Hoer_mit Open Courseware last modified by Gillian Stevens (t0022212) on 09 June 2010 3:47:55 PM

Courses of Interest:

(external link: http://ocw.mit.edu/OcwWeb/web/courses/courses/index.htm#top)

Biological Engineering

Macroepidemiology

(external link: http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-102Spring-2005/CourseHome/index.htm)

Course Description: This course presents a challenging multi-dimensional perspective on the causes of human disease and mortality. The course focuses on analyses of major causes of mortality in the US since 1900: cancer, cardiovascular and cerebrovascular diseases, diabetes, and infectious diseases.

Chemicals in the Environment: Toxicology and Public Health

(external link: http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-104JSpring-2005/CourseHome/index.htm)

Course Description: This course addresses the challenges of defining a relationship between exposure to environmental chemicals and human disease. Course topics include epidemiological approaches to understanding disease causation; biostatistical methods; evaluation of human exposure to chemicals, and their internal distribution, metabolism, reactions with cellular components, and biological effects; and qualitative and quantitative health risk assessment methods used in the U.S. as bases for regulatory decision-making.

Selected Lecture Notes: (external link: http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-104JSpring-2005/LectureNotes/index.htm)

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Introductory LectureWatch film A Civil ActionFrom the Real World to Hollywood and Back AgainEpidemiology: Persons, Places, and TimeEpidemiology: Test Development and Relative RiskBiostatistics: Concepts in Variance
Biostatistics: Distribution and the MeanConfidence IntervalsBiostatistics: Detecting Differences and CorrelationsBiostatistics: Poisson Analyses and PowerEnvironetics: Cause and EffectEnvironetics: Study Design - Retrospective versus Prospective
Environetics: Putting it all together - Evaluating StudiesEvaluating Environmental Causes of MesotheliomaQuantitative Risk Assessment 1Quantitative Risk Assessment 2Toxicology 1Toxicology 2
Toxicology 3Toxicology 4Toxicology 5Quantitative Risk Assessment 3Quantitative Risk Assessment 4 

Systems Microbiology

(external link: http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-106JFall-2006/CourseHome/index.htm)

Course Description: This course covers introductory microbiology from a systems perspective, considering microbial diversity, population dynamics, and genomics. Emphasis is placed on the delicate balance between microbes and humans, and the changes that result in the emergence of infectious diseases and antimicrobial resistance. The case study approach covers such topics as vaccines, toxins, biodefense, and infections including Legionnaire’s disease, tuberculosis, Helicobacter pylori, and plague.

Lecture Notes: (external link: http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-106JFall-2006/LectureNotes/index.htm)

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Early Earth/Microbial EvolutionCell Structure/FunctionBiological Energy ConservationMicrobial GrowthMetabolic RegulationVirology
Information Flow in Biological SystemsRegulation of Cell ActivityGenetic Exchange in BacteriaExperimental Evolution: Optimization of Metabolic SystemsGenomics IGenomics II
Metabolic Diversity IMetabolic Diversity IIMicrobial EcologyMicrobial Growth ControlMicrobe-host InteractionsImmunology I
Immunology IIDiagnostic MicrobiologyPerson-to-person TransmissionEpidemiologyAnimal- and Arthropod-transmitted DiseasesReview

Mechanisms of Drug Actions

(external link: http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-201Fall-2005/CourseHome/index.htm)

Course Description: This course covers the chemical and biological analysis of the metabolism and distribution of drugs, toxins and chemicals in animals and humans, and the mechanism by which they cause therapeutic and toxic responses. Metabolism and toxicity as a basis for drug development is also covered.

Selected Lecture Notes: (external link: http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-201Fall-2005/LectureNotes/index.htm)

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Introduction and PrinciplesChemistry/Biochemistry ReviewOverview of Drug DevelopmentUptake/Transport/Distribution of DrugsDrug TransportersBioethics Seminar
Drug Transporters (cont.)Introduction to Drug MetabolismLiver LectureDrug Metabolism 2Drug Metabolism 3Drug Metabolism 4 
Oxygen Radicals in Drug ToxicityDrug ToxicitiesDrug Toxicities (cont.)Bioethics SeminarPharmacokineticsPharmacokinetics (cont.)
Receptors and Case Study - OmeprazoleCase Study - OmeprazoleCase Study - Omeprazole (cont.)Case Study - AcetaminophenCase Study - Acetaminophen (cont.)Case Study - Statins
Case Study - Statins (cont.)Drug Industry SeminarCase Study - Statins (cont.)   

Molecular and Cellular Pathophysiology

(external link: http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-450Spring-2005/CourseHome/index.htm)

Course Description: This course focuses on the fundamentals of tissue and organ response to injury from a molecular and cellular perspective. There is a special emphasis on disease states that bridge infection, inflammation, immunity, and cancer. The systems approach to pathophysiology includes lectures, critical evaluation of recent scientific papers, and student projects and presentations.

Selected Lecture Notes: (external link: http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-450Spring-2005/LectureNotes/index.htm)

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Introduction to 20.450 and HCCCellular PathologyInflammationLiver Anatomy and HistologyImmunityNeoplasia
Neoplasia (cont.)Infectious DiseasesLiver and BiliaryHepatocarcinogenesisAnimal ModelsSpecial Topic

Design of Medical Devices and Implants

(external link: http://ocw.mit.edu/OcwWeb/Mechanical-Engineering/2-782JSpring-2006/CourseHome/index.htm)

Course Description: This design course targets the solution of clinical problems by use of implants and other medical devices. Topics include the systematic use of cell-matrix control volumes; the role of stress analysis in the design process; anatomic fit, shape and size of implants; selection of biomaterials; instrumentation for surgical implantation procedures; preclinical testing for safety and efficacy, including risk/benefit ratio assessment evaluation of clinical performance and design of clinical trials.

Selected Lecture Notes: (external link: http://ocw.mit.edu/OcwWeb/Mechanical-Engineering/2-782JSpring-2006/LectureNotes/index.htm)

I. Principles Of Implant Design (Working Paradigms)

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Clinical Problems Requiring Implants for SolutionPrinciples of Implant Design / Design Parameters: Permanent versus Absorbable DevicesThe Missing Organ and its ReplacementCriteria for Materials SelectionTissue Engineering I: ScaffoldsTissue Engineering II: Cells and Regulators
Case Study of Organ Regeneration     

II. Design Parameters

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Design Specifications: Biomaterials SurveyBiocompatibility: Local and Systemic EffectsDesign Specifications: Tissue Bonding and Modulus MatchingDegradation of Devices: Natural and Synthetic PolymersBiocompatibility: Scar Formation and ContractionDegradation of Devices: Corrosion and Wear
Federal Regulation of Devices IOral Presentations of Proposals for Design IIFederal Regulation of Devices II   

III. Design Solution In-use

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Scaffolds for Cartilage RepairImplants for BoneImplants for Plastic SurgeryCardiovascular Prostheses: Heart Valves and Blood VesselsDevices for Nerve RegenerationMusculoskeletal Soft Tissues: Meniscus, Intervertebral Disk
Dental and Otologic ImplantsOther Devices: Spinal Cord, Heart LungFinal Oral Presentation of Designs (Mock FDA Panel)   

Molecular Principles of Biomaterials

(external link: http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-462JSpring-2006/CourseHome/index.htm)

Course Description: This course covers the analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces.

Selected Lecture Notes: (external link: http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-462JSpring-2006/LectureNotes/index.htm)

Column1Column2Column3Column4Column5Column6
Biodegradable Polymeric SolidsBiodegradable Polymeric SolidsControlled Release DevicesControlled Release Devices (cont.)Case Studies in Complex Controlled ReleaseHydrogels as Biomaterials
Hydrogels as Biomaterials (cont.)Hydrogels as Biomaterials (cont.)Hydrogels as Biomaterials (cont.)Hydrogels as Biomaterials (cont.)Engineering Biological Recognition of BiomaterialsEngineering Biological Recognition of Biomaterials (cont.)
Engineering Biological Recognition of Biomaterials (cont.)Bioceramics and BiocompositesBioceramics and Biocomposites (cont.)Bioceramics and Biocomposites (cont.)Molecular DevicesNanoparticle and Microparticle Biomolecule Drug Carriers
Nanoparticle and Microparticle Biomolecule Drug Carriers (cont.)Basic Biology of Vaccination and Viral InfectionsBasic Biology of Vaccination and Viral Infections (cont.)Drug Targeting and Intracellular Drug Delivery for VaccinesDrug Targeting and Intracellular Drug Delivery for Vaccines (cont.)DNA Vaccines
DNA Vaccines (cont.)     

Biology

Genetics

(external link: http://ocw.mit.edu/OcwWeb/Biology/7-03Fall-2004/CourseHome/index.htm)

Course Description: This course discusses the principles of genetics with application to the study of biological function at the level of molecules, cells, and multicellular organisms, including humans. The topics include: structure and function of genes, chromosomes and genomes, biological variation resulting from recombination, mutation, and selection, population genetics, use of genetic methods to analyze protein function, gene regulation and inherited disease.

Lecture Notes: (external link: http://ocw.mit.edu/OcwWeb/Biology/7-03Fall-2004/LectureNotes/index.htm)

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Physical Structure of the GeneThe Complementation Test and Gene FunctionMendelian GeneticsProbability and PedigreesChromosomes and Sex LinkageRecombination and Genetic Maps
Three-factor CrossesTetrad AnalysisPhage GeneticsGene Structure and DNA AnalysisMutations and SuppressorsBacterial Genetics: Transposition
Bacterial Genetics: TransductionComplementation in Bacteria: PlasmidsComplementation in Bacteria: Recombinant DNAProkaryotic Regulation: Negative ControlProkaryotic Regulation: Positive ControlProkaryotic Regulation: Regulatory Circuits
Eukaryotic Genes and Genomes IEukaryotic Genes and Genomes IIEukaryotic Genes and Genomes IIIEukaryotic Genes and Genomes IVTransgenes and Gene Targeting in Mice ITransgenes and Gene Targeting in Mice II
Population Genetics: Hardy-WeinbergPopulation Genetics: Mutation and SelectionPopulation Genetics: InbreedingHuman PolymorphismsStatistical Evaluation of Linkage IStatistical Evaluation of Linkage II
Complex TraitsChromosome Anomalies IChromosome Anomalies IIGenetics of Cancer IGenetics of Cancer II  

Topics in Experimental Biology

(external link: http://ocw.mit.edu/OcwWeb/Biology/7-18Fall-2005/CourseHome/index.htm)

Course Description: This independent experimental study course is designed to allow students with a strong interest in independent research to fulfill the project laboratory requirement for the Biology Department Program in the context of a research laboratory at MIT. The research should be a continuation of a previous project under the direction of a member of the Biology Department faculty.

This course provides instruction and practice in written and oral communication. Journal club discussions are used to help students evaluate and write scientific papers.

Lecture Notes: (external link: http://ocw.mit.edu/OcwWeb/Biology/7-18Fall-2005/LectureNotes/index.htm)

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Impromptu Description of Research Project, Logic of a ParagraphLogic of a Research Paper, Organization of a Research Proposal, How to Present Data in a Lab TalkData and Figures, Results and Preliminary ResultsProject Outline and Journal ClubIntroduction, Background and SignificanceExperimental Plan
Discussion of Paragraphs, Ethical Conduct of Science, Citations and PlagiarismMethods and MaterialsScientific and Non-scientific AbstractDiscussion (cont.) and Polishing your Writing  

Cellular Neurobiology

(external link: http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-09JSpring-2005/CourseHome/index.htm)

Course Description: This course serves as an introduction to the structure and function of the nervous system. Emphasis is placed on the cellular properties of neurons and other excitable cells. Topics covered include the structure and biophysical properties of excitable cells, synaptic transmission, neurochemistry, neurodevelopment, and the integration of information in simple systems and the visual system.

Lecture Notes: (external link: http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-09JSpring-2005/LectureNotes/index.htm)

Column1Column2Column3Column4Column5Column6
Introduction to the Nervous SystemMembrane Channels and SignalingIonic basis of the Resting PotentialAction Potential IAction Potential IINeurons as Conductors: Propagation of the Action Potential
Electrical and Chemical Synaptic TransmissionMechanisms of Transmitter Release at SynapsesIndirect Mechanisms of Synaptic TransmissionBiochemistry of Synaptic TransmissionLearning and Memory ILearning and Memory II
From Genes to Structure to BehaviorNervous System Development INervous System Development IIAxon Guidance ISynapse FormationFine-Tuning Synaptic Connections
Vision IVision IIHearingOlfaction and Other Sensory SystemsPain and ThermoreceptionHigher Order Cognitive Function

Ubiquitination: The Proteasome and Human Disease

(external link: http://ocw.mit.edu/OcwWeb/Biology/7-340Fall-2004/CourseHome/index.htm)

Course Description: This seminar provides a deeper understanding of the post-translational mechanisms evolved by eukaryotic cells to target proteins for degradation. Students learn how proteins are recognized and degraded by specific machinery (the proteasome) through their previous tagging with another small protein, ubiquitin. Additional topics include principles of ubiquitin-proteasome function, its control of the most important cellular pathways, and the implication of this system in different human diseases. Finally, speculation on the novel techniques that arose from an increased knowledge of the ubiquitin-proteosome system and current applications in the design of new pharmacological agents to battle disease is also covered.

Lecture Notes: (external link: http://ocw.mit.edu/OcwWeb/Biology/7-340Fall-2004/LectureNotes/index.htm)

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IntroductionDiscovery of the Ubiquitin Conjugation SystemProtein Degradation in Trafficking Membranes I: Endoplasmic Reticulum Associated Degradation (ERAD) PathwayProtein Degradation in Trafficking Membranes II: Endocytosis and lysosomal DegradationRole of Ubiquitination in Transcriptional RegulationRole of Ubiquitination in Cell Cycle Control and Programmed Cell Death
Ubiquitin-like ProteinsFunctions of the Ubiquitin-Proteasome System in the Immune SystemUbiquitin and CancerUbiquitin and Neurodegenerative Diseases: Alzheimer's and Parkinson's DiseasesMore Diseases Involving Ubiquitin: Huntington's and Von Hippel-Lindau DiseaseToo Much Degradation Can Be as Bad as Not Enough: Cystic Fibrosis and Liddle's Syndrome
Potential Therapeutic Strategies in Ubiquitin-Related Diseases