules using microfabricated tools. It is designed for first year undergraduate students.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-410JSpring-2007/LectureNotes/index.htm)

Statistical Physics in Biology

(http://ocw.mit.edu/OcwWeb/Physics/8-592JSpring-2005/CourseHome/index.htm)

Course Description: Statistical Physics in Biology is a survey of problems at the interface of statistical physics and modern biology. Topics include: bioinformatic methods for extracting information content of DNA; gene finding, sequence comparison, and phylogenetic trees; physical interactions responsible for structure of biopolymers; DNA double helix, secondary structure of RNA, and elements of protein folding; considerations of force, motion, and packaging; protein motors, membranes. We also look at collective behavior of biological elements, cellular networks, neural networks, and evolution.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Physics/8-592JSpring-2005/LectureNotes/index.htm)

Survival Skills for Researchers: The Responsible Conduct of Research

(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-502Survival-Skills-for-Researchers--The-Responsible-Conduct-of-ResearchSpring2003/CourseHome/index.htm)

Course Description: This course is designed to provide graduate students and postdoctoral associates with techniques that enhance both validity and responsible conduct in scientific practice. Lectures present practical steps for developing skills in scientific research and are combined with discussion of cases. The course covers study design, preparation of proposals and manuscripts, peer review, authorship, use of humans and non-human animals in research, allegations of misconduct, and intellectual property. Also discussed are mentoring relationships and career options. Aspects of responsible research conduct are integrated into lectures and case discussion as appropriate to the specific topic.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-502Survival-Skills-for-Researchers-The-Responsible-Conduct-of-ResearchSpring2003/LectureNotes/index.htm)

Genomics and Computational Biology

(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-508Genomics-and-Computational-BiologyFall2002/CourseHome/index.htm)

Course Description: This course will assess the relationships among sequence, structure, and function in complex biological networks as well as progress in realistic modeling of quantitative, comprehensive, functional genomics analyses. Exercises will include algorithmic, statistical, database, and simulation approaches and practical applications to medicine, biotechnology, drug discovery, and genetic engineering. Future opportunities and current limitations will be critically addressed.

Lecture Notes (Audio available): (http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-508Genomics-and-Computational-BiologyFall2002/LectureNotes/index.htm)

Quantitative Genomics

(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-508Fall-2005/CourseHome/index.htm)

Course Description: This course provides a foundation in the following four areas: evolutionary and population genetics; comparative genomics; structural genomics and proteomics; and functional genomics and regulation.

Selected Lecture Notes: (http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-508Fall-2005/LectureNotes/index.htm)

Genomics and Computational Biology

(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-508-genomics-and-computational-biology-fall-2002/)

Course Description: This course will assess the relationships among sequence, structure, and function in complex biological networks as well as progress in realistic modeling of quantitative, comprehensive, functional genomics analyses. Exercises will include algorithmic, statistical, database, and simulation approaches and practical applications to medicine, biotechnology, drug discovery, and genetic engineering. Future opportunities and current limitations will be critically addressed.

Lecture Notes (Audio Lectures also available): (http://ocw.mit.edu/courses/health-sciences-and-technology/hst-508-genomics-and-computational-biology-fall-2002/lecture-notes/)

Genomics, Computing, Economics, and Society

(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-510-genomics-computing-economics-and-society-fall-2005/)

Course Description: This course will focus on understanding aspects of modern technology displaying exponential growth curves and the impact on global quality of life through a weekly updated class project integrating knowledge and providing practical tools for political and business decision-making concerning new aspects of bioengineering, personalized medicine, genetically modified organisms, and stem cells. Interplays of economic, ethical, ecological, and biophysical modeling will be explored through multi-disciplinary teams of students, and individual brief reports.

Lecture Notes: (http://ocw.mit.edu/courses/health-sciences-and-technology/hst-510-genomics-computing-economics-and-society-fall-2005/lecture-notes/)

Genomic Medicine

(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-512-genomic-medicine-spring-2004/)

Course Description: This course reviews the key genomic technologies and computational approaches that are driving advances in prognostics, diagnostics, and treatment. Throughout the semester, emphasis will return to issues surrounding the context of genomics in medicine including: what does a physician need to know? what sorts of questions will s/he likely encounter from patients? how should s/he respond? Lecturers will guide the student through real world patient-doctor interactions. Outcome considerations and socioeconomic implications of personalized medicine are also discussed. The first part of the course introduces key basic concepts of molecular biology, computational biology, and genomics. Continuing in the informatics applications portion of the course, lecturers begin each lecture block with a scenario, in order to set the stage and engage the student by showing: why is this important to know? how will the information presented be brought to bear on medical practice? The final section presents the ethical, legal, and social issues surrounding genomic medicine. A vision of how genomic medicine relates to preventative care and public health is presented in a discussion forum with the students where the following questions are explored: what is your level of preparedness now? what challenges must be met by the healthcare industry to get to where it needs to be?

Audio Lectures (Selected Lecture Notes also available): (http://ocw.mit.edu/courses/health-sciences-and-technology/hst-512-genomic-medicine-spring-2004/lecture-notes/)

Biomaterials-Tissue Interactions

(http://ocw.mit.edu/courses/biological-engineering/20-441-biomaterials-tissue-interactions-be-441-fall-2003/)

Course Description: This course is an introduction to principles of materials science and cell biology underlying the design of medical implants, artificial organs, and matrices for tissue engineering. Topics include methods for biomaterials surface characterization and analysis of protein adsorption on biomaterials. Molecular and cellular interactions with biomaterials are analyzed in terms of unit cell processes, such as matrix synthesis, degradation, and contraction. It also covers mechanisms underlying wound healing and tissue remodeling following implantation in various organs. Other areas include tissue and organ regeneration; design of implants and prostheses based on control of biomaterials-tissue interactions; comparative analysis of intact, biodegradable, and bioreplaceable implants by reference to case studies. Also addressed are criteria for restoration of physiological function for tissues and organs.

Selected Lecture Notes: (http://ocw.mit.edu/courses/biological-engineering/20-441-biomaterials-tissue-interactions-be-441-fall-2003/lecture-notes/)

Cell-Matrix Mechanics

(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-523j-cell-matrix-mechanics-spring-2004/)

Course Description: Mechanical forces play a decisive role during development of tissues and organs, during remodeling following injury as well as in normal function. A stress field influences cell function primarily through deformation of the extracellular matrix to which cells are attached. Deformed cells express different biosynthetic activity relative to undeformed cells. The unit cell process paradigm combined with topics in connective tissue mechanics form the basis for discussions of several topics from cell biology, physiology, and medicine.

Selected Lecture Notes: (http://ocw.mit.edu/courses/health-sciences-and-technology/hst-523j-cell-matrix-mechanics-spring-2004/lecture-notes/)

Tumor Pathophysiology and Transport Phenomena

(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-525j-tumor-pathophysiology-and-transport-phenomena-fall-2005/)

Course Description: Tumor pathophysiology plays a central role in the growth, invasion, metastasis and treatment of solid tumors. This class applies principles of transport phenomena to develop a systems-level, quantitative understanding of angiogenesis, blood flow and microcirculation, metabolism and microenvironment, transport and binding of small and large molecules, movement of cancer and immune cells, metastatic process, and treatment response.

Selected Lecture Notes: (http://ocw.mit.edu/courses/health-sciences-and-technology/hst-525j-tumor-pathophysiology-and-transport-phenomena-fall-2005/lecture-notes/)

()

Course Description:

Selected Lecture Notes: ()

()

Course Description:

Selected Lecture Notes: ()

()

Course Description:

Selected Lecture Notes: ()

()

Course Description:

Selected Lecture Notes: ()

()

Course Description:

Selected Lecture Notes: ()

()

Course Description:

Selected Lecture Notes: ()

()

Course Description:

Selected Lecture Notes: ()

()

Course Description:

Selected Lecture Notes: ()