Page Differences: (Version 90 vs 91)

Version 90
(modified: 09 June 2010 1:03:55 PM by Gillian Stevens (t0022212)
Version 91
(modified: 09 June 2010 1:06:38 PM by Gillian Stevens (t0022212)
h1 Courses of Interest:h1 Courses of Interest:
(http://ocw.mit.edu/OcwWeb/web/courses/courses/index.htm#top)(http://ocw.mit.edu/OcwWeb/web/courses/courses/index.htm#top)
h2 Biological Engineeringh2 Biological Engineering
h3 Macroepidemiologyh3 Macroepidemiology
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-102Spring-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-102Spring-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course presents a challenging multi-dimensional perspective on the causes of human disease and mortality. The course focuses on analyses of major causes of mortality in the US since 1900: cancer, cardiovascular and cerebrovascular diseases, diabetes, and infectious diseases.This course presents a challenging multi-dimensional perspective on the causes of human disease and mortality. The course focuses on analyses of major causes of mortality in the US since 1900: cancer, cardiovascular and cerebrovascular diseases, diabetes, and infectious diseases.
h3 Chemicals in the Environment: Toxicology and Public Healthh3 Chemicals in the Environment: Toxicology and Public Health
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-104JSpring-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-104JSpring-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course addresses the challenges of defining a relationship between exposure to environmental chemicals and human disease. Course topics include epidemiological approaches to understanding disease causation; biostatistical methods; evaluation of human exposure to chemicals, and their internal distribution, metabolism, reactions with cellular components, and biological effects; and qualitative and quantitative health risk assessment methods used in the U.S. as bases for regulatory decision-making.This course addresses the challenges of defining a relationship between exposure to environmental chemicals and human disease. Course topics include epidemiological approaches to understanding disease causation; biostatistical methods; evaluation of human exposure to chemicals, and their internal distribution, metabolism, reactions with cellular components, and biological effects; and qualitative and quantitative health risk assessment methods used in the U.S. as bases for regulatory decision-making.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-104JSpring-2005/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-104JSpring-2005/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Introductory Lecture|Watch film A Civil Action|From the Real World to Hollywood and Back Again|Epidemiology: Persons, Places, and Time|Epidemiology: Test Development and Relative Risk|Biostatistics: Concepts in Variance Introductory Lecture|Watch film A Civil Action|From the Real World to Hollywood and Back Again|Epidemiology: Persons, Places, and Time|Epidemiology: Test Development and Relative Risk|Biostatistics: Concepts in Variance
Biostatistics: Distribution and the Mean|Confidence Intervals|Biostatistics: Detecting Differences and Correlations|Biostatistics: Poisson Analyses and Power|Environetics: Cause and Effect|Environetics: Study Design - Retrospective versus ProspectiveBiostatistics: Distribution and the Mean|Confidence Intervals|Biostatistics: Detecting Differences and Correlations|Biostatistics: Poisson Analyses and Power|Environetics: Cause and Effect|Environetics: Study Design - Retrospective versus Prospective
Environetics: Putting it all together - Evaluating Studies|Evaluating Environmental Causes of Mesothelioma|Quantitative Risk Assessment 1|Quantitative Risk Assessment 2|Toxicology 1|Toxicology 2Environetics: Putting it all together - Evaluating Studies|Evaluating Environmental Causes of Mesothelioma|Quantitative Risk Assessment 1|Quantitative Risk Assessment 2|Toxicology 1|Toxicology 2
Toxicology 3|Toxicology 4|Toxicology 5|Quantitative Risk Assessment 3|Quantitative Risk Assessment 4|Toxicology 3|Toxicology 4|Toxicology 5|Quantitative Risk Assessment 3|Quantitative Risk Assessment 4|
{table}{table}
h3 Systems Microbiologyh3 Systems Microbiology
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-106JFall-2006/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-106JFall-2006/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course covers introductory microbiology from a systems perspective, considering microbial diversity, population dynamics, and genomics. Emphasis is placed on the delicate balance between microbes and humans, and the changes that result in the emergence of infectious diseases and antimicrobial resistance. The case study approach covers such topics as vaccines, toxins, biodefense, and infections including Legionnaire’s disease, tuberculosis, Helicobacter pylori, and plague.This course covers introductory microbiology from a systems perspective, considering microbial diversity, population dynamics, and genomics. Emphasis is placed on the delicate balance between microbes and humans, and the changes that result in the emergence of infectious diseases and antimicrobial resistance. The case study approach covers such topics as vaccines, toxins, biodefense, and infections including Legionnaire’s disease, tuberculosis, Helicobacter pylori, and plague.
__Lecture Notes__:__Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-106JFall-2006/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-106JFall-2006/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Early Earth/Microbial Evolution|Cell Structure/Function|Biological Energy Conservation|Microbial Growth|Metabolic Regulation|VirologyEarly Earth/Microbial Evolution|Cell Structure/Function|Biological Energy Conservation|Microbial Growth|Metabolic Regulation|Virology
Information Flow in Biological Systems|Regulation of Cell Activity|Genetic Exchange in Bacteria|Experimental Evolution: Optimization of Metabolic Systems|Genomics I|Genomics IIInformation Flow in Biological Systems|Regulation of Cell Activity|Genetic Exchange in Bacteria|Experimental Evolution: Optimization of Metabolic Systems|Genomics I|Genomics II
Metabolic Diversity I|Metabolic Diversity II|Microbial Ecology|Microbial Growth Control|Microbe-host Interactions|Immunology IMetabolic Diversity I|Metabolic Diversity II|Microbial Ecology|Microbial Growth Control|Microbe-host Interactions|Immunology I
Immunology II|Diagnostic Microbiology|Person-to-person Transmission|Epidemiology|Animal- and Arthropod-transmitted Diseases|ReviewImmunology II|Diagnostic Microbiology|Person-to-person Transmission|Epidemiology|Animal- and Arthropod-transmitted Diseases|Review
{table}{table}
h3 Mechanisms of Drug Actionsh3 Mechanisms of Drug Actions
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-201Fall-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-201Fall-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course covers the chemical and biological analysis of the metabolism and distribution of drugs, toxins and chemicals in animals and humans, and the mechanism by which they cause therapeutic and toxic responses. Metabolism and toxicity as a basis for drug development is also covered.This course covers the chemical and biological analysis of the metabolism and distribution of drugs, toxins and chemicals in animals and humans, and the mechanism by which they cause therapeutic and toxic responses. Metabolism and toxicity as a basis for drug development is also covered.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-201Fall-2005/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-201Fall-2005/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Introduction and Principles|Chemistry/Biochemistry Review|Overview of Drug Development|Uptake/Transport/Distribution of Drugs|Drug Transporters|Bioethics SeminarIntroduction and Principles|Chemistry/Biochemistry Review|Overview of Drug Development|Uptake/Transport/Distribution of Drugs|Drug Transporters|Bioethics Seminar
Drug Transporters (cont.)|Introduction to Drug Metabolism|Liver Lecture|Drug Metabolism 2|Drug Metabolism 3|Drug Metabolism 4|Drug Transporters (cont.)|Introduction to Drug Metabolism|Liver Lecture|Drug Metabolism 2|Drug Metabolism 3|Drug Metabolism 4|
Oxygen Radicals in Drug Toxicity|Drug Toxicities|Drug Toxicities (cont.)|Bioethics Seminar|Pharmacokinetics|Pharmacokinetics (cont.)Oxygen Radicals in Drug Toxicity|Drug Toxicities|Drug Toxicities (cont.)|Bioethics Seminar|Pharmacokinetics|Pharmacokinetics (cont.)
Receptors and Case Study - Omeprazole|Case Study - Omeprazole|Case Study - Omeprazole (cont.)|Case Study - Acetaminophen|Case Study - Acetaminophen (cont.)|Case Study - StatinsReceptors and Case Study - Omeprazole|Case Study - Omeprazole|Case Study - Omeprazole (cont.)|Case Study - Acetaminophen|Case Study - Acetaminophen (cont.)|Case Study - Statins
Case Study - Statins (cont.)|Drug Industry Seminar|Case Study - Statins (cont.)|||Case Study - Statins (cont.)|Drug Industry Seminar|Case Study - Statins (cont.)|||
{table}{table}
h3 Molecular and Cellular Pathophysiologyh3 Molecular and Cellular Pathophysiology
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-450Spring-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-450Spring-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course focuses on the fundamentals of tissue and organ response to injury from a molecular and cellular perspective. There is a special emphasis on disease states that bridge infection, inflammation, immunity, and cancer. The systems approach to pathophysiology includes lectures, critical evaluation of recent scientific papers, and student projects and presentations.This course focuses on the fundamentals of tissue and organ response to injury from a molecular and cellular perspective. There is a special emphasis on disease states that bridge infection, inflammation, immunity, and cancer. The systems approach to pathophysiology includes lectures, critical evaluation of recent scientific papers, and student projects and presentations.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-450Spring-2005/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-450Spring-2005/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Introduction to 20.450 and HCC|Cellular Pathology|Inflammation|Liver Anatomy and Histology|Immunity|NeoplasiaIntroduction to 20.450 and HCC|Cellular Pathology|Inflammation|Liver Anatomy and Histology|Immunity|Neoplasia
Neoplasia (cont.)|Infectious Diseases|Liver and Biliary|Hepatocarcinogenesis|Animal Models|Special TopicNeoplasia (cont.)|Infectious Diseases|Liver and Biliary|Hepatocarcinogenesis|Animal Models|Special Topic
{table}{table}
h3 Design of Medical Devices and Implantsh3 Design of Medical Devices and Implants
(http://ocw.mit.edu/OcwWeb/Mechanical-Engineering/2-782JSpring-2006/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Mechanical-Engineering/2-782JSpring-2006/CourseHome/index.htm)
__Course Description__:__Course Description__:
This design course targets the solution of clinical problems by use of implants and other medical devices. Topics include the systematic use of cell-matrix control volumes; the role of stress analysis in the design process; anatomic fit, shape and size of implants; selection of biomaterials; instrumentation for surgical implantation procedures; preclinical testing for safety and efficacy, including risk/benefit ratio assessment evaluation of clinical performance and design of clinical trials.This design course targets the solution of clinical problems by use of implants and other medical devices. Topics include the systematic use of cell-matrix control volumes; the role of stress analysis in the design process; anatomic fit, shape and size of implants; selection of biomaterials; instrumentation for surgical implantation procedures; preclinical testing for safety and efficacy, including risk/benefit ratio assessment evaluation of clinical performance and design of clinical trials.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Mechanical-Engineering/2-782JSpring-2006/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Mechanical-Engineering/2-782JSpring-2006/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Clinical Problems Requiring Implants for Solution|Principles of Implant Design / Design Parameters: Permanent versus Absorbable Devices|The Missing Organ and its Replacement|Criteria for Materials Selection|Tissue Engineering I: Scaffolds|Tissue Engineering II: Cells and RegulatorsClinical Problems Requiring Implants for Solution|Principles of Implant Design / Design Parameters: Permanent versus Absorbable Devices|The Missing Organ and its Replacement|Criteria for Materials Selection|Tissue Engineering I: Scaffolds|Tissue Engineering II: Cells and Regulators
Case Study of Organ Regeneration|Design Specifications: Biomaterials Survey|Biocompatibility: Local and Systemic Effects|Design Specifications: Tissue Bonding and Modulus Matching|Degradation of Devices: Natural and Synthetic Polymers|Biocompatibility: Scar Formation and ContractionCase Study of Organ Regeneration|Design Specifications: Biomaterials Survey|Biocompatibility: Local and Systemic Effects|Design Specifications: Tissue Bonding and Modulus Matching|Degradation of Devices: Natural and Synthetic Polymers|Biocompatibility: Scar Formation and Contraction
Degradation of Devices: Corrosion and Wear|Federal Regulation of Devices I|Oral Presentations of Proposals for Design II|Federal Regulation of Devices II|Scaffolds for Cartilage Repair|Implants for BoneDegradation of Devices: Corrosion and Wear|Federal Regulation of Devices I|Oral Presentations of Proposals for Design II|Federal Regulation of Devices II|Scaffolds for Cartilage Repair|Implants for Bone
Implants for Plastic Surgery|Cardiovascular Prostheses: Heart Valves and Blood Vessels|Devices for Nerve Regeneration|Musculoskeletal Soft Tissues: Meniscus, Intervertebral Disk|Dental and Otologic Implants|Other Devices: Spinal Cord, Heart LungImplants for Plastic Surgery|Cardiovascular Prostheses: Heart Valves and Blood Vessels|Devices for Nerve Regeneration|Musculoskeletal Soft Tissues: Meniscus, Intervertebral Disk|Dental and Otologic Implants|Other Devices: Spinal Cord, Heart Lung
Final Oral Presentation of Designs (Mock FDA Panel)|||||Final Oral Presentation of Designs (Mock FDA Panel)|||||
{table}{table}
h3 Molecular Principles of Biomaterialsh3 Molecular Principles of Biomaterials
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-462JSpring-2006/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-462JSpring-2006/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course covers the analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces.This course covers the analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-462JSpring-2006/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-462JSpring-2006/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Biodegradable Polymeric Solids|Biodegradable Polymeric Solids|Controlled Release Devices|Controlled Release Devices (cont.)|Case Studies in Complex Controlled Release|Hydrogels as BiomaterialsBiodegradable Polymeric Solids|Biodegradable Polymeric Solids|Controlled Release Devices|Controlled Release Devices (cont.)|Case Studies in Complex Controlled Release|Hydrogels as Biomaterials
Hydrogels as Biomaterials (cont.)|Hydrogels as Biomaterials (cont.)|Hydrogels as Biomaterials (cont.)|Hydrogels as Biomaterials (cont.)|Engineering Biological Recognition of Biomaterials|Engineering Biological Recognition of Biomaterials (cont.)Hydrogels as Biomaterials (cont.)|Hydrogels as Biomaterials (cont.)|Hydrogels as Biomaterials (cont.)|Hydrogels as Biomaterials (cont.)|Engineering Biological Recognition of Biomaterials|Engineering Biological Recognition of Biomaterials (cont.)
Engineering Biological Recognition of Biomaterials (cont.)|Bioceramics and Biocomposites|Bioceramics and Biocomposites (cont.)|Bioceramics and Biocomposites (cont.)|Molecular Devices|Nanoparticle and Microparticle Biomolecule Drug CarriersEngineering Biological Recognition of Biomaterials (cont.)|Bioceramics and Biocomposites|Bioceramics and Biocomposites (cont.)|Bioceramics and Biocomposites (cont.)|Molecular Devices|Nanoparticle and Microparticle Biomolecule Drug Carriers
Nanoparticle and Microparticle Biomolecule Drug Carriers (cont.)|Basic Biology of Vaccination and Viral Infections|Basic Biology of Vaccination and Viral Infections (cont.)|Drug Targeting and Intracellular Drug Delivery for Vaccines|Drug Targeting and Intracellular Drug Delivery for Vaccines (cont.)|DNA VaccinesNanoparticle and Microparticle Biomolecule Drug Carriers (cont.)|Basic Biology of Vaccination and Viral Infections|Basic Biology of Vaccination and Viral Infections (cont.)|Drug Targeting and Intracellular Drug Delivery for Vaccines|Drug Targeting and Intracellular Drug Delivery for Vaccines (cont.)|DNA Vaccines
DNA Vaccines (cont.)|||||DNA Vaccines (cont.)|||||
{table}{table}
h2 Biologyh2 Biology
h3 Genetics h3 Genetics
(http://ocw.mit.edu/OcwWeb/Biology/7-03Fall-2004/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Biology/7-03Fall-2004/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course discusses the principles of genetics with application to the study of biological function at the level of molecules, cells, and multicellular organisms, including humans. The topics include: structure and function of genes, chromosomes and genomes, biological variation resulting from recombination, mutation, and selection, population genetics, use of genetic methods to analyze protein function, gene regulation and inherited disease.This course discusses the principles of genetics with application to the study of biological function at the level of molecules, cells, and multicellular organisms, including humans. The topics include: structure and function of genes, chromosomes and genomes, biological variation resulting from recombination, mutation, and selection, population genetics, use of genetic methods to analyze protein function, gene regulation and inherited disease.
__Lecture Notes__:__Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Biology/7-03Fall-2004/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Biology/7-03Fall-2004/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Physical Structure of the Gene|The Complementation Test and Gene Function|Mendelian Genetics|Probability and Pedigrees|Chromosomes and Sex Linkage|Recombination and Genetic MapsPhysical Structure of the Gene|The Complementation Test and Gene Function|Mendelian Genetics|Probability and Pedigrees|Chromosomes and Sex Linkage|Recombination and Genetic Maps
Three-factor Crosses|Tetrad Analysis|Phage Genetics|Gene Structure and DNA Analysis|Mutations and Suppressors|Bacterial Genetics: TranspositionThree-factor Crosses|Tetrad Analysis|Phage Genetics|Gene Structure and DNA Analysis|Mutations and Suppressors|Bacterial Genetics: Transposition
Bacterial Genetics: Transduction|Complementation in Bacteria: Plasmids|Complementation in Bacteria: Recombinant DNA|Prokaryotic Regulation: Negative Control|Prokaryotic Regulation: Positive Control|Prokaryotic Regulation: Regulatory CircuitsBacterial Genetics: Transduction|Complementation in Bacteria: Plasmids|Complementation in Bacteria: Recombinant DNA|Prokaryotic Regulation: Negative Control|Prokaryotic Regulation: Positive Control|Prokaryotic Regulation: Regulatory Circuits
Eukaryotic Genes and Genomes I|Eukaryotic Genes and Genomes II|Eukaryotic Genes and Genomes III|Eukaryotic Genes and Genomes IV|Transgenes and Gene Targeting in Mice I|Transgenes and Gene Targeting in Mice IIEukaryotic Genes and Genomes I|Eukaryotic Genes and Genomes II|Eukaryotic Genes and Genomes III|Eukaryotic Genes and Genomes IV|Transgenes and Gene Targeting in Mice I|Transgenes and Gene Targeting in Mice II
Population Genetics: Hardy-Weinberg|Population Genetics: Mutation and Selection|Population Genetics: Inbreeding|Human Polymorphisms|Statistical Evaluation of Linkage I|Statistical Evaluation of Linkage IIPopulation Genetics: Hardy-Weinberg|Population Genetics: Mutation and Selection|Population Genetics: Inbreeding|Human Polymorphisms|Statistical Evaluation of Linkage I|Statistical Evaluation of Linkage II
Complex Traits|Chromosome Anomalies I|Chromosome Anomalies II|Genetics of Cancer I|Genetics of Cancer II||Complex Traits|Chromosome Anomalies I|Chromosome Anomalies II|Genetics of Cancer I|Genetics of Cancer II||
{table}{table}
h3 Topics in Experimental Biologyh3 Topics in Experimental Biology
(http://ocw.mit.edu/OcwWeb/Biology/7-18Fall-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Biology/7-18Fall-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
This independent experimental study course is designed to allow students with a strong interest in independent research to fulfill the project laboratory requirement for the Biology Department Program in the context of a research laboratory at MIT. The research should be a continuation of a previous project under the direction of a member of the Biology Department faculty.This independent experimental study course is designed to allow students with a strong interest in independent research to fulfill the project laboratory requirement for the Biology Department Program in the context of a research laboratory at MIT. The research should be a continuation of a previous project under the direction of a member of the Biology Department faculty.
This course provides instruction and practice in written and oral communication. Journal club discussions are used to help students evaluate and write scientific papers.This course provides instruction and practice in written and oral communication. Journal club discussions are used to help students evaluate and write scientific papers.
__Lecture Notes__:__Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Biology/7-18Fall-2005/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Biology/7-18Fall-2005/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Impromptu Description of Research Project, Logic of a Paragraph|Logic of a Research Paper, Organization of a Research Proposal, How to Present Data in a Lab Talk|Data and Figures, Results and Preliminary Results|Project Outline and Journal Club|Introduction, Background and Significance|Experimental PlanImpromptu Description of Research Project, Logic of a Paragraph|Logic of a Research Paper, Organization of a Research Proposal, How to Present Data in a Lab Talk|Data and Figures, Results and Preliminary Results|Project Outline and Journal Club|Introduction, Background and Significance|Experimental Plan
Discussion of Paragraphs, Ethical Conduct of Science, Citations and Plagiarism|Methods and Materials|Scientific and Non-scientific Abstract|Discussion (cont.) and Polishing your Writing||Discussion of Paragraphs, Ethical Conduct of Science, Citations and Plagiarism|Methods and Materials|Scientific and Non-scientific Abstract|Discussion (cont.) and Polishing your Writing||
{table}{table}
h3 Cellular Neurobiologyh3 Cellular Neurobiology
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-09JSpring-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-09JSpring-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course serves as an introduction to the structure and function of the nervous system. Emphasis is placed on the cellular properties of neurons and other excitable cells. Topics covered include the structure and biophysical properties of excitable cells, synaptic transmission, neurochemistry, neurodevelopment, and the integration of information in simple systems and the visual system.This course serves as an introduction to the structure and function of the nervous system. Emphasis is placed on the cellular properties of neurons and other excitable cells. Topics covered include the structure and biophysical properties of excitable cells, synaptic transmission, neurochemistry, neurodevelopment, and the integration of information in simple systems and the visual system.
__Lecture Notes__:__Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-09JSpring-2005/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-09JSpring-2005/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Introduction to the Nervous System|Membrane Channels and Signaling|Ionic basis of the Resting Potential|Action Potential I|Action Potential II|Neurons as Conductors: Propagation of the Action PotentialIntroduction to the Nervous System|Membrane Channels and Signaling|Ionic basis of the Resting Potential|Action Potential I|Action Potential II|Neurons as Conductors: Propagation of the Action Potential
Electrical and Chemical Synaptic Transmission|Mechanisms of Transmitter Release at Synapses|Indirect Mechanisms of Synaptic Transmission|Biochemistry of Synaptic Transmission|Learning and Memory I|Learning and Memory IIElectrical and Chemical Synaptic Transmission|Mechanisms of Transmitter Release at Synapses|Indirect Mechanisms of Synaptic Transmission|Biochemistry of Synaptic Transmission|Learning and Memory I|Learning and Memory II
From Genes to Structure to Behavior|Nervous System Development I|Nervous System Development II|Axon Guidance I|Synapse Formation|Fine-Tuning Synaptic ConnectionsFrom Genes to Structure to Behavior|Nervous System Development I|Nervous System Development II|Axon Guidance I|Synapse Formation|Fine-Tuning Synaptic Connections
Vision I|Vision II|Hearing|Olfaction and Other Sensory Systems|Pain and Thermoreception|Higher Order Cognitive FunctionVision I|Vision II|Hearing|Olfaction and Other Sensory Systems|Pain and Thermoreception|Higher Order Cognitive Function
{table}{table}
h3 Ubiquitination: The Proteasome and Human Diseaseh3 Ubiquitination: The Proteasome and Human Disease
(http://ocw.mit.edu/OcwWeb/Biology/7-340Fall-2004/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Biology/7-340Fall-2004/CourseHome/index.htm)
__Course Description__:__Course Description__:
This seminar provides a deeper understanding of the post-translational mechanisms evolved by eukaryotic cells to target proteins for degradation. Students learn how proteins are recognized and degraded by specific machinery (the proteasome) through their previous tagging with another small protein, ubiquitin. Additional topics include principles of ubiquitin-proteasome function, its control of the most important cellular pathways, and the implication of this system in different human diseases. Finally, speculation on the novel techniques that arose from an increased knowledge of the ubiquitin-proteosome system and current applications in the design of new pharmacological agents to battle disease is also covered.This seminar provides a deeper understanding of the post-translational mechanisms evolved by eukaryotic cells to target proteins for degradation. Students learn how proteins are recognized and degraded by specific machinery (the proteasome) through their previous tagging with another small protein, ubiquitin. Additional topics include principles of ubiquitin-proteasome function, its control of the most important cellular pathways, and the implication of this system in different human diseases. Finally, speculation on the novel techniques that arose from an increased knowledge of the ubiquitin-proteosome system and current applications in the design of new pharmacological agents to battle disease is also covered.
__Lecture Notes__:__Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Biology/7-340Fall-2004/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Biology/7-340Fall-2004/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Introduction|Discovery of the Ubiquitin Conjugation System|Protein Degradation in Trafficking Membranes I: Endoplasmic Reticulum Associated Degradation (ERAD) Pathway|Protein Degradation in Trafficking Membranes II: Endocytosis and lysosomal Degradation|Role of Ubiquitination in Transcriptional Regulation|Role of Ubiquitination in Cell Cycle Control and Programmed Cell DeathIntroduction|Discovery of the Ubiquitin Conjugation System|Protein Degradation in Trafficking Membranes I: Endoplasmic Reticulum Associated Degradation (ERAD) Pathway|Protein Degradation in Trafficking Membranes II: Endocytosis and lysosomal Degradation|Role of Ubiquitination in Transcriptional Regulation|Role of Ubiquitination in Cell Cycle Control and Programmed Cell Death
Ubiquitin-like Proteins|Functions of the Ubiquitin-Proteasome System in the Immune System|Ubiquitin and Cancer|Ubiquitin and Neurodegenerative Diseases: Alzheimer's and Parkinson's Diseases|More Diseases Involving Ubiquitin: Huntington's and Von Hippel-Lindau Disease|Too Much Degradation Can Be as Bad as Not Enough: Cystic Fibrosis and Liddle's SyndromeUbiquitin-like Proteins|Functions of the Ubiquitin-Proteasome System in the Immune System|Ubiquitin and Cancer|Ubiquitin and Neurodegenerative Diseases: Alzheimer's and Parkinson's Diseases|More Diseases Involving Ubiquitin: Huntington's and Von Hippel-Lindau Disease|Too Much Degradation Can Be as Bad as Not Enough: Cystic Fibrosis and Liddle's Syndrome
Potential Therapeutic Strategies in Ubiquitin-Related Diseases|||||Potential Therapeutic Strategies in Ubiquitin-Related Diseases|||||
{table}{table}
h3 Under the Radar Screen: How Bugs Trick Our Immune Defensesh3 Under the Radar Screen: How Bugs Trick Our Immune Defenses
(http://ocw.mit.edu/OcwWeb/Biology/7-340Spring-2007/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Biology/7-340Spring-2007/CourseHome/index.htm)
__Course Description__:__Course Description__:
In this course, we will explore the specific ways by which microbes defeat our immune system and the molecular mechanisms that are under attack (phagocytosis, the ubiquitin/proteasome pathway, MHC I/II antigen presentation). Through our discussion and dissection of the primary research literature, we will explore aspects of host-pathogen interactions. We will particularly emphasize the experimental techniques used in the field and how to read and understand research data. Technological advances in the fight against microbes will also be discussed, with specific examples.In this course, we will explore the specific ways by which microbes defeat our immune system and the molecular mechanisms that are under attack (phagocytosis, the ubiquitin/proteasome pathway, MHC I/II antigen presentation). Through our discussion and dissection of the primary research literature, we will explore aspects of host-pathogen interactions. We will particularly emphasize the experimental techniques used in the field and how to read and understand research data. Technological advances in the fight against microbes will also be discussed, with specific examples.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Biology/7-340Spring-2007/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Biology/7-340Spring-2007/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Phagocytosis|Toll-like receptors (TLRs)|The proteasome and ubiquitin|Major histocompatibility (MHC) class I antigen presentation|Major histocompatiblity (MHC) class II antigen presentation|CytokinesPhagocytosis|Toll-like receptors (TLRs)|The proteasome and ubiquitin|Major histocompatibility (MHC) class I antigen presentation|Major histocompatiblity (MHC) class II antigen presentation|Cytokines
Programmed cell death|Molecular mimicry|Antimicrobial peptides: Innate immunity effectors|||Programmed cell death|Molecular mimicry|Antimicrobial peptides: Innate immunity effectors|||
{table}{table}
h3 The Radical Consequences of Respiration: Reactive Oxygen Species in Aging and Diseaseh3 The Radical Consequences of Respiration: Reactive Oxygen Species in Aging and Disease
(http://ocw.mit.edu/OcwWeb/Biology/7-343Fall-2007/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Biology/7-343Fall-2007/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course will start with a survey of basic oxygen radical biochemistry followed by a discussion of the mechanisms of action of cellular as well as dietary antioxidants. After considering the normal physiological roles of oxidants, we will examine the effects of elevated ROS and a failure of cellular redox capacity on the rate of organismal and cellular aging as well as on the onset and progression of several major diseases that are often age-related. Topics will include ROS-induced effects on stem cell regeneration, insulin resistance, heart disease, neurodegenerative disorders, and cancer. The role of antioxidants in potential therapeutic strategies for modulating ROS levels will also be discussed.This course will start with a survey of basic oxygen radical biochemistry followed by a discussion of the mechanisms of action of cellular as well as dietary antioxidants. After considering the normal physiological roles of oxidants, we will examine the effects of elevated ROS and a failure of cellular redox capacity on the rate of organismal and cellular aging as well as on the onset and progression of several major diseases that are often age-related. Topics will include ROS-induced effects on stem cell regeneration, insulin resistance, heart disease, neurodegenerative disorders, and cancer. The role of antioxidants in potential therapeutic strategies for modulating ROS levels will also be discussed.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Biology/7-343Fall-2007/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Biology/7-343Fall-2007/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Introduction and background|The high price of energy: Mitrochondrial production of ROS|Radical messengers: ROS as facilitators of cellular signaling|Hired assassins: ROS in anti-pathogen defense|Antioxidants: fighting the good fightThe free radical theory: ROS and agingIntroduction and background|The high price of energy: Mitrochondrial production of ROS|Radical messengers: ROS as facilitators of cellular signaling|Hired assassins: ROS in anti-pathogen defense|Antioxidants: fighting the good fightThe free radical theory: ROS and aging
The root of the problem: oxidative damage in stem cell renewal|Balancing act: ROS effects on insulin resistance and diabetes|Breaking hearts: ROS in ischemic reperfusion injury|Brain drain: oxidative stress in neurodegenerative diseases|Foot-soldiers of renegade cells: ROS in cancer and oncogenic transformation|Fighting fire with fire: more ROS or less ROS as therapeutic strategies?The root of the problem: oxidative damage in stem cell renewal|Balancing act: ROS effects on insulin resistance and diabetes|Breaking hearts: ROS in ischemic reperfusion injury|Brain drain: oxidative stress in neurodegenerative diseases|Foot-soldiers of renegade cells: ROS in cancer and oncogenic transformation|Fighting fire with fire: more ROS or less ROS as therapeutic strategies?
{table}{table}
h3 Protein Folding Problemh3 Protein Folding Problem
(http://ocw.mit.edu/OcwWeb/Biology/7-88JFall-2007/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Biology/7-88JFall-2007/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects.This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Biology/7-88JFall-2007/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Biology/7-88JFall-2007/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Introduction to the problem|Side-chain review + Sulfur redox chemistry|The Anfinsen experiments|Globular protein structure + Protein interiors|Using the Protein database (PDB)|Helix-helix packing in globular proteinsIntroduction to the problem|Side-chain review + Sulfur redox chemistry|The Anfinsen experiments|Globular protein structure + Protein interiors|Using the Protein database (PDB)|Helix-helix packing in globular proteins
Beta-sheets + Beta-sheet packing|Experimental techniques: circular dichroism|Thermal denaturation + Coiled coils + Refolding of tropomyosin|Fluorescence spectroscopy|S-peptide helical folding|Detecting partially folded intermediatesBeta-sheets + Beta-sheet packing|Experimental techniques: circular dichroism|Thermal denaturation + Coiled coils + Refolding of tropomyosin|Fluorescence spectroscopy|S-peptide helical folding|Detecting partially folded intermediates
Prolyl isomerization|Cytochrome c refolding pathway|2-D NMR techniques|Collagen structure and folding in vivo|Procollagen folding in vitro|Protein calorimetry: BPTIProlyl isomerization|Cytochrome c refolding pathway|2-D NMR techniques|Collagen structure and folding in vivo|Procollagen folding in vitro|Protein calorimetry: BPTI
Protein misfolding and aggregation|Ribosome channel + Nascent chains + Trigger factor|Scaffolding proteins in viral shell assembly|Amyloid fiber formation in neuro degenerative disease|Chaperonin assisted foldingProtein misfolding and aggregation|Ribosome channel + Nascent chains + Trigger factor|Scaffolding proteins in viral shell assembly|Amyloid fiber formation in neuro degenerative disease|Chaperonin assisted folding
Eukariotic chaperonins|Paper topic discussion and choices|Membrane protein (rhodopsin) folding and assembly|Prion diseases|Etiology of some human protein deposition diseases|Eukariotic chaperonins|Paper topic discussion and choices|Membrane protein (rhodopsin) folding and assembly|Prion diseases|Etiology of some human protein deposition diseases|
{table}{table}
h2 Brain and Cognitive Sciencesh2 Brain and Cognitive Sciences
h3 Neuroscience and Behaviorh3 Neuroscience and Behavior
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-01Fall-2003/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-01Fall-2003/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course covers the relation of structure and function at various levels of neuronal integration. Topics include functional neuroanatomy and neurophysiology, sensory and motor systems, centrally programmed behavior, sensory systems, sleep and dreaming, motivation and reward, emotional displays of various types, "higher functions" and the neocortex, and neural processes in learning and memory. This course covers the relation of structure and function at various levels of neuronal integration. Topics include functional neuroanatomy and neurophysiology, sensory and motor systems, centrally programmed behavior, sensory systems, sleep and dreaming, motivation and reward, emotional displays of various types, "higher functions" and the neocortex, and neural processes in learning and memory.
__Audio Lectures__:__Audio Lectures__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-01Fall-2003/AudioLectures/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-01Fall-2003/AudioLectures/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Introduction to Brain-behavior Studies|History and Goals, II|History and Goals, III|History and Goals, IV|Cellular Mechanisms|Neuronal Conduction and TransmissionIntroduction to Brain-behavior Studies|History and Goals, II|History and Goals, III|History and Goals, IV|Cellular Mechanisms|Neuronal Conduction and Transmission
Synapses + Neuroanatomical Techniques|Introduction to CNS and its Evolution|Evolution (cont.) + Reflex and Cerebellar Channels|Brain Subdivisions + Channels of Conduction|Transection Effects + Neocortex|Spinal Cord + Autonomic NSSynapses + Neuroanatomical Techniques|Introduction to CNS and its Evolution|Evolution (cont.) + Reflex and Cerebellar Channels|Brain Subdivisions + Channels of Conduction|Transection Effects + Neocortex|Spinal Cord + Autonomic NS
Hindbrain and Midbrain|Midbrain and Forebrain|Development of CNS, Introduction|Cell migration + Axon Growth Stages|Influences on Axon Growth|Axonal Sprouting and RegenerationHindbrain and Midbrain|Midbrain and Forebrain|Development of CNS, Introduction|Cell migration + Axon Growth Stages|Influences on Axon Growth|Axonal Sprouting and Regeneration
Motor System, 1|Motor System, 2|Motor System, 3|Motor 4: Rythmic Outputs|Rhythms of Activity + Sleep and Waking|Sleep and Waking (cont.)Motor System, 1|Motor System, 2|Motor System, 3|Motor 4: Rythmic Outputs|Rhythms of Activity + Sleep and Waking|Sleep and Waking (cont.)
Habituation, Novelty Responses|Visual System 1: Anatomy, Ablations|Visual System 2: Physiology (orig: Ablation Effects)|Visual System 3: Ablation Studies|Visual System 4: Ablations (cont.) (Orig: Electrophysiology)|Visual System ConclusionHabituation, Novelty Responses|Visual System 1: Anatomy, Ablations|Visual System 2: Physiology (orig: Ablation Effects)|Visual System 3: Ablation Studies|Visual System 4: Ablations (cont.) (Orig: Electrophysiology)|Visual System Conclusion
Auditory System|Pain and Central Gray Area|Hypothalamus and Feeding|Drive, Reward + Agonistic Behavior|Higher Functions + Human Nature|Human Nature and NeuroscienceAuditory System|Pain and Central Gray Area|Hypothalamus and Feeding|Drive, Reward + Agonistic Behavior|Higher Functions + Human Nature|Human Nature and Neuroscience
{table}{table}
h3 Neural Basis of Learning and Memoryh3 Neural Basis of Learning and Memory
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-03Fall-2007/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-03Fall-2007/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course highlights the interplay between cellular and molecular storage mechanisms and the cognitive neuroscience of memory, with an emphasis on human and animal models of hippocampal mechanisms and function. This course highlights the interplay between cellular and molecular storage mechanisms and the cognitive neuroscience of memory, with an emphasis on human and animal models of hippocampal mechanisms and function.
__Selected Lectures Notes__:__Selected Lectures Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-03Fall-2007/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-03Fall-2007/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Lecture 1: Brief History of Work in the Area of Learning and Memory|Lecture 2: Introduction; Cells and Synapses|Lecture 3: Neuroimaging Techniques|Lecture 4: Skill Memory|Lecture 6: Sensory, Short-Term, and Working Memory|Lecture 21: Observational Learning; Mirror NeuronsLecture 1: Brief History of Work in the Area of Learning and Memory|Lecture 2: Introduction; Cells and Synapses|Lecture 3: Neuroimaging Techniques|Lecture 4: Skill Memory|Lecture 6: Sensory, Short-Term, and Working Memory|Lecture 21: Observational Learning; Mirror Neurons
Lecture 23: Emotional Learning and Memory|||||Lecture 23: Emotional Learning and Memory|||||
{table}{table}
h3 Neural Basis of Vision and Auditionh3 Neural Basis of Vision and Audition
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-04Fall-2006/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-04Fall-2006/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course examines the neural bases of visual and auditory processing for perception and sensorimotor control, focusing on physiological and anatomical studies of the mammalian nervous system as well as behavioral studies of animals and humans. Visual pattern, color and depth perception, auditory responses and speech coding, and spatial localization are studied.This course examines the neural bases of visual and auditory processing for perception and sensorimotor control, focusing on physiological and anatomical studies of the mammalian nervous system as well as behavioral studies of animals and humans. Visual pattern, color and depth perception, auditory responses and speech coding, and spatial localization are studied.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-04Fall-2006/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-04Fall-2006/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
The layout of the visual system, the retina, and the lateral geniculate nucleus|The visual cortex|The ON and OFF channels|The midget and parasol channels|Adaptation and color|Depth perceptionThe layout of the visual system, the retina, and the lateral geniculate nucleus|The visual cortex|The ON and OFF channels|The midget and parasol channels|Adaptation and color|Depth perception
Form perception|Illusions and visual prosthetics|The neural control of visually guided eye movements, subcortical control|The neural control of visually guided eye movements, cortical control|Motion perception and pursuit eye movements|Hair cells: Transduction, electrophysiology and "Cochlear Amplifier"Form perception|Illusions and visual prosthetics|The neural control of visually guided eye movements, subcortical control|The neural control of visually guided eye movements, cortical control|Motion perception and pursuit eye movements|Hair cells: Transduction, electrophysiology and "Cochlear Amplifier"
Auditory nerve; psychophysics of frequency resolution|Hearing loss and cochlear implants|Cochlear nucleus: Tonotopy, unit types and cell types|Brainstem reflexes: OC efferents and middle ear muscles|Sound localization I: Psychophysics and neural circuits|Sound localization II: Superior olivary complex and inferior colliculusAuditory nerve; psychophysics of frequency resolution|Hearing loss and cochlear implants|Cochlear nucleus: Tonotopy, unit types and cell types|Brainstem reflexes: OC efferents and middle ear muscles|Sound localization I: Psychophysics and neural circuits|Sound localization II: Superior olivary complex and inferior colliculus
Auditory cortex I: General physiology and role in sound localization|Auditory cortex II: Language; Bats and echolocation|Eaton-Peabody lab tour at Massachusetts Eye and Ear Infirmary|Comparison of vision and audition, vision review||Auditory cortex I: General physiology and role in sound localization|Auditory cortex II: Language; Bats and echolocation|Eaton-Peabody lab tour at Massachusetts Eye and Ear Infirmary|Comparison of vision and audition, vision review||
{table}{table}
h3 Brain Mechanisms for Hearing and Speechh3 Brain Mechanisms for Hearing and Speech
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-722JFall-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-722JFall-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
An advanced course covering anatomical, physiological, behavioral, and computational studies of the central nervous system relevant to speech and hearing. Students learn primarily by discussions of scientific papers on topics of current interest. Recent topics include cell types and neural circuits in the auditory brainstem, organization and processing in the auditory cortex, auditory reflexes and descending systems, functional imaging of the human auditory system, quantitative methods for relating neural responses to behavior, speech motor control, cortical representation of language, and auditory learning in songbirds.An advanced course covering anatomical, physiological, behavioral, and computational studies of the central nervous system relevant to speech and hearing. Students learn primarily by discussions of scientific papers on topics of current interest. Recent topics include cell types and neural circuits in the auditory brainstem, organization and processing in the auditory cortex, auditory reflexes and descending systems, functional imaging of the human auditory system, quantitative methods for relating neural responses to behavior, speech motor control, cortical representation of language, and auditory learning in songbirds.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-722JFall-2005/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-722JFall-2005/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Dorsal Cochlear Nucleus|Descending Systems|Cell Types and Circuits|Quantitative Methods|Thalamus and Cortex|NeuroimagingDorsal Cochlear Nucleus|Descending Systems|Cell Types and Circuits|Quantitative Methods|Thalamus and Cortex|Neuroimaging
Speech Motor Control|Motor Control|Cortical Language Processing|||Speech Motor Control|Motor Control|Cortical Language Processing|||
{table}{table}
h3 Statistical Methods in Brain and Cognitive Scienceh3 Statistical Methods in Brain and Cognitive Science
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-07Spring-2004/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-07Spring-2004/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course emphasizes statistics as a powerful tool for studying complex issues in behavioral and biological sciences, and explores the limitations of statistics as a method of inquiry. The course covers descriptive statistics, probability and random variables, inferential statistics, and basic issues in experimental design. Techniques introduced include confidence intervals, t-tests, F-tests, regression, and analysis of variance. Assignments include a project in data analysis.This course emphasizes statistics as a powerful tool for studying complex issues in behavioral and biological sciences, and explores the limitations of statistics as a method of inquiry. The course covers descriptive statistics, probability and random variables, inferential statistics, and basic issues in experimental design. Techniques introduced include confidence intervals, t-tests, F-tests, regression, and analysis of variance. Assignments include a project in data analysis.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-07Spring-2004/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-07Spring-2004/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Introduction to Statistics|Describing Data + Graphs, Central Tendency, and Spread|Probability, I|Probability, I (cont.) + Probability, II|Random Variables|Sampling TheoryIntroduction to Statistics|Describing Data + Graphs, Central Tendency, and Spread|Probability, I|Probability, I (cont.) + Probability, II|Random Variables|Sampling Theory
Confidence Intervals|Single-sample Hypothesis Testing, I|Single-sample Hypothesis Testing, II|Two-sample Hypothesis Testing, I|Two Sample t-Test|Two-sample Hypothesis Testing, IIConfidence Intervals|Single-sample Hypothesis Testing, I|Single-sample Hypothesis Testing, II|Two-sample Hypothesis Testing, I|Two Sample t-Test|Two-sample Hypothesis Testing, II
Experimental Design, I|Experimental Design, II|Experimental Design, II (cont.) + Regression and Correlation, I|Regression and Correlation, II|Regression and Correlation, III|Chi-square TestsExperimental Design, I|Experimental Design, II|Experimental Design, II (cont.) + Regression and Correlation, I|Regression and Correlation, II|Regression and Correlation, III|Chi-square Tests
One-way ANOVA, I|One-way ANOVA, II|Two-way ANOVA, I|Two-way ANOVA, II||One-way ANOVA, I|One-way ANOVA, II|Two-way ANOVA, I|Two-way ANOVA, II||
{table}{table}
h3 Human Memory and Learningh3 Human Memory and Learning
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-081Human-Memory-and-LearningFall2002/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-081Human-Memory-and-LearningFall2002/CourseHome/index.htm)
__Course Description__:__Course Description__:
Surveys the literature on the cognitive and neural organization of human memory and learning. Includes consideration of working memory and executive control, episodic and semantic memory, and implicit forms of memory. Emphasizes integration of cognitive theory with recent insights from functional neuroimaging (e.g., fMRI and PET).Surveys the literature on the cognitive and neural organization of human memory and learning. Includes consideration of working memory and executive control, episodic and semantic memory, and implicit forms of memory. Emphasizes integration of cognitive theory with recent insights from functional neuroimaging (e.g., fMRI and PET).
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-081Human-Memory-and-LearningFall2002/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-081Human-Memory-and-LearningFall2002/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Lecture 1: What is Memory?|Lecture 3: Neuroimaging and Cognitive Control|Lecture 5: Episodic and PrimarycMemory|Lecture 9: Nondeclarative Memory||Lecture 1: What is Memory?|Lecture 3: Neuroimaging and Cognitive Control|Lecture 5: Episodic and PrimarycMemory|Lecture 9: Nondeclarative Memory||
{table}{table}
h3 Brain Structure and its Originsh3 Brain Structure and its Origins
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-14Spring-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-14Spring-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course covers major CNS structures with emphasis on systems being used as models for experimental studies of development and plasticity. Topics include basic patterns of connections in CNS, embryogenesis, PNS anatomy and development, process outgrowth and synaptogenesis, growth factors and cell survival, spinal and hindbrain anatomy, and development of regional specificity with an introduction to comparative anatomy and CNS evolution. A review of lab techniques (anatomy, tissue culture) is also covered as well as the trigeminal system, retinotectal system development, plasticity, regeneration, neocortex anatomy and development, the olfactory system, corpus striatum, brain transplants, the limbic system and hippocampal anatomy and plasticity.This course covers major CNS structures with emphasis on systems being used as models for experimental studies of development and plasticity. Topics include basic patterns of connections in CNS, embryogenesis, PNS anatomy and development, process outgrowth and synaptogenesis, growth factors and cell survival, spinal and hindbrain anatomy, and development of regional specificity with an introduction to comparative anatomy and CNS evolution. A review of lab techniques (anatomy, tissue culture) is also covered as well as the trigeminal system, retinotectal system development, plasticity, regeneration, neocortex anatomy and development, the olfactory system, corpus striatum, brain transplants, the limbic system and hippocampal anatomy and plasticity.
__Audio Lectures__:__Audio Lectures__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-14Spring-2005/AudioLectures/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-14Spring-2005/AudioLectures/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Introduction: Brain Orientation, Primitive Cellular Activities|Introduction: Methods; Primitive Cellular Activities|Steps to the CNS of Chordates|Steps to the CNS of Chordates (cont.)|Specializations in CNS Evolution|Specializations in CNS Evolution (cont.)Introduction: Brain Orientation, Primitive Cellular Activities|Introduction: Methods; Primitive Cellular Activities|Steps to the CNS of Chordates|Steps to the CNS of Chordates (cont.)|Specializations in CNS Evolution|Specializations in CNS Evolution (cont.)
Spinal Cord Development and Anatomy|Spinal Cord Development and Anatomy (cont.)|Differentiation of the Brain Vesicles|Differentiation of the Brain Vesicles (cont.)|Differentiation of the Brain Vesicles (cont.)|Differentiation of the Brain Vesicles (cont.)Spinal Cord Development and Anatomy|Spinal Cord Development and Anatomy (cont.)|Differentiation of the Brain Vesicles|Differentiation of the Brain Vesicles (cont.)|Differentiation of the Brain Vesicles (cont.)|Differentiation of the Brain Vesicles (cont.)
Axon Growth|Axon Growth (cont.)|Motor Systems|Motor Systems (cont.)|Taste and Olfactory Systems|Taste and Olfactory Systems (cont.)Axon Growth|Axon Growth (cont.)|Motor Systems|Motor Systems (cont.)|Taste and Olfactory Systems|Taste and Olfactory Systems (cont.)
Visual Systems|Visual Systems (cont.)|Visual Systems (cont.)|Auditory Systems|Auditory Systems (cont.)|Forebrain IntroductionVisual Systems|Visual Systems (cont.)|Visual Systems (cont.)|Auditory Systems|Auditory Systems (cont.)|Forebrain Introduction
Hypothalamus; Limbic System|Hypothalamus; Limbic System (cont.)|Hypothalamus; Limbic System (cont.)|Hypothalamus; Limbic System (cont.)|Hypothalamus; Limbic System (cont.)|Corpus StriatumHypothalamus; Limbic System|Hypothalamus; Limbic System (cont.)|Hypothalamus; Limbic System (cont.)|Hypothalamus; Limbic System (cont.)|Hypothalamus; Limbic System (cont.)|Corpus Striatum
Corpus Striatum (cont.)|Neocortex|Neocortex (cont.)|Neocortex (cont.)|Neocortex (cont.)|Plastic Systems: Cerebellum, Striatum, CortexCorpus Striatum (cont.)|Neocortex|Neocortex (cont.)|Neocortex (cont.)|Neocortex (cont.)|Plastic Systems: Cerebellum, Striatum, Cortex
{table}{table}
h3 Animal Behaviorh3 Animal Behavior
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-20Fall-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-20Fall-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
Most of the major categories of adaptive behavior can be seen in all animals. This course begins with the evolution of behavior, the driver of nervous system evolution, reviewed using concepts developed in ethology, sociobiology, other comparative studies, and in studies of brain evolution. The roles of various types of plasticity are considered, as well as foraging and feeding, defensive and aggressive behavior, courtship and reproduction, migration and navigation, social activities and communication, with contributions of inherited patterns and cognitive abilities. Both field and laboratory based studies are reviewed; and finally, human behavior is considered within the context of primate studies.Most of the major categories of adaptive behavior can be seen in all animals. This course begins with the evolution of behavior, the driver of nervous system evolution, reviewed using concepts developed in ethology, sociobiology, other comparative studies, and in studies of brain evolution. The roles of various types of plasticity are considered, as well as foraging and feeding, defensive and aggressive behavior, courtship and reproduction, migration and navigation, social activities and communication, with contributions of inherited patterns and cognitive abilities. Both field and laboratory based studies are reviewed; and finally, human behavior is considered within the context of primate studies.
__Audio Lectures__:__Audio Lectures__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-20Fall-2005/AudioLectures/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-20Fall-2005/AudioLectures/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Animals in Human History + Amateur and Professional Studies|Introduction to Ethology + Tinbergen's Four Questions + Field Studies of Birds|Lorenz' Jackdaws|Ethology of Geese + Fixed Action Patterns and the Central Nervous System|Input and Output Sides of Innate Behavior + MotivationAnimals in Human History + Amateur and Professional Studies|Introduction to Ethology + Tinbergen's Four Questions + Field Studies of Birds|Lorenz' Jackdaws|Ethology of Geese + Fixed Action Patterns and the Central Nervous System|Input and Output Sides of Innate Behavior + Motivation
Motivation (cont.)|Lorenz on Fixed Action Patterns|Lorenz on Innate Releasing Mechanisms|Models, Hierarchies and Chains of Action Patterns|Spatial Orientation + Multiple Motivations|Evolution of Behavior, Genes, LearningMotivation (cont.)|Lorenz on Fixed Action Patterns|Lorenz on Innate Releasing Mechanisms|Models, Hierarchies and Chains of Action Patterns|Spatial Orientation + Multiple Motivations|Evolution of Behavior, Genes, Learning
Navigation, Migration, Communication|Communication (cont.)|Foraging|Anti-predator Behavior|Anti-predator Behavior (cont.)|Mating and Reproduction, IntroductionNavigation, Migration, Communication|Communication (cont.)|Foraging|Anti-predator Behavior|Anti-predator Behavior (cont.)|Mating and Reproduction, Introduction
Sociobiology Introduction|Sociobiology Subject Matter|Genes and Behaviors|Sociobiology and Science|Discoveries of Sociobiology|Cultural Determinism and SociobiologySociobiology Introduction|Sociobiology Subject Matter|Genes and Behaviors|Sociobiology and Science|Discoveries of Sociobiology|Cultural Determinism and Sociobiology
Sociobiology and Culture|Practical Issues in Study of Adaptation|The Triumph of Sociobiology|||Sociobiology and Culture|Practical Issues in Study of Adaptation|The Triumph of Sociobiology|||
{table}{table}
h3 Neural Coding and Perception of Soundh3 Neural Coding and Perception of Sound
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-723Spring-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-723Spring-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course focuses on neural structures and mechanisms mediating the detection, localization and recognition of sounds. Discussions cover how acoustic signals are coded by auditory neurons, the impact of these codes on behavioral performance, and the circuitry and cellular mechanisms underlying signal transformations. Topics include temporal coding, neural maps and feature detectors, learning and plasticity, and feedback control. General principles are conveyed by theme discussions of auditory masking, sound localization, musical pitch, speech coding, and cochlear implants.This course focuses on neural structures and mechanisms mediating the detection, localization and recognition of sounds. Discussions cover how acoustic signals are coded by auditory neurons, the impact of these codes on behavioral performance, and the circuitry and cellular mechanisms underlying signal transformations. Topics include temporal coding, neural maps and feature detectors, learning and plasticity, and feedback control. General principles are conveyed by theme discussions of auditory masking, sound localization, musical pitch, speech coding, and cochlear implants.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-723Spring-2005/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-723Spring-2005/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Hearing and the Auditory System: An Overview|How the Ear Works (Functional Cochlear Mechanics)|Stimulus Coding in the Auditory Nerve|Masking and Frequency Selectivity|Masking and Nonlinearity|Masking and Nonlinearity (cont.)Hearing and the Auditory System: An Overview|How the Ear Works (Functional Cochlear Mechanics)|Stimulus Coding in the Auditory Nerve|Masking and Frequency Selectivity|Masking and Nonlinearity|Masking and Nonlinearity (cont.)
Cochlear Implants|Intensity Perception and Cochlear Hearing Loss|Channels, Synapses and Neurotransmitters|Cellular Mechanisms in the Cochlear Nucleus|Cellular Mechanisms in the Cochlear Nucleus|Cellular Mechanisms in the Cochlear NucleusCochlear Implants|Intensity Perception and Cochlear Hearing Loss|Channels, Synapses and Neurotransmitters|Cellular Mechanisms in the Cochlear Nucleus|Cellular Mechanisms in the Cochlear Nucleus|Cellular Mechanisms in the Cochlear Nucleus
Binaural Hearing|Binaural Interactions in the Auditory Brainstem|Binaural Interactions|Binaural Interactions|Pitch of Pure and Complex Tones|Neural Processing of PitchBinaural Hearing|Binaural Interactions in the Auditory Brainstem|Binaural Interactions|Binaural Interactions|Pitch of Pure and Complex Tones|Neural Processing of Pitch
Pitch and Temporal Coding|Pitch and Temporal Coding (cont.)|Auditory Cortex: Cortical organization|The Human Auditory System|Neural Maps and Plasticity|Neural Maps and Plasticity Pitch and Temporal Coding|Pitch and Temporal Coding (cont.)|Auditory Cortex: Cortical organization|The Human Auditory System|Neural Maps and Plasticity|Neural Maps and Plasticity
Auditory Scene Analysis (ASA) and Object Formation|Scene Analysis||||Auditory Scene Analysis (ASA) and Object Formation|Scene Analysis||||
{table}{table}
h3 Introduction to Computational Neuroscienceh3 Introduction to Computational Neuroscience
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-29JSpring-2004/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-29JSpring-2004/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course gives a mathematical introduction to neural coding and dynamics. Topics include convolution, correlation, linear systems, game theory, signal detection theory, probability theory, information theory, and reinforcement learning. Applications to neural coding, focusing on the visual system are covered, as well as Hodgkin-Huxley and other related models of neural excitability, stochastic models of ion channels, cable theory, and models of synaptic transmission.This course gives a mathematical introduction to neural coding and dynamics. Topics include convolution, correlation, linear systems, game theory, signal detection theory, probability theory, information theory, and reinforcement learning. Applications to neural coding, focusing on the visual system are covered, as well as Hodgkin-Huxley and other related models of neural excitability, stochastic models of ion channels, cable theory, and models of synaptic transmission.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-29JSpring-2004/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-29JSpring-2004/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Examples of Neural Coding, Simple Linear Regression|Convolution and Correlation 1 + Firing Rate|Simple Statistics and Linear Regression|Convolution and Correlation 2 + Spike-triggered Average + Wiener-Hopf Equations and White Noise Analysis|Operant Matching 1|Examples of Neural Coding, Simple Linear Regression|Convolution and Correlation 1 + Firing Rate|Simple Statistics and Linear Regression|Convolution and Correlation 2 + Spike-triggered Average + Wiener-Hopf Equations and White Noise Analysis|Operant Matching 1|
{table}{table}
h3 Neural Plasticity in Learning and Developmenth3 Neural Plasticity in Learning and Development
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-301JNeural-Plasticity-in-Learning-and-DevelopmentSpring2002/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-301JNeural-Plasticity-in-Learning-and-DevelopmentSpring2002/CourseHome/index.htm)
__Course Description__:__Course Description__:
Roles of neural plasticity in learning and memory and in development of invertebrates and mammals. An in-depth critical analysis of current literature of molecular, cellular, genetic, electrophysiological, and behavioral studies. Discussion of original papers supplemented by introductory lectures.Roles of neural plasticity in learning and memory and in development of invertebrates and mammals. An in-depth critical analysis of current literature of molecular, cellular, genetic, electrophysiological, and behavioral studies. Discussion of original papers supplemented by introductory lectures.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-301JNeural-Plasticity-in-Learning-and-DevelopmentSpring2002/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-301JNeural-Plasticity-in-Learning-and-DevelopmentSpring2002/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Lecture 1: Introduction|Lecture 2: Behavior and Plasticity|Lecture 3: Synaptic Transmission|Lecture 4: Potentiation of Synaptic Transmission|Lecture 5: Expression of Plasticity|Lecture 1: Introduction|Lecture 2: Behavior and Plasticity|Lecture 3: Synaptic Transmission|Lecture 4: Potentiation of Synaptic Transmission|Lecture 5: Expression of Plasticity|
{table}{table}
h3 Parkinson's Disease Workshoph3 Parkinson's Disease Workshop
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-458Summer-2006/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-458Summer-2006/CourseHome/index.htm)
__Course Description__:__Course Description__:
Parkinson's disease (PD) is a chronic, progressive, degenerative disease of the brain that produces movement disorders and deficits in executive functions, working memory, visuospatial functions, and internal control of attention. It is named after James Parkinson (1755-1824), the English neurologist who described the first case.Parkinson's disease (PD) is a chronic, progressive, degenerative disease of the brain that produces movement disorders and deficits in executive functions, working memory, visuospatial functions, and internal control of attention. It is named after James Parkinson (1755-1824), the English neurologist who described the first case.
This six-week summer workshop explored different aspects of PD, including clinical characteristics, structural neuroimaging, neuropathology, genetics, and cognitive function (mental status, cognitive control processes, working memory, and long-term declarative memory). The workshop did not take up the topics of motor control, nondeclarative memory, or treatment. This six-week summer workshop explored different aspects of PD, including clinical characteristics, structural neuroimaging, neuropathology, genetics, and cognitive function (mental status, cognitive control processes, working memory, and long-term declarative memory). The workshop did not take up the topics of motor control, nondeclarative memory, or treatment.
__Lecture Notes__:__Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-458Summer-2006/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-458Summer-2006/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Cognition in Parkinson's Disease|Neuropathology and Structural Neuroimaging in Parkinson's Disease|Genetics of Parkinson's Disease|Cognitive Control Processes and Working Memory in Parkinson's Disease|A Systems Neuroscience Approach to Memory|Long-term Declarative Memory in Parkinson DiseaseCognition in Parkinson's Disease|Neuropathology and Structural Neuroimaging in Parkinson's Disease|Genetics of Parkinson's Disease|Cognitive Control Processes and Working Memory in Parkinson's Disease|A Systems Neuroscience Approach to Memory|Long-term Declarative Memory in Parkinson Disease
{table}{table}
h3 Scene Understanding Symposiumh3 Scene Understanding Symposium
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-459Spring-2006/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-459Spring-2006/CourseHome/index.htm)
__Course Description__:__Course Description__:
What are the circuits, mechanisms and representations that permit the recognition of a visual scene from just one glance? In this one-day seminar on Scene Understanding, speakers from a variety of disciplines - neurophysiology, cognitive neuroscience, visual cognition, computational neuroscience and computer vision - will address a range of topics related to scene recognition, including natural image categorization, contextual effects on object recognition, and the role of attention in scene understanding and visual art. The goal is to encourage exchanges between researchers of all fields of brain sciences in the burgeoning field of scene understanding.What are the circuits, mechanisms and representations that permit the recognition of a visual scene from just one glance? In this one-day seminar on Scene Understanding, speakers from a variety of disciplines - neurophysiology, cognitive neuroscience, visual cognition, computational neuroscience and computer vision - will address a range of topics related to scene recognition, including natural image categorization, contextual effects on object recognition, and the role of attention in scene understanding and visual art. The goal is to encourage exchanges between researchers of all fields of brain sciences in the burgeoning field of scene understanding.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-459Spring-2006/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-459Spring-2006/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
From Zero to Gist in 200 msec: The Time Course of Scene Recognition|Feedforward Theories of Visual Cortex Predict Human Performance in Rapid Image Categorization|Latency, Duration and Codes for Objects in Inferior Temporal Cortex|From Feedforward Vision to Natural Vision: The Impact of Free Viewing, Task, and Clutter on Monkey Inferior Temporal Object Representations|Perception of Objects in Natural Scenes and the Role of Attention|Natural Scene Categorization: From Humans to ComputersFrom Zero to Gist in 200 msec: The Time Course of Scene Recognition|Feedforward Theories of Visual Cortex Predict Human Performance in Rapid Image Categorization|Latency, Duration and Codes for Objects in Inferior Temporal Cortex|From Feedforward Vision to Natural Vision: The Impact of Free Viewing, Task, and Clutter on Monkey Inferior Temporal Object Representations|Perception of Objects in Natural Scenes and the Role of Attention|Natural Scene Categorization: From Humans to Computers
Using the Forest to See the Trees: A Computational Model Relating Features, Objects and Scenes|Scene Perception after Those First Few Hundred Milliseconds||||Using the Forest to See the Trees: A Computational Model Relating Features, Objects and Scenes|Scene Perception after Those First Few Hundred Milliseconds||||
{table}{table}
h3 Statistical Learning Theory and Applicationsh3 Statistical Learning Theory and Applications
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-520Statistical-Learning-Theory-and-ApplicationsSpring2003/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-520Statistical-Learning-Theory-and-ApplicationsSpring2003/CourseHome/index.htm)
__Course Description__:__Course Description__:
Focuses on the problem of supervised learning from the perspective of modern statistical learning theory starting with the theory of multivariate function approximation from sparse data. Develops basic tools such as Regularization including Support Vector Machines for regression and classification. Derives generalization bounds using both stability and VC theory. Discusses topics such as boosting and feature selection. Examines applications in several areas: computer vision, computer graphics, text classification and bioinformatics.Focuses on the problem of supervised learning from the perspective of modern statistical learning theory starting with the theory of multivariate function approximation from sparse data. Develops basic tools such as Regularization including Support Vector Machines for regression and classification. Derives generalization bounds using both stability and VC theory. Discusses topics such as boosting and feature selection. Examines applications in several areas: computer vision, computer graphics, text classification and bioinformatics.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-520Statistical-Learning-Theory-and-ApplicationsSpring2003/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-520Statistical-Learning-Theory-and-ApplicationsSpring2003/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
The Learning Problem in Perspective|Regularization and Reproducing Kernel Hilbert Spaces|Regression and Least-Squares Classification|Support Vector Machines for Classification|Generalization Bounds, Introduction to Stability|Stability of Tikhonov RegularizationThe Learning Problem in Perspective|Regularization and Reproducing Kernel Hilbert Spaces|Regression and Least-Squares Classification|Support Vector Machines for Classification|Generalization Bounds, Introduction to Stability|Stability of Tikhonov Regularization
Consistency and Uniform Convergence Over Function Classes|Necessary and Sufficient Conditions for Uniform Convergence|Bagging and Boosting|Computer Vision, Object Detection|Approximation Theory|RKHS, Mercer Thm, Unbounded Domains, Frames and WaveletsConsistency and Uniform Convergence Over Function Classes|Necessary and Sufficient Conditions for Uniform Convergence|Bagging and Boosting|Computer Vision, Object Detection|Approximation Theory|RKHS, Mercer Thm, Unbounded Domains, Frames and Wavelets
Bioinformatics|Text|Regularization Networks|Morphable Models for Video|Leave-one-out Approximations|Bayesian InterpretationsBioinformatics|Text|Regularization Networks|Morphable Models for Video|Leave-one-out Approximations|Bayesian Interpretations
Multiclass Classification|Math Camp 1: Functional Analysis|Math Camp 2: Lagrange Multipliers/Convex Optimization|SVM Rules of Thumb||Multiclass Classification|Math Camp 1: Functional Analysis|Math Camp 2: Lagrange Multipliers/Convex Optimization|SVM Rules of Thumb||
{table}{table}
h3 Language Processingh3 Language Processing
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-591JFall-2004/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-591JFall-2004/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course is a seminar in real-time language comprehension. It considers models of sentence and discourse comprehension from the linguistic, psychology, and artificial intelligence literature, including symbolic and connectionist models. Topics include ambiguity resolution and linguistic complexity; the use of lexical, syntactic, semantic, pragmatic, contextual and prosodic information in language comprehension; the relationship between the computational resources available in working memory and the language processing mechanism; and the psychological reality of linguistic representations.This course is a seminar in real-time language comprehension. It considers models of sentence and discourse comprehension from the linguistic, psychology, and artificial intelligence literature, including symbolic and connectionist models. Topics include ambiguity resolution and linguistic complexity; the use of lexical, syntactic, semantic, pragmatic, contextual and prosodic information in language comprehension; the relationship between the computational resources available in working memory and the language processing mechanism; and the psychological reality of linguistic representations.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-591JFall-2004/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-591JFall-2004/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Course Overview + Modularity in Sentence Comprehension|Resources and Sentence Complexity + The Complexity of Unambiguous Sentences + The Dependency Locality Theory|Working Memory and Sentence Comprehension|Resources and Ambiguity Resolution + The Serial / Parallel Question|Experience / Frequency and Ambiguity Resolution|Symbolic Computational Approaches to Language Parsing + Parsing Strategies + Shift-reduce ParsingCourse Overview + Modularity in Sentence Comprehension|Resources and Sentence Complexity + The Complexity of Unambiguous Sentences + The Dependency Locality Theory|Working Memory and Sentence Comprehension|Resources and Ambiguity Resolution + The Serial / Parallel Question|Experience / Frequency and Ambiguity Resolution|Symbolic Computational Approaches to Language Parsing + Parsing Strategies + Shift-reduce Parsing
Referential and Contextual Issues in Sentence Comprehension|Event-related Potentials (ERPs) and Other Brain-imaging Methods Investigating Sentence Comprehension||||Referential and Contextual Issues in Sentence Comprehension|Event-related Potentials (ERPs) and Other Brain-imaging Methods Investigating Sentence Comprehension||||
{table}{table}
h3 Psycholinguisticsh3 Psycholinguistics
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-59JSpring-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-59JSpring-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course covers central topics in language processing, including: the structure of language; sentence, discourse, and morphological processing; storage and access of words in the mental dictionary; speech processing; the relationship between the computational resources available in working memory and the language processing mechanism; and ambiguity resolution. The course also considers computational modeling, including connectionist models; the relationship between language and thought; and issues in language acquisition including critical period phenomena, the acquisition of speech, and the acquisition of words. Experimental methodologies such as self-paced reading, eye-tracking, cross-modal priming, and neural imaging methods are also examined.This course covers central topics in language processing, including: the structure of language; sentence, discourse, and morphological processing; storage and access of words in the mental dictionary; speech processing; the relationship between the computational resources available in working memory and the language processing mechanism; and ambiguity resolution. The course also considers computational modeling, including connectionist models; the relationship between language and thought; and issues in language acquisition including critical period phenomena, the acquisition of speech, and the acquisition of words. Experimental methodologies such as self-paced reading, eye-tracking, cross-modal priming, and neural imaging methods are also examined.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-59JSpring-2005/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-59JSpring-2005/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Syntax I|Syntax II|Syntax III|Sentence Parsing + Sentence Comprehension I|Sentence Comprehension II|Sentence Comprehension IIISyntax I|Syntax II|Syntax III|Sentence Parsing + Sentence Comprehension I|Sentence Comprehension II|Sentence Comprehension III
Sentence Processing IV|Semantic and Pragmatic Processing|Sentence and Discourse Comprehension|Discourse Comprehension|Neural Imaging and Language Processing|SpeechSentence Processing IV|Semantic and Pragmatic Processing|Sentence and Discourse Comprehension|Discourse Comprehension|Neural Imaging and Language Processing|Speech
Speech (cont.)|Speech Perception and Production|Words: Visual Word Recognition|Language Acquisition||Speech (cont.)|Speech Perception and Production|Words: Visual Word Recognition|Language Acquisition||
{table}{table}
h3 Language Acquisition Ih3 Language Acquisition I
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-601JLanguage-Acquisition-ISpring2002/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-601JLanguage-Acquisition-ISpring2002/CourseHome/index.htm)
__Course Description__:__Course Description__:
Lectures, reading, and discussion of current theory and data concerning the psychology and biology of language acquisition. Emphasizes learning of syntax and morphology, together with some discussion of phonology, and especially research relating grammatical theory and learnability theory to empirical studies of children.Lectures, reading, and discussion of current theory and data concerning the psychology and biology of language acquisition. Emphasizes learning of syntax and morphology, together with some discussion of phonology, and especially research relating grammatical theory and learnability theory to empirical studies of children.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-601JLanguage-Acquisition-ISpring2002/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-601JLanguage-Acquisition-ISpring2002/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Development of the Morphosyntax of Verbal Inflections|The OI Stage in English||||Development of the Morphosyntax of Verbal Inflections|The OI Stage in English||||
{table}{table}
h3 Natural Language and the Computer Representation of Knowledgeh3 Natural Language and the Computer Representation of Knowledge
(http://ocw.mit.edu/OcwWeb/Electrical-Engineering-and-Computer-Science/6-863JSpring2003/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Electrical-Engineering-and-Computer-Science/6-863JSpring2003/CourseHome/index.htm)
__Course Description__:__Course Description__:
Natural Language and the Computer Representation of Knowledge is a laboratory-oriented course on the theory and practice of building computer systems for human language processing, with an emphasis on the linguistic, cognitive, and engineering foundations for understanding their design.Natural Language and the Computer Representation of Knowledge is a laboratory-oriented course on the theory and practice of building computer systems for human language processing, with an emphasis on the linguistic, cognitive, and engineering foundations for understanding their design.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Electrical-Engineering-and-Computer-Science/6-863JSpring2003/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Electrical-Engineering-and-Computer-Science/6-863JSpring2003/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Introduction, Organization, Laboratories, Course Overview: Introduction to NLP, Main Issues, fsa's|Linguistics:Phonology and Morphology I, 2-level morphology, Kimmo|Linguistics:Phonology and Morphology II|HMM Tagging, Statistical Transformation RuleBased Tagging, Precision, Recall, Accuracy|Part of Speech Tagging:The Brill Tagger|Introduction to Parsing, Linguistics:Syntax & ParsingIntroduction, Organization, Laboratories, Course Overview: Introduction to NLP, Main Issues, fsa's|Linguistics:Phonology and Morphology I, 2-level morphology, Kimmo|Linguistics:Phonology and Morphology II|HMM Tagging, Statistical Transformation RuleBased Tagging, Precision, Recall, Accuracy|Part of Speech Tagging:The Brill Tagger|Introduction to Parsing, Linguistics:Syntax & Parsing
Shift-Reduce Parsers in Detail, Earley's Algorithm and Chart Parsing|Context-Free Parsing and Beyond: Efficiency Issues, Feature-Based Parsing, NL System Design|Shift-Reduce Parsers in Detail, Earley's Algorithm and Chart Parsing|Parsing with an Integrated Lexicon - The Question of Syntactic Features|Semantic Interpretation I: Compositionality|Semantic Interpretation II: Compositionality and QuantifiersShift-Reduce Parsers in Detail, Earley's Algorithm and Chart Parsing|Context-Free Parsing and Beyond: Efficiency Issues, Feature-Based Parsing, NL System Design|Shift-Reduce Parsers in Detail, Earley's Algorithm and Chart Parsing|Parsing with an Integrated Lexicon - The Question of Syntactic Features|Semantic Interpretation I: Compositionality|Semantic Interpretation II: Compositionality and Quantifiers
Semantics III: Lexical Semantics|Semantics IV: Lexical Semantics|Semantics V: Constraint-Based Systems|Machine Translation I|Machine Translation III|Machine Translation IVSemantics III: Lexical Semantics|Semantics IV: Lexical Semantics|Semantics V: Constraint-Based Systems|Machine Translation I|Machine Translation III|Machine Translation IV
Language Learning I|Language Learning II||||Language Learning I|Language Learning II||||
{table}{table}
h3 Laboratory in Cognitive Scienceh3 Laboratory in Cognitive Science
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-63Fall-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-63Fall-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
Laboratory in Cognitive Science teaches principles of experimental methods in human perception and cognition, including design and statistical analysis. The course combines lectures and hands-on experimental exercises and requires an independent experimental project. Some experience in programming is desirable.Laboratory in Cognitive Science teaches principles of experimental methods in human perception and cognition, including design and statistical analysis. The course combines lectures and hands-on experimental exercises and requires an independent experimental project. Some experience in programming is desirable.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-63Fall-2005/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-63Fall-2005/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Variables and Controls - Signal Detection Theory|Single Factor Design and Statistics (T-test)|Factorial Design and External Validity|Factorial Design and Statistical Analysis (ANOVA)|Experimental Paradigms in Cognitive Science|Cognitive Neuroscience MethodsVariables and Controls - Signal Detection Theory|Single Factor Design and Statistics (T-test)|Factorial Design and External Validity|Factorial Design and Statistical Analysis (ANOVA)|Experimental Paradigms in Cognitive Science|Cognitive Neuroscience Methods
Single Participant Experiments, Quasi-Experiments|Correlational Studies and Non Experimental Research|Writing a Paper|Experiments in Other Sciences|Ethics in Research|Single Participant Experiments, Quasi-Experiments|Correlational Studies and Non Experimental Research|Writing a Paper|Experiments in Other Sciences|Ethics in Research|
{table}{table}
h3 Introduction to Neural Networksh3 Introduction to Neural Networks
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-641JSpring-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-641JSpring-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course explores the organization of synaptic connectivity as the basis of neural computation and learning. Perceptrons and dynamical theories of recurrent networks including amplifiers, attractors, and hybrid computation are covered. Additional topics include backpropagation and Hebbian learning, as well as models of perception, motor control, memory, and neural development.This course explores the organization of synaptic connectivity as the basis of neural computation and learning. Perceptrons and dynamical theories of recurrent networks including amplifiers, attractors, and hybrid computation are covered. Additional topics include backpropagation and Hebbian learning, as well as models of perception, motor control, memory, and neural development.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-641JSpring-2005/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-641JSpring-2005/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
From Spikes to Rates|Lateral Inhibition and Feature Selectivity|Hamiltonian Dynamics|Antisymmetric Networks|Excitatory-Inhibitory Networks|VQ + PCAFrom Spikes to Rates|Lateral Inhibition and Feature Selectivity|Hamiltonian Dynamics|Antisymmetric Networks|Excitatory-Inhibitory Networks|VQ + PCA
Delta Rule|Conditioning + Backpropagation|More Backpropagation|||Delta Rule|Conditioning + Backpropagation|More Backpropagation|||
{table}{table}
h3 Computational Cognitive Scienceh3 Computational Cognitive Science
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-66JFall-2004/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-66JFall-2004/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course is an introduction to computational theories of human cognition. Drawing on formal models from classic and contemporary artificial intelligence, students will explore fundamental issues in human knowledge representation, inductive learning and reasoning. What are the forms that our knowledge of the world takes? What are the inductive principles that allow us to acquire new knowledge from the interaction of prior knowledge with observed data? What kinds of data must be available to human learners, and what kinds of innate knowledge (if any) must they have?This course is an introduction to computational theories of human cognition. Drawing on formal models from classic and contemporary artificial intelligence, students will explore fundamental issues in human knowledge representation, inductive learning and reasoning. What are the forms that our knowledge of the world takes? What are the inductive principles that allow us to acquire new knowledge from the interaction of prior knowledge with observed data? What kinds of data must be available to human learners, and what kinds of innate knowledge (if any) must they have?
__Lecture Notes__:__Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-66JFall-2004/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-66JFall-2004/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Foundations of Inductive Learning|Knowledge Representation: Spaces, Trees, Features|Knowledge Representation: Language and Logic 1|Knowledge Representation: Language and Logic 2|Knowledge Representation: Great Debates 1|Knowledge Representation: Great Debates 2Foundations of Inductive Learning|Knowledge Representation: Spaces, Trees, Features|Knowledge Representation: Language and Logic 1|Knowledge Representation: Language and Logic 2|Knowledge Representation: Great Debates 1|Knowledge Representation: Great Debates 2
Basic Bayesian Inference|Graphical Models and Bayes Nets|Simple Bayesian Learning 1|Simple Bayesian Learning 2|Probabilistic Models for Concept Learning and Categorization 1|Probabilistic Models for Concept Learning and Categorization 2Basic Bayesian Inference|Graphical Models and Bayes Nets|Simple Bayesian Learning 1|Simple Bayesian Learning 2|Probabilistic Models for Concept Learning and Categorization 1|Probabilistic Models for Concept Learning and Categorization 2
Unsupervised and Semi-supervised Learning|Non-parametric Classification: Exemplar Models and Neural Networks 1|Non-parametric Classification: Exemplar Models and Neural Networks 2|Controlling Complexity and Occam's Razor 1|Controlling Complexity and Occam's Razor 2|Intuitive Biology and the Role of TheoriesUnsupervised and Semi-supervised Learning|Non-parametric Classification: Exemplar Models and Neural Networks 1|Non-parametric Classification: Exemplar Models and Neural Networks 2|Controlling Complexity and Occam's Razor 1|Controlling Complexity and Occam's Razor 2|Intuitive Biology and the Role of Theories
Learning Domain Structures 1|Learning Domain Structures 2|Causal Learning|Causal Theories 1|Causal Theories 2|Learning Domain Structures 1|Learning Domain Structures 2|Causal Learning|Causal Theories 1|Causal Theories 2|
{table}{table}
h3 Special Topics: Genetics, Neurobiology, and Pathophysiology of Psychiatric Disordersh3 Special Topics: Genetics, Neurobiology, and Pathophysiology of Psychiatric Disorders
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-914Fall-2008/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-914Fall-2008/CourseHome/index.htm)
__Course Description__:__Course Description__:
The key topics covered in this course are Bipolar Disorder, Psychosis, Schizophrenia, Genetics of Psychiatric Disorder, DISC1, Ca++ Signaling, Neurogenesis and Depression, Lithium and GSK3 Hypothesis, Behavioral Assays, CREB in Addiction and Depressive Behaviors, The GABA System-I, The GABA System-II, The Glutamate Hypothesis of Schizophrenia, The Dopamine Pathway and DARPP32.The key topics covered in this course are Bipolar Disorder, Psychosis, Schizophrenia, Genetics of Psychiatric Disorder, DISC1, Ca++ Signaling, Neurogenesis and Depression, Lithium and GSK3 Hypothesis, Behavioral Assays, CREB in Addiction and Depressive Behaviors, The GABA System-I, The GABA System-II, The Glutamate Hypothesis of Schizophrenia, The Dopamine Pathway and DARPP32.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-914Fall-2008/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-914Fall-2008/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
General introduction|DISC1|Literature discussion: neurogenesis and depression|Literature discussion: the dopamine pathway and DARPP32||General introduction|DISC1|Literature discussion: neurogenesis and depression|Literature discussion: the dopamine pathway and DARPP32||
{table}{table}
h3 Language and Mindh3 Language and Mind
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-98Language-and-MindJanuary-IAP-2003/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-98Language-and-MindJanuary-IAP-2003/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course will address some fundamental questions regarding human language: (1) how language is represented in our minds; (2) how language is acquired by children; (3) how language is processed by adults; (4) the relationship between language and thought; (5) exploring how language is represented and processed using brain imaging methods; and (6) computational modeling of human language acquisition and processing.This course will address some fundamental questions regarding human language: (1) how language is represented in our minds; (2) how language is acquired by children; (3) how language is processed by adults; (4) the relationship between language and thought; (5) exploring how language is represented and processed using brain imaging methods; and (6) computational modeling of human language acquisition and processing.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-98Language-and-MindJanuary-IAP-2003/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-98Language-and-MindJanuary-IAP-2003/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Why Study Language?|The Human Brain: Brain Areas|The Structure of Language|Relationship Between Language and Thought Beyond Cross-linguistic Differences||Why Study Language?|The Human Brain: Brain Areas|The Structure of Language|Relationship Between Language and Thought Beyond Cross-linguistic Differences||
{table}{table}
h3 Neuropharmacologyh3 Neuropharmacology
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-98January-IAP-2009/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-98January-IAP-2009/CourseHome/index.htm)
__Course Description__:__Course Description__:
The neuropharmacology course will discuss the drug-induced changes in functioning of the nervous system. The specific focus of this course will be to provide a description of the cellular and molecular actions of drugs on synaptic transmission. This course will also refer to specific diseases of the nervous system and their treatment in addition to giving an overview of the techniques used for the study of neuropharmacology.The neuropharmacology course will discuss the drug-induced changes in functioning of the nervous system. The specific focus of this course will be to provide a description of the cellular and molecular actions of drugs on synaptic transmission. This course will also refer to specific diseases of the nervous system and their treatment in addition to giving an overview of the techniques used for the study of neuropharmacology.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-98January-IAP-2009/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-98January-IAP-2009/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Basics of neuroscience|The neurotransmitter systems|Neuropsychiatric disorders: anxiety, mood disorders|Neuropsychiatric disorders: schizophrenia||Basics of neuroscience|The neurotransmitter systems|Neuropsychiatric disorders: anxiety, mood disorders|Neuropsychiatric disorders: schizophrenia||
{table}{table}
h2 Health Sciences and Technologyh2 Health Sciences and Technology
h3 Musculoskeletal Pathophysiologyh3 Musculoskeletal Pathophysiology
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-021January-IAP-2006/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-021January-IAP-2006/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course covers the growth, development and structure of normal bone and joints, the biomechanics of bone connective tissues, and their response to stress, calcium and phosphate homeostasis. Additional topics include regulation by parathyroid hormone and vitamin D, the pathogenesis of metabolic bone diseases and diseases of connective tissues, joints and muscle with consideration of possible mechanisms and underlying metabolic derangements.This course covers the growth, development and structure of normal bone and joints, the biomechanics of bone connective tissues, and their response to stress, calcium and phosphate homeostasis. Additional topics include regulation by parathyroid hormone and vitamin D, the pathogenesis of metabolic bone diseases and diseases of connective tissues, joints and muscle with consideration of possible mechanisms and underlying metabolic derangements.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-021January-IAP-2006/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-021January-IAP-2006/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Rheumatic Diseases (I) + Rheumatic Diseases (II)|Pathogenesis of Rheumatoid Arthritis + Rheumatic Diseases (III), Vasculitis|||||Rheumatic Diseases (I) + Rheumatic Diseases (II)|Pathogenesis of Rheumatoid Arthritis + Rheumatic Diseases (III), Vasculitis|||||
{table}{table}
h3 Principle and Practice of Human Pathologyh3 Principle and Practice of Human Pathology
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-035Spring2003/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-035Spring2003/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course provides a comprehensive overview of human pathology with emphasis on mechanisms of disease and diagnostic medicine. Topics include:This course provides a comprehensive overview of human pathology with emphasis on mechanisms of disease and diagnostic medicine. Topics include:
•Cellular Mechanisms of Disease•Cellular Mechanisms of Disease
•Molecular Pathology•Molecular Pathology
•Pathology of Major Organ Systems•Pathology of Major Organ Systems
•Review of Diagnostic Tools from Traditional Surgical Pathology to Diagnostic Spectroscopy•Review of Diagnostic Tools from Traditional Surgical Pathology to Diagnostic Spectroscopy
•Functional and Molecular Imaging•Functional and Molecular Imaging
•Molecular Diagnostics•Molecular Diagnostics
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-035Spring2003/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-035Spring2003/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Introduction to Human Pathology and Diagnostic Medicine|Epithelial Structure and Function|The Immune System|Cell Injury, Adaptation and Death|Acute and Chronic Inflammation|Tissue Repair, Fibrosis and HealingIntroduction to Human Pathology and Diagnostic Medicine|Epithelial Structure and Function|The Immune System|Cell Injury, Adaptation and Death|Acute and Chronic Inflammation|Tissue Repair, Fibrosis and Healing
Infectious Diseases: "The Biological Conflict of Interest"|Transplantation: "Friendly Organs in a Hostile Environment"|Are We What We Eat? "The Link Between Diet and Disease Development"|Ischemia and Infarction|Genetic Disorders|The LiverInfectious Diseases: "The Biological Conflict of Interest"|Transplantation: "Friendly Organs in a Hostile Environment"|Are We What We Eat? "The Link Between Diet and Disease Development"|Ischemia and Infarction|Genetic Disorders|The Liver
{table}{table}
h3 Human Reproductive Biologyh3 Human Reproductive Biology
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-071Fall-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-071Fall-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course is designed to give the student a clear understanding of the pathophysiology of the menstrual cycle, fertilization, implantation, ovum growth development, differentiation and associated abnormalities. Disorders of fetal development including the principles of teratology and the mechanism of normal and abnormal parturition will be covered as well as the pathophysiology of the breast and disorders of lactation. Fetal asphyxia and its consequences will be reviewed with emphasis on the technology currently available for its detection. In addition the conclusion of the reproductive cycle, menopause, and the use of hormonal replacement will be covered.This course is designed to give the student a clear understanding of the pathophysiology of the menstrual cycle, fertilization, implantation, ovum growth development, differentiation and associated abnormalities. Disorders of fetal development including the principles of teratology and the mechanism of normal and abnormal parturition will be covered as well as the pathophysiology of the breast and disorders of lactation. Fetal asphyxia and its consequences will be reviewed with emphasis on the technology currently available for its detection. In addition the conclusion of the reproductive cycle, menopause, and the use of hormonal replacement will be covered.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-071Fall-2005/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-071Fall-2005/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Male System Physiology|Male Fertility, Temperature and the Testes|Endometriosis|Clinical Pathological Conference: Female Reproductive System|Abnormalities of the Menstrual Cycle|Uterine Pathology: FibroidsMale System Physiology|Male Fertility, Temperature and the Testes|Endometriosis|Clinical Pathological Conference: Female Reproductive System|Abnormalities of the Menstrual Cycle|Uterine Pathology: Fibroids
Ovarian Pathology|Non-hormonal Contraception I + Non-hormonal Contraception II|Hormonal Contraception|Phytoestrogens|The Placenta|Placental PathologyOvarian Pathology|Non-hormonal Contraception I + Non-hormonal Contraception II|Hormonal Contraception|Phytoestrogens|The Placenta|Placental Pathology
Clinical Pathological Conference: Menstrual Cycle|Cervical Pathology and Cancer|Clinical Pathological Conference: Cervix|Sexual Differentiation I + Sexual Differentiation II|Assisted Reproductive Technology|Maternal Physiology I + Maternal Physiology IIClinical Pathological Conference: Menstrual Cycle|Cervical Pathology and Cancer|Clinical Pathological Conference: Cervix|Sexual Differentiation I + Sexual Differentiation II|Assisted Reproductive Technology|Maternal Physiology I + Maternal Physiology II
Hypertension in Pregnancy|Parturition|Polycystic Ovarian Syndrome (PCO)|Ovarian Failure|Toxoplasmosis|IsoimmunizationHypertension in Pregnancy|Parturition|Polycystic Ovarian Syndrome (PCO)|Ovarian Failure|Toxoplasmosis|Isoimmunization
Ultrasound Prenatal Diagnosis|Energy and Radiation Impact on Pregnancy|Prenatal Genetic Diagnosis|Fetal Surveillance|Pregnancy Termination Technology|Ultrasound Prenatal Diagnosis|Energy and Radiation Impact on Pregnancy|Prenatal Genetic Diagnosis|Fetal Surveillance|Pregnancy Termination Technology|
{table}{table}
h3 Gastroenterologyh3 Gastroenterology
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-121Fall-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-121Fall-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
The most recent knowledge of the anatomy, physiology, biochemistry, biophysics, and bioengineering of the gastrointestinal tract and the associated pancreatic, liver and biliary tract systems is presented and discussed. Gross and microscopic pathology and the clinical aspects of important gastroenterological diseases are then presented, with emphasis on integrating the molecular, cellular and pathophysiological aspects of the disease processes to their related symptoms and signs.The most recent knowledge of the anatomy, physiology, biochemistry, biophysics, and bioengineering of the gastrointestinal tract and the associated pancreatic, liver and biliary tract systems is presented and discussed. Gross and microscopic pathology and the clinical aspects of important gastroenterological diseases are then presented, with emphasis on integrating the molecular, cellular and pathophysiological aspects of the disease processes to their related symptoms and signs.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-121Fall-2005/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-121Fall-2005/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Overview of Embryology|Overview of Physiology|Gastroduodenal Pathophysiology and Disorders|Pathology of Esophagus and Stomach|Mucosal Immunology of the GI Tract|Lipid Digestion, Absorption and MalabsorptionOverview of Embryology|Overview of Physiology|Gastroduodenal Pathophysiology and Disorders|Pathology of Esophagus and Stomach|Mucosal Immunology of the GI Tract|Lipid Digestion, Absorption and Malabsorption
Pathology of the Intestines|Gastrointestinal Neoplasms|Physiological Chemistry of GI Lipids|Pathology of Pancreas and Biliary Tract|Biliary Secretion, Cholestasis and Gallstone Formation|Pathology of the LiverPathology of the Intestines|Gastrointestinal Neoplasms|Physiological Chemistry of GI Lipids|Pathology of Pancreas and Biliary Tract|Biliary Secretion, Cholestasis and Gallstone Formation|Pathology of the Liver
Jaundice and Disorders of Bilirubin Metabolism|Alcohol and Drug-Induced Liver Disease||||Jaundice and Disorders of Bilirubin Metabolism|Alcohol and Drug-Induced Liver Disease||||
{table}{table}
h3 Principles of Pharmacologyh3 Principles of Pharmacology
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-151Spring-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-151Spring-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
The object of the course is to teach students an approach to the study of pharmacologic agents. It is not intended to be a review of the pharmacopoeia. The focus is on the basic principles of biophysics, biochemistry and physiology, as related to the mechanisms of drug action, biodistribution and metabolism. Topics covered include: mechanisms of drug action, dose-response relations, pharmacokinetics, drug delivery systems, drug metabolism, toxicity of pharmacological agents, drug interaction and substance abuse. Selected agents and classes of agents are examined in detail.The object of the course is to teach students an approach to the study of pharmacologic agents. It is not intended to be a review of the pharmacopoeia. The focus is on the basic principles of biophysics, biochemistry and physiology, as related to the mechanisms of drug action, biodistribution and metabolism. Topics covered include: mechanisms of drug action, dose-response relations, pharmacokinetics, drug delivery systems, drug metabolism, toxicity of pharmacological agents, drug interaction and substance abuse. Selected agents and classes of agents are examined in detail.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-151Spring-2005/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-151Spring-2005/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Pharmacokinetics I|Pharmacokinetics II|Case: Anticholinesterase|Autonomic Pharmacology I and II|Antidysrhythmics|Antiinflammatory DrugsPharmacokinetics I|Pharmacokinetics II|Case: Anticholinesterase|Autonomic Pharmacology I and II|Antidysrhythmics|Antiinflammatory Drugs
Vasoactive Drugs I|Vasoactive Drugs II: Heart Failure|Lipid Lowering Drugs|Immunosuppression for Solid Organ Transplantation|Neuropharmacology I: Drugs for Movement Disorders|Nitric OxideVasoactive Drugs I|Vasoactive Drugs II: Heart Failure|Lipid Lowering Drugs|Immunosuppression for Solid Organ Transplantation|Neuropharmacology I: Drugs for Movement Disorders|Nitric Oxide
Neuropharmacology II: Anxiolytics and Antidepressants|Neuropharmacology III: Anticonvulsants|Antimicrobials I and II|Chemotherapy I and II|Opioids I and II|Neuropharmacology II: Anxiolytics and Antidepressants|Neuropharmacology III: Anticonvulsants|Antimicrobials I and II|Chemotherapy I and II|Opioids I and II|
{table}{table}
h3 Cellular and Molecular Immunologyh3 Cellular and Molecular Immunology
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-176Fall-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-176Fall-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course covers cells and tissues of the immune system, lymphocyte development, the structure and function of antigen receptors, the cell biology of antigen processing and presentation, including molecular structure and assembly of MHC molecules, the biology of cytokines, leukocyte-endothelial interactions, and the pathogenesis of immunologically mediated diseases.This course covers cells and tissues of the immune system, lymphocyte development, the structure and function of antigen receptors, the cell biology of antigen processing and presentation, including molecular structure and assembly of MHC molecules, the biology of cytokines, leukocyte-endothelial interactions, and the pathogenesis of immunologically mediated diseases.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-176Fall-2005/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-176Fall-2005/LectureNotes/index.htm)
20052005
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Cells of the Immune System|Lymphocyte Homing|Antibodies and Antigens|Antigen Receptors and the Generation of Diversity|B Lymphocyte Development and Activation|Antigen PresentationCells of the Immune System|Lymphocyte Homing|Antibodies and Antigens|Antigen Receptors and the Generation of Diversity|B Lymphocyte Development and Activation|Antigen Presentation
T Lymphocyte Development|Cell Mediated Immunity|Frontiers: Costimulation|Memory and Death|Tumor Immunology|Genetic Susceptibility to DiseaseT Lymphocyte Development|Cell Mediated Immunity|Frontiers: Costimulation|Memory and Death|Tumor Immunology|Genetic Susceptibility to Disease
{table}{table}
20022002
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Cells of Immune System and Innate Immunity|Antibodies|Antibody-dependent Protection Mechanisms|Antigen Receptors and Development of Diversity|T Lymphocyte Development|B Lymphocyte Dev and ActivationCells of Immune System and Innate Immunity|Antibodies|Antibody-dependent Protection Mechanisms|Antigen Receptors and Development of Diversity|T Lymphocyte Development|B Lymphocyte Dev and Activation
Cell-mediated Immunity|Lymphocyte Homing|MHC/Antigen Presentation|Lymphocyte Activation, Cytokines, Costim|Transplantation Immunology|Immunology of HIV DiseaseCell-mediated Immunity|Lymphocyte Homing|MHC/Antigen Presentation|Lymphocyte Activation, Cytokines, Costim|Transplantation Immunology|Immunology of HIV Disease
Costimulation|Memory and Death in Immune System|IgE System and Immediate Type Hypersens|Tumor Immunity|Immunodeficiency Syndromes|Costimulation|Memory and Death in Immune System|IgE System and Immediate Type Hypersens|Tumor Immunity|Immunodeficiency Syndromes|
{table}{table}
h3 Projects in Microscale Engineering for the Life Sciencesh3 Projects in Microscale Engineering for the Life Sciences
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-410JSpring-2007/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-410JSpring-2007/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course is a project-based introduction to manipulating and characterizing cells and biological molecules using microfabricated tools. It is designed for first year undergraduate students.This course is a project-based introduction to manipulating and characterizing cells and biological molecules using microfabricated tools. It is designed for first year undergraduate students.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-410JSpring-2007/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-410JSpring-2007/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Microfluidics|Microfabrication|Cells and membranes|Cells and membranes (cont.)|Models of diffusion and cell experiment|Laminar flowMicrofluidics|Microfabrication|Cells and membranes|Cells and membranes (cont.)|Models of diffusion and cell experiment|Laminar flow
Data analysis using MATLAB®|Research applications|Cell traps|||Data analysis using MATLAB®|Research applications|Cell traps|||
{table}{table}
h3 Statistical Physics in Biologyh3 Statistical Physics in Biology
(http://ocw.mit.edu/OcwWeb/Physics/8-592JSpring-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Physics/8-592JSpring-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
Statistical Physics in Biology is a survey of problems at the interface of statistical physics and modern biology. Topics include: bioinformatic methods for extracting information content of DNA; gene finding, sequence comparison, and phylogenetic trees; physical interactions responsible for structure of biopolymers; DNA double helix, secondary structure of RNA, and elements of protein folding; considerations of force, motion, and packaging; protein motors, membranes. We also look at collective behavior of biological elements, cellular networks, neural networks, and evolution. Statistical Physics in Biology is a survey of problems at the interface of statistical physics and modern biology. Topics include: bioinformatic methods for extracting information content of DNA; gene finding, sequence comparison, and phylogenetic trees; physical interactions responsible for structure of biopolymers; DNA double helix, secondary structure of RNA, and elements of protein folding; considerations of force, motion, and packaging; protein motors, membranes. We also look at collective behavior of biological elements, cellular networks, neural networks, and evolution.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Physics/8-592JSpring-2005/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Physics/8-592JSpring-2005/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Introduction to Course|Molecular Evolution|Mutations|Gene Annotation and Similarity Detection|Substitution Matrices|Dynamic Programming and Transfer MatricesIntroduction to Course|Molecular Evolution|Mutations|Gene Annotation and Similarity Detection|Substitution Matrices|Dynamic Programming and Transfer Matrices
Sequence Alignment and Statistical Physics|Biomolecular Forces and Energies|Electrostatics|Polymer Theory|Proteins|The Random Energy ModelSequence Alignment and Statistical Physics|Biomolecular Forces and Energies|Electrostatics|Polymer Theory|Proteins|The Random Energy Model
Fluctuating DNA|RNA|Protein-DNA Complexes|Microtubules and Filaments|Molecular Motors|MembranesFluctuating DNA|RNA|Protein-DNA Complexes|Microtubules and Filaments|Molecular Motors|Membranes
Cell Motility|Networks|Biological Patterns|||Cell Motility|Networks|Biological Patterns|||
{table}{table}
h3 Survival Skills for Researchers: The Responsible Conduct of Researchh3 Survival Skills for Researchers: The Responsible Conduct of Research
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-502Survival-Skills-for-Researchers--The-Responsible-Conduct-of-ResearchSpring2003/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-502Survival-Skills-for-Researchers--The-Responsible-Conduct-of-ResearchSpring2003/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course is designed to provide graduate students and postdoctoral associates with techniques that enhance both validity and responsible conduct in scientific practice. Lectures present practical steps for developing skills in scientific research and are combined with discussion of cases. The course covers study design, preparation of proposals and manuscripts, peer review, authorship, use of humans and non-human animals in research, allegations of misconduct, and intellectual property. Also discussed are mentoring relationships and career options. Aspects of responsible research conduct are integrated into lectures and case discussion as appropriate to the specific topic. This course is designed to provide graduate students and postdoctoral associates with techniques that enhance both validity and responsible conduct in scientific practice. Lectures present practical steps for developing skills in scientific research and are combined with discussion of cases. The course covers study design, preparation of proposals and manuscripts, peer review, authorship, use of humans and non-human animals in research, allegations of misconduct, and intellectual property. Also discussed are mentoring relationships and career options. Aspects of responsible research conduct are integrated into lectures and case discussion as appropriate to the specific topic.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-502Survival-Skills-for-Researchers-The-Responsible-Conduct-of-ResearchSpring2003/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-502Survival-Skills-for-Researchers-The-Responsible-Conduct-of-ResearchSpring2003/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Professional Ethics and Bias in Research Design; Lab Animals in Research|Study Design|Human Subjects in Research|Data Acquisition, Management, and Sharing|Credit and Responsibility in Science|Literature Review and Preparing Proposals and ManuscriptsProfessional Ethics and Bias in Research Design; Lab Animals in Research|Study Design|Human Subjects in Research|Data Acquisition, Management, and Sharing|Credit and Responsibility in Science|Literature Review and Preparing Proposals and Manuscripts
Peer Review|Allegations of Misconduct|Advisors and Mentors|Career Pathways||Peer Review|Allegations of Misconduct|Advisors and Mentors|Career Pathways||
{table}{table}
h3 Genomics and Computational Biologyh3 Genomics and Computational Biology
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-508Genomics-and-Computational-BiologyFall2002/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-508Genomics-and-Computational-BiologyFall2002/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course will assess the relationships among sequence, structure, and function in complex biological networks as well as progress in realistic modeling of quantitative, comprehensive, functional genomics analyses. Exercises will include algorithmic, statistical, database, and simulation approaches and practical applications to medicine, biotechnology, drug discovery, and genetic engineering. Future opportunities and current limitations will be critically addressed. This course will assess the relationships among sequence, structure, and function in complex biological networks as well as progress in realistic modeling of quantitative, comprehensive, functional genomics analyses. Exercises will include algorithmic, statistical, database, and simulation approaches and practical applications to medicine, biotechnology, drug discovery, and genetic engineering. Future opportunities and current limitations will be critically addressed.
__Lecture Notes (Audio available)__:__Lecture Notes (Audio available)__:
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-508Genomics-and-Computational-BiologyFall2002/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-508Genomics-and-Computational-BiologyFall2002/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Intro 1: Computational Side of Computational Biology. Statistics; Perl, Mathematica|Intro 2: Biological Side of Computational Biology. Comparative Genomics, Models & Applications|DNA 1: Genome Sequencing, Polymorphisms, Populations, Statistics, Pharmacogenomics; Databases|DNA 2: Dynamic Programming, Blast, Multi-alignment, HiddenMarkovModels|RNA 1: Microarrays, Library Sequencing and Quantitation Concepts|RNA 2: Clustering by Gene or Condition and Other Regulon Data Sources Nucleic Acid Motifs; The Nature of Biological "proofs"Intro 1: Computational Side of Computational Biology. Statistics; Perl, Mathematica|Intro 2: Biological Side of Computational Biology. Comparative Genomics, Models & Applications|DNA 1: Genome Sequencing, Polymorphisms, Populations, Statistics, Pharmacogenomics; Databases|DNA 2: Dynamic Programming, Blast, Multi-alignment, HiddenMarkovModels|RNA 1: Microarrays, Library Sequencing and Quantitation Concepts|RNA 2: Clustering by Gene or Condition and Other Regulon Data Sources Nucleic Acid Motifs; The Nature of Biological "proofs"
Protein 1: 3D Structural Genomics, Homology, Catalytic and Regulatory Dynamics, Function & Drug Design|Protein 2: Mass Spectrometry, Post-synthetic Modifications, Quantitation of Proteins, Metabolites, & Interactions|Networks 1: Systems Biology, Metabolic Kinetic & Flux Balance Optimization Methods|Networks 2: Molecular Computing, Self-assembly, Genetic Algorithms, Neural Networks|Networks 3: The Future of Computational Biology: Cellular, Developmental, Social, Ecological & Commercial Models|Protein 1: 3D Structural Genomics, Homology, Catalytic and Regulatory Dynamics, Function & Drug Design|Protein 2: Mass Spectrometry, Post-synthetic Modifications, Quantitation of Proteins, Metabolites, & Interactions|Networks 1: Systems Biology, Metabolic Kinetic & Flux Balance Optimization Methods|Networks 2: Molecular Computing, Self-assembly, Genetic Algorithms, Neural Networks|Networks 3: The Future of Computational Biology: Cellular, Developmental, Social, Ecological & Commercial Models|
{table}{table}
h3 Quantitative Genomicsh3 Quantitative Genomics
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-508Fall-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-508Fall-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course provides a foundation in the following four areas: evolutionary and population genetics; comparative genomics; structural genomics and proteomics; and functional genomics and regulation.This course provides a foundation in the following four areas: evolutionary and population genetics; comparative genomics; structural genomics and proteomics; and functional genomics and regulation.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-508Fall-2005/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-508Fall-2005/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
The Basic Forces of Evolution: Mutation, Recombination and Mating, Migration, Neutral Evolution and Drift, Effective Population Size|Selection, Fitness, Probability of Fixation, Coalescent Theory|Selection, Fitness, and Diffusion Models|Medical Lecture: Human Variations Genes, Genotypes and Generations|Overview of Protein Structures, Domain ArchitectureThe Basic Forces of Evolution: Mutation, Recombination and Mating, Migration, Neutral Evolution and Drift, Effective Population Size|Selection, Fitness, Probability of Fixation, Coalescent Theory|Selection, Fitness, and Diffusion Models|Medical Lecture: Human Variations Genes, Genotypes and Generations|Overview of Protein Structures, Domain Architecture
Structure-based Substitution Matrices|Gene Regulation and Function, Conservation, Detecting Regulatory Elements|RNA Expression: Clustering and Classification|RNA Expression: Classification, 2-way Clustering, Regulatory Modules||Structure-based Substitution Matrices|Gene Regulation and Function, Conservation, Detecting Regulatory Elements|RNA Expression: Clustering and Classification|RNA Expression: Classification, 2-way Clustering, Regulatory Modules||
{table}{table}
h3 Genomics and Computational Biologyh3 Genomics and Computational Biology
(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-508-genomics-and-computational-biology-fall-2002/)(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-508-genomics-and-computational-biology-fall-2002/)
__Course Description__:__Course Description__:
This course will assess the relationships among sequence, structure, and function in complex biological networks as well as progress in realistic modeling of quantitative, comprehensive, functional genomics analyses. Exercises will include algorithmic, statistical, database, and simulation approaches and practical applications to medicine, biotechnology, drug discovery, and genetic engineering. Future opportunities and current limitations will be critically addressed.This course will assess the relationships among sequence, structure, and function in complex biological networks as well as progress in realistic modeling of quantitative, comprehensive, functional genomics analyses. Exercises will include algorithmic, statistical, database, and simulation approaches and practical applications to medicine, biotechnology, drug discovery, and genetic engineering. Future opportunities and current limitations will be critically addressed.
__Lecture Notes (Audio Lectures also available)__:__Lecture Notes (Audio Lectures also available)__:
(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-508-genomics-and-computational-biology-fall-2002/lecture-notes/)(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-508-genomics-and-computational-biology-fall-2002/lecture-notes/)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Intro 1: Computational Side of Computational Biology. Statistics; Perl, Mathematica|Intro 2: Biological Side of Computational Biology. Comparative Genomics, Models & Applications|DNA 1: Genome Sequencing, Polymorphisms, Populations, Statistics, Pharmacogenomics; Databases|DNA 2: Dynamic Programming, Blast, Multi-alignment, HiddenMarkovModels|RNA 1: Microarrays, Library Sequencing and Quantitation Concepts|RNA 2: Clustering by Gene or Condition and Other Regulon Data Sources Nucleic Acid Motifs; The Nature of Biological "proofs"Intro 1: Computational Side of Computational Biology. Statistics; Perl, Mathematica|Intro 2: Biological Side of Computational Biology. Comparative Genomics, Models & Applications|DNA 1: Genome Sequencing, Polymorphisms, Populations, Statistics, Pharmacogenomics; Databases|DNA 2: Dynamic Programming, Blast, Multi-alignment, HiddenMarkovModels|RNA 1: Microarrays, Library Sequencing and Quantitation Concepts|RNA 2: Clustering by Gene or Condition and Other Regulon Data Sources Nucleic Acid Motifs; The Nature of Biological "proofs"
Protein 1: 3D Structural Genomics, Homology, Catalytic and Regulatory Dynamics, Function & Drug Design|Protein 2: Mass Spectrometry, Post-synthetic Modifications, Quantitation of Proteins, Metabolites, & Interactions|Networks 1: Systems Biology, Metabolic Kinetic & Flux Balance Optimization Methods|Networks 2: Molecular Computing, Self-assembly, Genetic Algorithms, Neural Networks|Networks 3: The Future of Computational Biology: Cellular, Developmental, Social, Ecological & Commercial Models|Protein 1: 3D Structural Genomics, Homology, Catalytic and Regulatory Dynamics, Function & Drug Design|Protein 2: Mass Spectrometry, Post-synthetic Modifications, Quantitation of Proteins, Metabolites, & Interactions|Networks 1: Systems Biology, Metabolic Kinetic & Flux Balance Optimization Methods|Networks 2: Molecular Computing, Self-assembly, Genetic Algorithms, Neural Networks|Networks 3: The Future of Computational Biology: Cellular, Developmental, Social, Ecological & Commercial Models|
{table}{table}
h3 Genomics, Computing, Economics, and Societyh3 Genomics, Computing, Economics, and Society
(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-510-genomics-computing-economics-and-society-fall-2005/)(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-510-genomics-computing-economics-and-society-fall-2005/)
__Course Description__:__Course Description__:
This course will focus on understanding aspects of modern technology displaying exponential growth curves and the impact on global quality of life through a weekly updated class project integrating knowledge and providing practical tools for political and business decision-making concerning new aspects of bioengineering, personalized medicine, genetically modified organisms, and stem cells. Interplays of economic, ethical, ecological, and biophysical modeling will be explored through multi-disciplinary teams of students, and individual brief reports.This course will focus on understanding aspects of modern technology displaying exponential growth curves and the impact on global quality of life through a weekly updated class project integrating knowledge and providing practical tools for political and business decision-making concerning new aspects of bioengineering, personalized medicine, genetically modified organisms, and stem cells. Interplays of economic, ethical, ecological, and biophysical modeling will be explored through multi-disciplinary teams of students, and individual brief reports.
__Lecture Notes__:__Lecture Notes__:
(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-510-genomics-computing-economics-and-society-fall-2005/lecture-notes/)(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-510-genomics-computing-economics-and-society-fall-2005/lecture-notes/)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Exercise - A Quantitative Definition of Life|New Energy Sources and Personalized Medicine|Biosphere Facts|Metabolic Networks and Learning Perl||Exercise - A Quantitative Definition of Life|New Energy Sources and Personalized Medicine|Biosphere Facts|Metabolic Networks and Learning Perl||
{table}{table}
h3 Genomic Medicineh3 Genomic Medicine
(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-512-genomic-medicine-spring-2004/)(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-512-genomic-medicine-spring-2004/)
__Course Description__:__Course Description__:
This course reviews the key genomic technologies and computational approaches that are driving advances in prognostics, diagnostics, and treatment. Throughout the semester, emphasis will return to issues surrounding the context of genomics in medicine including: what does a physician need to know? what sorts of questions will s/he likely encounter from patients? how should s/he respond? Lecturers will guide the student through real world patient-doctor interactions. Outcome considerations and socioeconomic implications of personalized medicine are also discussed. The first part of the course introduces key basic concepts of molecular biology, computational biology, and genomics. Continuing in the informatics applications portion of the course, lecturers begin each lecture block with a scenario, in order to set the stage and engage the student by showing: why is this important to know? how will the information presented be brought to bear on medical practice? The final section presents the ethical, legal, and social issues surrounding genomic medicine. A vision of how genomic medicine relates to preventative care and public health is presented in a discussion forum with the students where the following questions are explored: what is your level of preparedness now? what challenges must be met by the healthcare industry to get to where it needs to be?This course reviews the key genomic technologies and computational approaches that are driving advances in prognostics, diagnostics, and treatment. Throughout the semester, emphasis will return to issues surrounding the context of genomics in medicine including: what does a physician need to know? what sorts of questions will s/he likely encounter from patients? how should s/he respond? Lecturers will guide the student through real world patient-doctor interactions. Outcome considerations and socioeconomic implications of personalized medicine are also discussed. The first part of the course introduces key basic concepts of molecular biology, computational biology, and genomics. Continuing in the informatics applications portion of the course, lecturers begin each lecture block with a scenario, in order to set the stage and engage the student by showing: why is this important to know? how will the information presented be brought to bear on medical practice? The final section presents the ethical, legal, and social issues surrounding genomic medicine. A vision of how genomic medicine relates to preventative care and public health is presented in a discussion forum with the students where the following questions are explored: what is your level of preparedness now? what challenges must be met by the healthcare industry to get to where it needs to be?
__Audio Lectures (Selected Lecture Notes also available)__:__Audio Lectures (Selected Lecture Notes also available)__:
(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-512-genomic-medicine-spring-2004/lecture-notes/)(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-512-genomic-medicine-spring-2004/lecture-notes/)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Genomic Introduction|Introduction to Biology and Genomic Measurement|Measurement Techniques|Microarray - Massively Parrallel Measuremment|Limits of Technologies|Information Science at the Center of Genomic MedicineGenomic Introduction|Introduction to Biology and Genomic Measurement|Measurement Techniques|Microarray - Massively Parrallel Measuremment|Limits of Technologies|Information Science at the Center of Genomic Medicine
Informational Resources|Complex Traits: What to Believe|Machine-learning Approach|Association with Markers|The Importance of Data Representation|PharmacogenomicsInformational Resources|Complex Traits: What to Believe|Machine-learning Approach|Association with Markers|The Importance of Data Representation|Pharmacogenomics
Case Hx: Complex Traits|Individualized Pharmacology|Microarray Disease Classification|Microarray Disease Classification II|Direct Prediction of Outcome / Mortality|Case Hx: Cancer DiagnosticsCase Hx: Complex Traits|Individualized Pharmacology|Microarray Disease Classification|Microarray Disease Classification II|Direct Prediction of Outcome / Mortality|Case Hx: Cancer Diagnostics
Modelling and Reverse Engineering|Practical Genomic Medicine||||Modelling and Reverse Engineering|Practical Genomic Medicine||||
{table}{table}
h3 Biomaterials-Tissue Interactionsh3 Biomaterials-Tissue Interactions
(http://ocw.mit.edu/courses/biological-engineering/20-441-biomaterials-tissue-interactions-be-441-fall-2003/)(http://ocw.mit.edu/courses/biological-engineering/20-441-biomaterials-tissue-interactions-be-441-fall-2003/)
__Course Description__:__Course Description__:
This course is an introduction to principles of materials science and cell biology underlying the design of medical implants, artificial organs, and matrices for tissue engineering. Topics include methods for biomaterials surface characterization and analysis of protein adsorption on biomaterials. Molecular and cellular interactions with biomaterials are analyzed in terms of unit cell processes, such as matrix synthesis, degradation, and contraction. It also covers mechanisms underlying wound healing and tissue remodeling following implantation in various organs. Other areas include tissue and organ regeneration; design of implants and prostheses based on control of biomaterials-tissue interactions; comparative analysis of intact, biodegradable, and bioreplaceable implants by reference to case studies. Also addressed are criteria for restoration of physiological function for tissues and organs.This course is an introduction to principles of materials science and cell biology underlying the design of medical implants, artificial organs, and matrices for tissue engineering. Topics include methods for biomaterials surface characterization and analysis of protein adsorption on biomaterials. Molecular and cellular interactions with biomaterials are analyzed in terms of unit cell processes, such as matrix synthesis, degradation, and contraction. It also covers mechanisms underlying wound healing and tissue remodeling following implantation in various organs. Other areas include tissue and organ regeneration; design of implants and prostheses based on control of biomaterials-tissue interactions; comparative analysis of intact, biodegradable, and bioreplaceable implants by reference to case studies. Also addressed are criteria for restoration of physiological function for tissues and organs.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/courses/biological-engineering/20-441-biomaterials-tissue-interactions-be-441-fall-2003/lecture-notes/)(http://ocw.mit.edu/courses/biological-engineering/20-441-biomaterials-tissue-interactions-be-441-fall-2003/lecture-notes/)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Survey of Clinical Cases of Biomaterials-Tissue Interactions|Tissue Structures, Unit Cell Processes, and Integrins|Unit Cell Processes Comprising the Healing Response|Irreversible Healing Behavior of the Extracellular Matrix (ECM) of Organs|Biochemistry of the ECM|Scaffolds Based on ECM Analogs Used in Organ SynthesisSurvey of Clinical Cases of Biomaterials-Tissue Interactions|Tissue Structures, Unit Cell Processes, and Integrins|Unit Cell Processes Comprising the Healing Response|Irreversible Healing Behavior of the Extracellular Matrix (ECM) of Organs|Biochemistry of the ECM|Scaffolds Based on ECM Analogs Used in Organ Synthesis
Organ Replacement by Induced Regeneration and Tissue Engineering|Principles and Practice of Tissue Engineering|Characteristics of the Surfaces of Biomaterials|Linear vs. Cooperative Cell-Matrix Interactions|Cell-Matrix Interactions During Spontaneous Healing|Contraction-Blocking Theory of Regeneration in AdultsOrgan Replacement by Induced Regeneration and Tissue Engineering|Principles and Practice of Tissue Engineering|Characteristics of the Surfaces of Biomaterials|Linear vs. Cooperative Cell-Matrix Interactions|Cell-Matrix Interactions During Spontaneous Healing|Contraction-Blocking Theory of Regeneration in Adults
Joints and Dental Tissues: Prosthetic Replacement|Joints and Dental Tissues: Regeneration 1|Joints and Dental Tissues: Regeneration 2|Rules for Synthesis of Tissues and Organs|In Vivo Synthesis of Skin|In Vivo Synthesis of Peripheral NervesJoints and Dental Tissues: Prosthetic Replacement|Joints and Dental Tissues: Regeneration 1|Joints and Dental Tissues: Regeneration 2|Rules for Synthesis of Tissues and Organs|In Vivo Synthesis of Skin|In Vivo Synthesis of Peripheral Nerves
{table}{table}
h3 Cell-Matrix Mechanicsh3 Cell-Matrix Mechanics
(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-523j-cell-matrix-mechanics-spring-2004/)(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-523j-cell-matrix-mechanics-spring-2004/)
__Course Description__:__Course Description__:
Mechanical forces play a decisive role during development of tissues and organs, during remodeling following injury as well as in normal function. A stress field influences cell function primarily through deformation of the extracellular matrix to which cells are attached. Deformed cells express different biosynthetic activity relative to undeformed cells. The unit cell process paradigm combined with topics in connective tissue mechanics form the basis for discussions of several topics from cell biology, physiology, and medicine.Mechanical forces play a decisive role during development of tissues and organs, during remodeling following injury as well as in normal function. A stress field influences cell function primarily through deformation of the extracellular matrix to which cells are attached. Deformed cells express different biosynthetic activity relative to undeformed cells. The unit cell process paradigm combined with topics in connective tissue mechanics form the basis for discussions of several topics from cell biology, physiology, and medicine.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-523j-cell-matrix-mechanics-spring-2004/lecture-notes/)(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-523j-cell-matrix-mechanics-spring-2004/lecture-notes/)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Clinical Examples of the Roles of Mechanical Forces in Tissues and Organs: The Working Paradigms|Tissue Structures and Unit Cell Processes|Cell-Matrix Interactions: Extracellular Matrix Molecules, Adhesion Proteins and Integrins|Models for the Mechanical Behavior of Porous Scaffolds|Response of Cells to Substrate Strain|Measuring Cell Contraction + Cell Force MonitorClinical Examples of the Roles of Mechanical Forces in Tissues and Organs: The Working Paradigms|Tissue Structures and Unit Cell Processes|Cell-Matrix Interactions: Extracellular Matrix Molecules, Adhesion Proteins and Integrins|Models for the Mechanical Behavior of Porous Scaffolds|Response of Cells to Substrate Strain|Measuring Cell Contraction + Cell Force Monitor
Endogenous Mechanical Force Generation by Cells|Models for Cell Contraction In Vitro and In Vivo|Mechanical Coupling of Cells with Matrix|Cell-matrix Interactions During Wound Closure|Blockade of Contraction During Induced Organ Regeneration|Review of Principles of Linear Elastic MechanicsEndogenous Mechanical Force Generation by Cells|Models for Cell Contraction In Vitro and In Vivo|Mechanical Coupling of Cells with Matrix|Cell-matrix Interactions During Wound Closure|Blockade of Contraction During Induced Organ Regeneration|Review of Principles of Linear Elastic Mechanics
Nonlinear Elasticity: Tendon and Skin|Linear Viscoelastic Behavior|Mechanical Behavior of Ligament, Meniscus and Intervertebral Disc|Mechanical Behavior of Bone|Response of Bone to Mechanical Loading|Nonlinear Elasticity: Tendon and Skin|Linear Viscoelastic Behavior|Mechanical Behavior of Ligament, Meniscus and Intervertebral Disc|Mechanical Behavior of Bone|Response of Bone to Mechanical Loading|
{table}{table}
h3 Tumor Pathophysiology and Transport Phenomenah3 Tumor Pathophysiology and Transport Phenomena
(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-525j-tumor-pathophysiology-and-transport-phenomena-fall-2005/) (http://ocw.mit.edu/courses/health-sciences-and-technology/hst-525j-tumor-pathophysiology-and-transport-phenomena-fall-2005/)
__Course Description__:__Course Description__:
Tumor pathophysiology plays a central role in the growth, invasion, metastasis and treatment of solid tumors. This class applies principles of transport phenomena to develop a systems-level, quantitative understanding of angiogenesis, blood flow and microcirculation, metabolism and microenvironment, transport and binding of small and large molecules, movement of cancer and immune cells, metastatic process, and treatment response.Tumor pathophysiology plays a central role in the growth, invasion, metastasis and treatment of solid tumors. This class applies principles of transport phenomena to develop a systems-level, quantitative understanding of angiogenesis, blood flow and microcirculation, metabolism and microenvironment, transport and binding of small and large molecules, movement of cancer and immune cells, metastatic process, and treatment response.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-525j-tumor-pathophysiology-and-transport-phenomena-fall-2005/lecture-notes/)(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-525j-tumor-pathophysiology-and-transport-phenomena-fall-2005/lecture-notes/)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Delivery of Molecular Medicine to Tumors I: Vascular Transport and the Normalization Hypothesis|Delivery of Molecular Medicine to Tumors II: Interstitial and Lymphatic Transport|Role of Bone Marrow-Derived Cells in Cancer|||Delivery of Molecular Medicine to Tumors I: Vascular Transport and the Normalization Hypothesis|Delivery of Molecular Medicine to Tumors II: Interstitial and Lymphatic Transport|Role of Bone Marrow-Derived Cells in Cancer|||
{table}{table}
h3 Principles and Practice of Tissue Engineeringh3 Principles and Practice of Tissue Engineering
(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-535-principles-and-practice-of-tissue-engineering-fall-2004/)(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-535-principles-and-practice-of-tissue-engineering-fall-2004/)
__Course Description__:__Course Description__:
The principles and practice of tissue engineering (and regenerative medicine) are taught by faculty of the Harvard-MIT Division of Health Sciences and Technology (HST) and Tsinghua University, Beijing, China. The principles underlying strategies for employing selected cells, biomaterial scaffolds, soluble regulators or their genes, and mechanical loading and culture conditions, for the regeneration of tissues and organs in vitro and in vivo are addressed. Differentiated cell types and stem cells are compared and contrasted for this application, as are natural and synthetic scaffolds. Methodology for the preparation of cells and scaffolds in practice is described. The rationale for employing selected growth factors is covered and the techniques for incorporating their genes into the scaffolds are examined. Discussion also addresses the influence of environmental factors including mechanical loading and culture conditions (e.g., static versus dynamic). Methods for fabricating tissue-engineered products and devices for implantation are taught. Examples of tissue engineering-based procedures currently employed clinically are analyzed as case studies.The principles and practice of tissue engineering (and regenerative medicine) are taught by faculty of the Harvard-MIT Division of Health Sciences and Technology (HST) and Tsinghua University, Beijing, China. The principles underlying strategies for employing selected cells, biomaterial scaffolds, soluble regulators or their genes, and mechanical loading and culture conditions, for the regeneration of tissues and organs in vitro and in vivo are addressed. Differentiated cell types and stem cells are compared and contrasted for this application, as are natural and synthetic scaffolds. Methodology for the preparation of cells and scaffolds in practice is described. The rationale for employing selected growth factors is covered and the techniques for incorporating their genes into the scaffolds are examined. Discussion also addresses the influence of environmental factors including mechanical loading and culture conditions (e.g., static versus dynamic). Methods for fabricating tissue-engineered products and devices for implantation are taught. Examples of tissue engineering-based procedures currently employed clinically are analyzed as case studies.
(Archived webcast lecture videos for the Fall 2008 version of this class can be found at the HST.535 Fall 2008 website.)(Archived webcast lecture videos for the Fall 2008 version of this class can be found at the HST.535 Fall 2008 website.)
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-535-principles-and-practice-of-tissue-engineering-fall-2004/lecture-notes/)(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-535-principles-and-practice-of-tissue-engineering-fall-2004/lecture-notes/)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Introduction to Tissue Engineering in China|Scaffolds: Introduction|Scaffolds: Collagen-GAG Analogs of Extracellular Matrix|Cells: Liver Cells|Scaffolds: Free-Form Manufacturing|Scaffolds: Self-Assembled ProteinsIntroduction to Tissue Engineering in China|Scaffolds: Introduction|Scaffolds: Collagen-GAG Analogs of Extracellular Matrix|Cells: Liver Cells|Scaffolds: Free-Form Manufacturing|Scaffolds: Self-Assembled Proteins
Cells: Differentiated versus Stem Cells|Scaffolds: Biomimetics Design|Cells: Effects of Culture Conditions|Regulators: Gene Transfer Wedded to Tissue Engineering|Applications: Skin and Peripheral Nerve Regeneration|Nerve RepairCells: Differentiated versus Stem Cells|Scaffolds: Biomimetics Design|Cells: Effects of Culture Conditions|Regulators: Gene Transfer Wedded to Tissue Engineering|Applications: Skin and Peripheral Nerve Regeneration|Nerve Repair
Discussion: Clinical Applications|Discussion: Comparative Analysis of Tissue Engineering Strategies|Bone Regeneration|Cartilage Repair|Federal Regulatory Issues for Tissue Engineering Products in the U.S., China, and Other Countries|Discussion: Clinical Applications|Discussion: Comparative Analysis of Tissue Engineering Strategies|Bone Regeneration|Cartilage Repair|Federal Regulatory Issues for Tissue Engineering Products in the U.S., China, and Other Countries|
{table}{table}
h3 Fields, Forces, and Flows in Biological Systemsh3 Fields, Forces, and Flows in Biological Systems
(http://ocw.mit.edu/courses/biological-engineering/20-430j-fields-forces-and-flows-in-biological-systems-be-430j-fall-2004/)(http://ocw.mit.edu/courses/biological-engineering/20-430j-fields-forces-and-flows-in-biological-systems-be-430j-fall-2004/)
__Course Description__:__Course Description__:
This course covers the following topics: conduction, diffusion, convection in electrolytes; fields in heterogeneous media; electrical double layers; Maxwell stress tensor and electrical forces in physiological systems; and fluid and solid continua: equations of motion useful for porous, hydrated biological tissues. Case studies considered include membrane transport; electrode interfaces; electrical, mechanical, and chemical transduction in tissues; electrophoretic and electroosmotic flows; diffusion/reaction; and ECG. The course also examines electromechanical and physicochemical interactions in biomaterials and cells; orthopaedic, cardiovascular, and other clinical examples.This course covers the following topics: conduction, diffusion, convection in electrolytes; fields in heterogeneous media; electrical double layers; Maxwell stress tensor and electrical forces in physiological systems; and fluid and solid continua: equations of motion useful for porous, hydrated biological tissues. Case studies considered include membrane transport; electrode interfaces; electrical, mechanical, and chemical transduction in tissues; electrophoretic and electroosmotic flows; diffusion/reaction; and ECG. The course also examines electromechanical and physicochemical interactions in biomaterials and cells; orthopaedic, cardiovascular, and other clinical examples.
__Lecture Notes__:__Lecture Notes__:
(http://ocw.mit.edu/courses/biological-engineering/20-430j-fields-forces-and-flows-in-biological-systems-be-430j-fall-2004/lecture-notes/)(http://ocw.mit.edu/courses/biological-engineering/20-430j-fields-forces-and-flows-in-biological-systems-be-430j-fall-2004/lecture-notes/)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Continuity of Chemical Species, Flux, Reaction Rates, Boundary Conditions|Diffusion + Begin Reaction + Damkohler + Scaling and Approximations|Example Problems: Separation of Variables Method|Example Problems: Separation of Variables Method (cont.) + Case Study: IGF Problem from Lecture L1 using Matrix Continuum Distribution of IGF Binding Proteins + Numerical Considerations|Diffusion/Reaction + Add Cell Related (Receptor) Binding|Diffusion/Reaction + Examples of Numerical Approaches to Nonlinear ProblemsContinuity of Chemical Species, Flux, Reaction Rates, Boundary Conditions|Diffusion + Begin Reaction + Damkohler + Scaling and Approximations|Example Problems: Separation of Variables Method|Example Problems: Separation of Variables Method (cont.) + Case Study: IGF Problem from Lecture L1 using Matrix Continuum Distribution of IGF Binding Proteins + Numerical Considerations|Diffusion/Reaction + Add Cell Related (Receptor) Binding|Diffusion/Reaction + Examples of Numerical Approaches to Nonlinear Problems
IGF + E-field and Transport + Maxwell's Equations|Define Potential, Conservation of Charge + Electroquasistatics|Laplacian Solutions via Separation of Variables + Electrical Boundary Conditions, Ohmic Transport and Electrochemical Systems|Charge Relaxation + Electrical Double Layers + Poisson Boltzmann|Donnan Equilibrium in Tissues, Gels, Polyelectrolyte Networks|Charge Group Ionization and Electro-diffusion Reaction in Molecular NetworksIGF + E-field and Transport + Maxwell's Equations|Define Potential, Conservation of Charge + Electroquasistatics|Laplacian Solutions via Separation of Variables + Electrical Boundary Conditions, Ohmic Transport and Electrochemical Systems|Charge Relaxation + Electrical Double Layers + Poisson Boltzmann|Donnan Equilibrium in Tissues, Gels, Polyelectrolyte Networks|Charge Group Ionization and Electro-diffusion Reaction in Molecular Networks
Ligand Binding to Cell Receptors|Diffusion in Heterogeneous Media|Conservation of Mass and Momentum in Fluids|Newtonian, Fully Developed Low Reynold's Number Flows + Examples|Capillary Electroosmosis-Electrophoresis in MEMs and Microfluidics|Streaming Potentials + Begin ElectrophoresisLigand Binding to Cell Receptors|Diffusion in Heterogeneous Media|Conservation of Mass and Momentum in Fluids|Newtonian, Fully Developed Low Reynold's Number Flows + Examples|Capillary Electroosmosis-Electrophoresis in MEMs and Microfluidics|Streaming Potentials + Begin Electrophoresis
Convective Solute Transport|Hindered Transport in Membranes and Tissues|Coupled Fluid and Electrical Shear Stresses: Cell/Molecular Electrophoresis|Convective and Charge Relaxation Effects in Double Layers: Electrokinetics|DLVO Theory - Double Layer Repulsion and Molecular Interactions (Proteins, DNA, GAGs|Tissue/Molecular Swelling Stresses: Donnan (Macro) vs. Poisson Boltzmann (Nano)Convective Solute Transport|Hindered Transport in Membranes and Tissues|Coupled Fluid and Electrical Shear Stresses: Cell/Molecular Electrophoresis|Convective and Charge Relaxation Effects in Double Layers: Electrokinetics|DLVO Theory - Double Layer Repulsion and Molecular Interactions (Proteins, DNA, GAGs|Tissue/Molecular Swelling Stresses: Donnan (Macro) vs. Poisson Boltzmann (Nano)
{table}{table}
h3 Principles of Radiation Interactionsh3 Principles of Radiation Interactions
(http://ocw.mit.edu/courses/nuclear-engineering/22-55j-principles-of-radiation-interactions-fall-2004/)(http://ocw.mit.edu/courses/nuclear-engineering/22-55j-principles-of-radiation-interactions-fall-2004/)
__Course Description__:__Course Description__:
The central theme of this course is the interaction of radiation with biological material. The course is intended to provide a broad understanding of how different types of radiation deposit energy, including the creation and behavior of secondary radiations; of how radiation affects cells and why the different types of radiation have very different biological effects. Topics will include: the effects of radiation on biological systems including DNA damage; in vitro cell survival models; and in vivo mammalian systems. The course covers radiation therapy, radiation syndromes in humans and carcinogenesis. Environmental radiation sources on earth and in space, and aspects of radiation protection are also discussed. Examples from the current literature will be used to supplement lecture material.The central theme of this course is the interaction of radiation with biological material. The course is intended to provide a broad understanding of how different types of radiation deposit energy, including the creation and behavior of secondary radiations; of how radiation affects cells and why the different types of radiation have very different biological effects. Topics will include: the effects of radiation on biological systems including DNA damage; in vitro cell survival models; and in vivo mammalian systems. The course covers radiation therapy, radiation syndromes in humans and carcinogenesis. Environmental radiation sources on earth and in space, and aspects of radiation protection are also discussed. Examples from the current literature will be used to supplement lecture material.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/courses/nuclear-engineering/22-55j-principles-of-radiation-interactions-fall-2004/lecture-notes/)(http://ocw.mit.edu/courses/nuclear-engineering/22-55j-principles-of-radiation-interactions-fall-2004/lecture-notes/)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Radiation Interactions|Radiation Interactions|Radiation Chemistry/LET/Tracks|Effects on Chromosomes/DNA|Dose Response in Vitro: Cell Survival Curves|RBE/Clustered DamageRadiation Interactions|Radiation Interactions|Radiation Chemistry/LET/Tracks|Effects on Chromosomes/DNA|Dose Response in Vitro: Cell Survival Curves|RBE/Clustered Damage
Protons and Alphas of same LET|Dose Response in Vivo|Chemical Modification of Radiation Response|Cell, Tissue and Tumor Kinetics|Radiation Therapy: Tumor Radiobiology|Radiation Therapy (contd.): FractionationProtons and Alphas of same LET|Dose Response in Vivo|Chemical Modification of Radiation Response|Cell, Tissue and Tumor Kinetics|Radiation Therapy: Tumor Radiobiology|Radiation Therapy (contd.): Fractionation
Acute Effects of Whole Body Exposure|Late Effects: Chronic Exposure/Low Doses|Radiation Protection/Background Radiation/Radon|Alpha Particles/Bystander Effect|Microbeams|BNCT/Other ModalitiesAcute Effects of Whole Body Exposure|Late Effects: Chronic Exposure/Low Doses|Radiation Protection/Background Radiation/Radon|Alpha Particles/Bystander Effect|Microbeams|BNCT/Other Modalities
{table} {table}
h3 Biomedical Signal and Image Processingh3 Biomedical Signal and Image Processing
(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-582j-biomedical-signal-and-image-processing-spring-2007/)(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-582j-biomedical-signal-and-image-processing-spring-2007/)
__Course Description__:__Course Description__:
This course presents the fundamentals of digital signal processing with particular emphasis on problems in biomedical research and clinical medicine. It covers principles and algorithms for processing both deterministic and random signals. Topics include data acquisition, imaging, filtering, coding, feature extraction, and modeling. The focus of the course is a series of labs that provide practical experience in processing physiological data, with examples from cardiology, speech processing, and medical imaging. The labs are done in MATLAB® during weekly lab sessions that take place in an electronic classroom. Lectures cover signal processing topics relevant to the lab exercises, as well as background on the biological signals processed in the labs.This course presents the fundamentals of digital signal processing with particular emphasis on problems in biomedical research and clinical medicine. It covers principles and algorithms for processing both deterministic and random signals. Topics include data acquisition, imaging, filtering, coding, feature extraction, and modeling. The focus of the course is a series of labs that provide practical experience in processing physiological data, with examples from cardiology, speech processing, and medical imaging. The labs are done in MATLAB® during weekly lab sessions that take place in an electronic classroom. Lectures cover signal processing topics relevant to the lab exercises, as well as background on the biological signals processed in the labs.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-582j-biomedical-signal-and-image-processing-spring-2007/lecture-notes/)(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-582j-biomedical-signal-and-image-processing-spring-2007/lecture-notes/)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Data acquisition|Digital filtering|ECG|DTFT|DFT|Sampling revisitedData acquisition|Digital filtering|ECG|DTFT|DFT|Sampling revisited
Speech signals|Speech coding|Image processing I|PDFs|Image processing II|Estimating PDFsSpeech signals|Speech coding|Image processing I|PDFs|Image processing II|Estimating PDFs
Segmentation|Image registration I|Image registration II|Imaging modalities|Random signals I|Random signals IISegmentation|Image registration I|Image registration II|Imaging modalities|Random signals I|Random signals II
Blind source separation|||||Blind source separation|||||
{table}{table}
h3 Functional Magnetic Resonance Imaging: Data Acquisition and Analysish3 Functional Magnetic Resonance Imaging: Data Acquisition and Analysis
(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-583-functional-magnetic-resonance-imaging-data-acquisition-and-analysis-fall-2008/)(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-583-functional-magnetic-resonance-imaging-data-acquisition-and-analysis-fall-2008/)
__Course Description__:__Course Description__:
This team-taught multidisciplinary course provides information relevant to the conduct and interpretation of human brain mapping studies. It begins with in-depth coverage of the physics of image formation, mechanisms of image contrast, and the physiological basis for image signals. Parenchymal and cerebrovascular neuroanatomy and application of sophisticated structural analysis algorithms for segmentation and registration of functional data are discussed. Additional topics include: fMRI experimental design including block design, event related and exploratory data analysis methods, and building and applying statistical models for fMRI data; and human subject issues including informed consent, institutional review board requirements and safety in the high field environment.This team-taught multidisciplinary course provides information relevant to the conduct and interpretation of human brain mapping studies. It begins with in-depth coverage of the physics of image formation, mechanisms of image contrast, and the physiological basis for image signals. Parenchymal and cerebrovascular neuroanatomy and application of sophisticated structural analysis algorithms for segmentation and registration of functional data are discussed. Additional topics include: fMRI experimental design including block design, event related and exploratory data analysis methods, and building and applying statistical models for fMRI data; and human subject issues including informed consent, institutional review board requirements and safety in the high field environment.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-583-functional-magnetic-resonance-imaging-data-acquisition-and-analysis-fall-2008/lecture-notes/)(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-583-functional-magnetic-resonance-imaging-data-acquisition-and-analysis-fall-2008/lecture-notes/)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
MRI physics I|MRI physics II|MRI physics III|Imaging physiology I: brain at the baseline|Imaging physiology II: brain activation|Imaging physiology III: BOLD imagingMRI physics I|MRI physics II|MRI physics III|Imaging physiology I: brain at the baseline|Imaging physiology II: brain activation|Imaging physiology III: BOLD imaging
Imaging physiology IV: BOLD (cont.) and non-BOLD techniques|Stats 2: level 1|Stats 5: correction for multiple measures|Stats 7: causality|Quantitative neuroimaging biomarkers|Spatial normalization for group analysisImaging physiology IV: BOLD (cont.) and non-BOLD techniques|Stats 2: level 1|Stats 5: correction for multiple measures|Stats 7: causality|Quantitative neuroimaging biomarkers|Spatial normalization for group analysis
{table}{table}
h3 Biomedical Engineering Seminar Series: Developing Professional Skills h3 Biomedical Engineering Seminar Series: Developing Professional Skills
(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-590-biomedical-engineering-seminar-series-developing-professional-skills-fall-2006/)(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-590-biomedical-engineering-seminar-series-developing-professional-skills-fall-2006/)
__Course Description__:__Course Description__:
This course consists of a series of seminars focused on the development of professional skills. Each semester focuses on a different topic, resulting in a repeating cycle that covers medical ethics, responsible conduct of research, written and oral technical communication, and translational issues. Material and activities include guest lectures, case studies, interactive small group discussions, and role-playing simulations.This course consists of a series of seminars focused on the development of professional skills. Each semester focuses on a different topic, resulting in a repeating cycle that covers medical ethics, responsible conduct of research, written and oral technical communication, and translational issues. Material and activities include guest lectures, case studies, interactive small group discussions, and role-playing simulations.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-590-biomedical-engineering-seminar-series-developing-professional-skills-fall-2006/lecture-notes/)(http://ocw.mit.edu/courses/health-sciences-and-technology/hst-590-biomedical-engineering-seminar-series-developing-professional-skills-fall-2006/lecture-notes/)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Kick-off with an Introductory Workshop on CVs|You Applied for that Dream Job, and You got an Interview. Good Job! Now What?|Congratulations! You've Got the Job of Your Dreams-The Swanky Office, the Sweet Lab, the Dutiful Graduate Students. Now, You Have to Bring in the Grant Money to Support it All|The Day My Grant Got Rejected . . . .||Kick-off with an Introductory Workshop on CVs|You Applied for that Dream Job, and You got an Interview. Good Job! Now What?|Congratulations! You've Got the Job of Your Dreams-The Swanky Office, the Sweet Lab, the Dutiful Graduate Students. Now, You Have to Bring in the Grant Money to Support it All|The Day My Grant Got Rejected . . . .||
{table}{table}
h3 Speech Communicationh3 Speech Communication
(http://ocw.mit.edu/courses/electrical-engineering-and-computer-science/6-541j-speech-communication-spring-2004/)(http://ocw.mit.edu/courses/electrical-engineering-and-computer-science/6-541j-speech-communication-spring-2004/)
__Course Description__:__Course Description__:
Sppech Communication surveys the structural properties of natural languages, with special emphasis on the sound pattern. Topics covered include: representation of the lexicon; physiology of speech production; articulatory phonetics; acoustical theory of speech production; acoustical and articulatory descriptions of phonetic features and of prosodic aspects of speech; perception of speech; models of lexical access and of speech production and planning; and applications to recognition and generation of speech by machine, and to the study of speech disorders.Sppech Communication surveys the structural properties of natural languages, with special emphasis on the sound pattern. Topics covered include: representation of the lexicon; physiology of speech production; articulatory phonetics; acoustical theory of speech production; acoustical and articulatory descriptions of phonetic features and of prosodic aspects of speech; perception of speech; models of lexical access and of speech production and planning; and applications to recognition and generation of speech by machine, and to the study of speech disorders.
__Lecture Notes__:__Lecture Notes__:
(http://ocw.mit.edu/courses/electrical-engineering-and-computer-science/6-541j-speech-communication-spring-2004/lecture-notes/)(http://ocw.mit.edu/courses/electrical-engineering-and-computer-science/6-541j-speech-communication-spring-2004/lecture-notes/)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Introduction and Background|Methods of Approach to Study of Speech and Language: Speech Production, Acoustics, Perception, Segments and Features, Phonology, Syntax|Phonetic Transcription|Signal Processing for Speech|Survey of Speech Anatomy, Respiratory System, Airflows and Pressures|Auditory System and Human Response to SoundIntroduction and Background|Methods of Approach to Study of Speech and Language: Speech Production, Acoustics, Perception, Segments and Features, Phonology, Syntax|Phonetic Transcription|Signal Processing for Speech|Survey of Speech Anatomy, Respiratory System, Airflows and Pressures|Auditory System and Human Response to Sound
Some Basic Acoustics of Resonators and Sources, Source-filter Concepts|Vowels|Acoustic Source at the Glottis|Mechanism of Vocal-fold Vibration|Source Characteristics for Females and Males|Different Vocal-tract Shapes: Articulatory Attributes, Acoustic ConsequencesSome Basic Acoustics of Resonators and Sources, Source-filter Concepts|Vowels|Acoustic Source at the Glottis|Mechanism of Vocal-fold Vibration|Source Characteristics for Females and Males|Different Vocal-tract Shapes: Articulatory Attributes, Acoustic Consequences
Features High, Low, Back, and their Articulatory and Acoustic Correlates|Other Vowel Features: Rounding, Nasalization, Tense-lax|Laryngeal Variations for Vowels|Breathy and Pressed Voicing|Tones|StressFeatures High, Low, Back, and their Articulatory and Acoustic Correlates|Other Vowel Features: Rounding, Nasalization, Tense-lax|Laryngeal Variations for Vowels|Breathy and Pressed Voicing|Tones|Stress
Auditory Processing of Vowels|Consonants|Aerodynamics of the Vocal Tract, Turbulence Noise, Abrupt Release, Bursts|Place of Articulation for Consonants: Articulatory Attributes, Acoustic Consequences, Formant Transitions, Classification in Terms of Features|Aspiration and Voicing|Models of Stop, Nasal, and Fricative Consonant ProductionAuditory Processing of Vowels|Consonants|Aerodynamics of the Vocal Tract, Turbulence Noise, Abrupt Release, Bursts|Place of Articulation for Consonants: Articulatory Attributes, Acoustic Consequences, Formant Transitions, Classification in Terms of Features|Aspiration and Voicing|Models of Stop, Nasal, and Fricative Consonant Production
Perception of Consonants|Liquids, Glides, Clicks, Other Features|Consonants and Consonant Sequences in Various Contexts|Introduction to Syntax, Morphology and Phonology|Review of Features and Feature Hierarchies; Feature Geometry and its Relation to Speech Production|Phonological Evidence for Distinctive FeaturesPerception of Consonants|Liquids, Glides, Clicks, Other Features|Consonants and Consonant Sequences in Various Contexts|Introduction to Syntax, Morphology and Phonology|Review of Features and Feature Hierarchies; Feature Geometry and its Relation to Speech Production|Phonological Evidence for Distinctive Features
Lexical Representation|Examples from English and Other Languages|Prosody|Models of Speech Planning; Evidence from Speech Errors|Modification of Features and Acoustic Properties in Fluent Speech|Gestural Overlap, Reduction, EnhancementLexical Representation|Examples from English and Other Languages|Prosody|Models of Speech Planning; Evidence from Speech Errors|Modification of Features and Acoustic Properties in Fluent Speech|Gestural Overlap, Reduction, Enhancement
Approaches to Lexical Access|Models of Human and Machine Recognition of Speech|Impaired Speech Production and Perception|Hearing Loss, Aphasia, Neurogenic Disorders, Laryngeal Disorders, Other Impairments|Aids for Speech and Hearing-impaired|Speech and Language Development in ChildrenApproaches to Lexical Access|Models of Human and Machine Recognition of Speech|Impaired Speech Production and Perception|Hearing Loss, Aphasia, Neurogenic Disorders, Laryngeal Disorders, Other Impairments|Aids for Speech and Hearing-impaired|Speech and Language Development in Children
Acoustic Analysis of Children's Speech|||||Acoustic Analysis of Children's Speech|||||
{table}{table}
h3 Acoustics of Speech and Hearingh3 Acoustics of Speech and Hearing
(http://ocw.mit.edu/courses/electrical-engineering-and-computer-science/6-551j-acoustics-of-speech-and-hearing-fall-2004/)(http://ocw.mit.edu/courses/electrical-engineering-and-computer-science/6-551j-acoustics-of-speech-and-hearing-fall-2004/)
__Course Description__:__Course Description__:
The Acoustics of Speech and Hearing is an H-Level graduate course that reviews the physical processes involved in the production, propagation and reception of human speech. Particular attention is paid to how the acoustics and mechanics of the speech and auditory system define what sounds we are capable of producing and what sounds we can sense. Areas of discussion include:The Acoustics of Speech and Hearing is an H-Level graduate course that reviews the physical processes involved in the production, propagation and reception of human speech. Particular attention is paid to how the acoustics and mechanics of the speech and auditory system define what sounds we are capable of producing and what sounds we can sense. Areas of discussion include:
1.the acoustic cues used in determining the direction of a sound source,1.the acoustic cues used in determining the direction of a sound source,
2.the acoustic and mechanical mechanisms involved in speech production and2.the acoustic and mechanical mechanisms involved in speech production and
3.the acoustic and mechanical mechanism used to transduce and analyze sounds in the ear.3.the acoustic and mechanical mechanism used to transduce and analyze sounds in the ear.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/courses/electrical-engineering-and-computer-science/6-551j-acoustics-of-speech-and-hearing-fall-2004/lecture-notes/)(http://ocw.mit.edu/courses/electrical-engineering-and-computer-science/6-551j-acoustics-of-speech-and-hearing-fall-2004/lecture-notes/)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Sound Measurement: Amplitude, Frequency and Phase of Simple and Complex Sounds (rms vs peak, FFT and Spectrum, Relationship between Time Waveform, FFT and Impulse Response)|Lumped Elements and Waves|Sound Propagation in Space 1: Plane Waves, Characteristic Impedance, Traveling Waves, Trading of Time and Space|Sound Propagation in Space 2: Spherical Waves, Multiple Sources|Diffraction of Sound, Localization Cues|Circuits 1: Lumped ElementsSound Measurement: Amplitude, Frequency and Phase of Simple and Complex Sounds (rms vs peak, FFT and Spectrum, Relationship between Time Waveform, FFT and Impulse Response)|Lumped Elements and Waves|Sound Propagation in Space 1: Plane Waves, Characteristic Impedance, Traveling Waves, Trading of Time and Space|Sound Propagation in Space 2: Spherical Waves, Multiple Sources|Diffraction of Sound, Localization Cues|Circuits 1: Lumped Elements
Circuits 2: Combinations of Elements|Circuits 3: Equivalent Circuits|Circuits 4: The Loudspeaker|Circuits 5: Microphones and Middle Ears|The Normal and Diseased Middle Ear|Tubes 1: Dimensional Equations, Natural FrequenciesCircuits 2: Combinations of Elements|Circuits 3: Equivalent Circuits|Circuits 4: The Loudspeaker|Circuits 5: Microphones and Middle Ears|The Normal and Diseased Middle Ear|Tubes 1: Dimensional Equations, Natural Frequencies
Tubes 2: Perturbation Theory|Tubes 3: Non-Uniformities and Losses|Speech Production 1: Vowels|Speech Production 2: Fricative Sources and Consonants|Speech Sound Production 3: More Consonants|Speech PerceptionTubes 2: Perturbation Theory|Tubes 3: Non-Uniformities and Losses|Speech Production 1: Vowels|Speech Production 2: Fricative Sources and Consonants|Speech Sound Production 3: More Consonants|Speech Perception
{table}{table}
h3 h3 Brain Mechanisms for Hearing and Speech
 (http://ocw.mit.edu/courses/health-sciences-and-technology/hst-722j-brain-mechanisms-for-hearing-and-speech-fall-2005/)
 
 __Course Description__:
 An advanced course covering anatomical, physiological, behavioral, and computational studies of the central nervous system relevant to speech and hearing. Students learn primarily by discussions of scientific papers on topics of current interest. Recent topics include cell types and neural circuits in the auditory brainstem, organization and processing in the auditory cortex, auditory reflexes and descending systems, functional imaging of the human auditory system, quantitative methods for relating neural responses to behavior, speech motor control, cortical representation of language, and auditory learning in songbirds.
 
 __Selected Lecture Notes__:
 (http://ocw.mit.edu/courses/health-sciences-and-technology/hst-722j-brain-mechanisms-for-hearing-and-speech-fall-2005/lecture-notes/)
 
 {table}
 Column1 | Column2 | Column3 | Column4 | Column5 | Column6
 Dorsal Cochlear Nucleus|Quantitative Methods|Neuroimaging|Speech Motor Control||
 {table}
 
 h3
()()
__Course Description__:__Course Description__:
__Selected Lecture Notes__:__Selected Lecture Notes__:
()()
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
{table}{table}
h3h3
()()
__Course Description__:__Course Description__:
__Selected Lecture Notes__:__Selected Lecture Notes__:
()()
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
{table}{table}
h3h3
()()
__Course Description__:__Course Description__:
__Selected Lecture Notes__:__Selected Lecture Notes__:
()()
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
{table}{table}
h3h3
()()
__Course Description__:__Course Description__:
__Selected Lecture Notes__:__Selected Lecture Notes__:
()()
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
{table}{table}
 
 h3
 ()
 
 __Course Description__:
 
 __Selected Lecture Notes__:
 ()
 
 {table}
 Column1 | Column2 | Column3 | Column4 | Column5 | Column6
 
 {table}
 
 h3
 ()
 
 __Course Description__:
 
 __Selected Lecture Notes__:
 ()
 
 {table}
 Column1 | Column2 | Column3 | Column4 | Column5 | Column6
 
 {table}
 
 h3
 ()
 
 __Course Description__:
 
 __Selected Lecture Notes__:
 ()
 
 {table}
 Column1 | Column2 | Column3 | Column4 | Column5 | Column6
 
 {table}
 
 h3
 ()
 
 __Course Description__:
 
 __Selected Lecture Notes__:
 ()
 
 {table}
 Column1 | Column2 | Column3 | Column4 | Column5 | Column6
 
 {table}
 
 h3
 ()
 
 __Course Description__:
 
 __Selected Lecture Notes__:
 ()
 
 {table}
 Column1 | Column2 | Column3 | Column4 | Column5 | Column6
 
 {table}
 
 h3
 ()
 
 __Course Description__:
 
 __Selected Lecture Notes__:
 ()
 
 {table}
 Column1 | Column2 | Column3 | Column4 | Column5 | Column6
 
 {table}
 
 h3
 ()
 
 __Course Description__:
 
 __Selected Lecture Notes__:
 ()
 
 {table}
 Column1 | Column2 | Column3 | Column4 | Column5 | Column6
 
 {table}
 
 h3
 ()
 
 __Course Description__:
 
 __Selected Lecture Notes__:
 ()
 
 {table}
 Column1 | Column2 | Column3 | Column4 | Column5 | Column6
 
 {table}
 
 h3
 ()
 
 __Course Description__:
 
 __Selected Lecture Notes__:
 ()
 
 {table}
 Column1 | Column2 | Column3 | Column4 | Column5 | Column6
 
 {table}
 
 h3
 ()
 
 __Course Description__:
 
 __Selected Lecture Notes__:
 ()
 
 {table}
 Column1 | Column2 | Column3 | Column4 | Column5 | Column6
 
 {table}
 
 h3
 ()
 
 __Course Description__:
 
 __Selected Lecture Notes__:
 ()
 
 {table}
 Column1 | Column2 | Column3 | Column4 | Column5 | Column6
 
 {table}
 
 h3
 ()
 
 __Course Description__:
 
 __Selected Lecture Notes__:
 ()
 
 {table}
 Column1 | Column2 | Column3 | Column4 | Column5 | Column6
 
 {table}
 
 h3
 ()
 
 __Course Description__:
 
 __Selected Lecture Notes__:
 ()
 
 {table}
 Column1 | Column2 | Column3 | Column4 | Column5 | Column6
 
 {table}
Key
Deleted  
Changed
  Added