Courses of Interest:
(
http://ocw.mit.edu/OcwWeb/web/courses/courses/index.htm#top)
Biological Engineering
Macroepidemiology
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-102Spring-2005/CourseHome/index.htm)
Course Description: This course presents a challenging multi-dimensional perspective on the causes of human disease and mortality. The course focuses on analyses of major causes of mortality in the US since 1900: cancer, cardiovascular and cerebrovascular diseases, diabetes, and infectious diseases.
Chemicals in the Environment: Toxicology and Public Health
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-104JSpring-2005/CourseHome/index.htm)
Course Description: This course addresses the challenges of defining a relationship between exposure to environmental chemicals and human disease. Course topics include epidemiological approaches to understanding disease causation; biostatistical methods; evaluation of human exposure to chemicals, and their internal distribution, metabolism, reactions with cellular components, and biological effects; and qualitative and quantitative health risk assessment methods used in the U.S. as bases for regulatory decision-making.
Selected Lecture Notes:
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-104JSpring-2005/LectureNotes/index.htm)
| Column1 | Column2 | Column3 | Column4 | Column5 | Column6 |
|---|---|---|---|---|---|
| Introductory Lecture | Watch film A Civil Action | From the Real World to Hollywood and Back Again | Epidemiology: Persons, Places, and Time | Epidemiology: Test Development and Relative Risk | Biostatistics: Concepts in Variance |
| Biostatistics: Distribution and the Mean | Confidence Intervals | Biostatistics: Detecting Differences and Correlations | Biostatistics: Poisson Analyses and Power | Environetics: Cause and Effect | Environetics: Study Design - Retrospective versus Prospective |
| Environetics: Putting it all together - Evaluating Studies | Evaluating Environmental Causes of Mesothelioma | Quantitative Risk Assessment 1 | Quantitative Risk Assessment 2 | Toxicology 1 | Toxicology 2 |
| Toxicology 3 | Toxicology 4 | Toxicology 5 | Quantitative Risk Assessment 3 | Quantitative Risk Assessment 4 |
Systems Microbiology
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-106JFall-2006/CourseHome/index.htm)
Course Description: This course covers introductory microbiology from a systems perspective, considering microbial diversity, population dynamics, and genomics. Emphasis is placed on the delicate balance between microbes and humans, and the changes that result in the emergence of infectious diseases and antimicrobial resistance. The case study approach covers such topics as vaccines, toxins, biodefense, and infections including Legionnaire’s disease, tuberculosis, Helicobacter pylori, and plague.
Lecture Notes:
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-106JFall-2006/LectureNotes/index.htm)
| Column1 | Column2 | Column3 | Column4 | Column5 | Column6 |
|---|---|---|---|---|---|
| Early Earth/Microbial Evolution | Cell Structure/Function | Biological Energy Conservation | Microbial Growth | Metabolic Regulation | Virology |
| Information Flow in Biological Systems | Regulation of Cell Activity | Genetic Exchange in Bacteria | Experimental Evolution: Optimization of Metabolic Systems | Genomics I | Genomics II |
| Metabolic Diversity I | Metabolic Diversity II | Microbial Ecology | Microbial Growth Control | Microbe-host Interactions | Immunology I |
| Immunology II | Diagnostic Microbiology | Person-to-person Transmission | Epidemiology | Animal- and Arthropod-transmitted Diseases | Review |
Mechanisms of Drug Actions
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-201Fall-2005/CourseHome/index.htm)
Course Description: This course covers the chemical and biological analysis of the metabolism and distribution of drugs, toxins and chemicals in animals and humans, and the mechanism by which they cause therapeutic and toxic responses. Metabolism and toxicity as a basis for drug development is also covered.
Selected Lecture Notes:
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-201Fall-2005/LectureNotes/index.htm)
| Column1 | Column2 | Column3 | Column4 | Column5 | Column6 | |
|---|---|---|---|---|---|---|
| Introduction and Principles | Chemistry/Biochemistry Review | Overview of Drug Development | Uptake/Transport/Distribution of Drugs | Drug Transporters | Bioethics Seminar | |
| Drug Transporters (cont.) | Introduction to Drug Metabolism | Liver Lecture | Drug Metabolism 2 | Drug Metabolism 3 | Drug Metabolism 4 | |
| Oxygen Radicals in Drug Toxicity | Drug Toxicities | Drug Toxicities (cont.) | Bioethics Seminar | Pharmacokinetics | Pharmacokinetics (cont.) | |
| Receptors and Case Study - Omeprazole | Case Study - Omeprazole | Case Study - Omeprazole (cont.) | Case Study - Acetaminophen | Case Study - Acetaminophen (cont.) | Case Study - Statins | |
| Case Study - Statins (cont.) | Drug Industry Seminar | Case Study - Statins (cont.) |
Molecular and Cellular Pathophysiology
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-450Spring-2005/CourseHome/index.htm)
Course Description: This course focuses on the fundamentals of tissue and organ response to injury from a molecular and cellular perspective. There is a special emphasis on disease states that bridge infection, inflammation, immunity, and cancer. The systems approach to pathophysiology includes lectures, critical evaluation of recent scientific papers, and student projects and presentations.
Selected Lecture Notes:
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-450Spring-2005/LectureNotes/index.htm)
| Column1 | Column2 | Column3 | Column4 | Column5 | Column6 |
|---|---|---|---|---|---|
| Introduction to 20.450 and HCC | Cellular Pathology | Inflammation | Liver Anatomy and Histology | Immunity | Neoplasia |
| Neoplasia (cont.) | Infectious Diseases | Liver and Biliary | Hepatocarcinogenesis | Animal Models | Special Topic |
Design of Medical Devices and Implants
(http://ocw.mit.edu/OcwWeb/Mechanical-Engineering/2-782JSpring-2006/CourseHome/index.htm)
Course Description: This design course targets the solution of clinical problems by use of implants and other medical devices. Topics include the systematic use of cell-matrix control volumes; the role of stress analysis in the design process; anatomic fit, shape and size of implants; selection of biomaterials; instrumentation for surgical implantation procedures; preclinical testing for safety and efficacy, including risk/benefit ratio assessment evaluation of clinical performance and design of clinical trials.
Selected Lecture Notes:
(http://ocw.mit.edu/OcwWeb/Mechanical-Engineering/2-782JSpring-2006/LectureNotes/index.htm)
I. Principles Of Implant Design (Working Paradigms)
| Column1 | Column2 | Column3 | Column4 | Column5 | Column6 |
|---|---|---|---|---|---|
| Clinical Problems Requiring Implants for Solution | Principles of Implant Design / Design Parameters: Permanent versus Absorbable Devices | The Missing Organ and its Replacement | Criteria for Materials Selection | Tissue Engineering I: Scaffolds | Tissue Engineering II: Cells and Regulators |
| Case Study of Organ Regeneration |
II. Design Parameters
| Column1 | Column2 | Column3 | Column4 | Column5 | Column6 |
|---|---|---|---|---|---|
| Design Specifications: Biomaterials Survey | Biocompatibility: Local and Systemic Effects | Design Specifications: Tissue Bonding and Modulus Matching | Degradation of Devices: Natural and Synthetic Polymers | Biocompatibility: Scar Formation and Contraction | Degradation of Devices: Corrosion and Wear |
| Federal Regulation of Devices I | Oral Presentations of Proposals for Design II | Federal Regulation of Devices II |
III. Design Solution In-use
| Column1 | Column2 | Column3 | Column4 | Column5 | Column6 |
|---|---|---|---|---|---|
| Scaffolds for Cartilage Repair | Implants for Bone | Implants for Plastic Surgery | Cardiovascular Prostheses: Heart Valves and Blood Vessels | Devices for Nerve Regeneration | Musculoskeletal Soft Tissues: Meniscus, Intervertebral Disk |
| Dental and Otologic Implants | Other Devices: Spinal Cord, Heart Lung | Final Oral Presentation of Designs (Mock FDA Panel) |