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Version 41
(modified: 13 May 2010 10:19:36 AM by Gillian Stevens (t0022212)
Version 42
(modified: 13 May 2010 10:30:23 AM by Gillian Stevens (t0022212)
h1 Courses of Interest:h1 Courses of Interest:
(http://ocw.mit.edu/OcwWeb/web/courses/courses/index.htm#top)(http://ocw.mit.edu/OcwWeb/web/courses/courses/index.htm#top)
h2 Biological Engineeringh2 Biological Engineering
h3 Macroepidemiologyh3 Macroepidemiology
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-102Spring-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-102Spring-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course presents a challenging multi-dimensional perspective on the causes of human disease and mortality. The course focuses on analyses of major causes of mortality in the US since 1900: cancer, cardiovascular and cerebrovascular diseases, diabetes, and infectious diseases.This course presents a challenging multi-dimensional perspective on the causes of human disease and mortality. The course focuses on analyses of major causes of mortality in the US since 1900: cancer, cardiovascular and cerebrovascular diseases, diabetes, and infectious diseases.
h3 Chemicals in the Environment: Toxicology and Public Healthh3 Chemicals in the Environment: Toxicology and Public Health
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-104JSpring-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-104JSpring-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course addresses the challenges of defining a relationship between exposure to environmental chemicals and human disease. Course topics include epidemiological approaches to understanding disease causation; biostatistical methods; evaluation of human exposure to chemicals, and their internal distribution, metabolism, reactions with cellular components, and biological effects; and qualitative and quantitative health risk assessment methods used in the U.S. as bases for regulatory decision-making.This course addresses the challenges of defining a relationship between exposure to environmental chemicals and human disease. Course topics include epidemiological approaches to understanding disease causation; biostatistical methods; evaluation of human exposure to chemicals, and their internal distribution, metabolism, reactions with cellular components, and biological effects; and qualitative and quantitative health risk assessment methods used in the U.S. as bases for regulatory decision-making.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-104JSpring-2005/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-104JSpring-2005/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Introductory Lecture|Watch film A Civil Action|From the Real World to Hollywood and Back Again|Epidemiology: Persons, Places, and Time|Epidemiology: Test Development and Relative Risk|Biostatistics: Concepts in Variance Introductory Lecture|Watch film A Civil Action|From the Real World to Hollywood and Back Again|Epidemiology: Persons, Places, and Time|Epidemiology: Test Development and Relative Risk|Biostatistics: Concepts in Variance
Biostatistics: Distribution and the Mean|Confidence Intervals|Biostatistics: Detecting Differences and Correlations|Biostatistics: Poisson Analyses and Power|Environetics: Cause and Effect|Environetics: Study Design - Retrospective versus ProspectiveBiostatistics: Distribution and the Mean|Confidence Intervals|Biostatistics: Detecting Differences and Correlations|Biostatistics: Poisson Analyses and Power|Environetics: Cause and Effect|Environetics: Study Design - Retrospective versus Prospective
Environetics: Putting it all together - Evaluating Studies|Evaluating Environmental Causes of Mesothelioma|Quantitative Risk Assessment 1|Quantitative Risk Assessment 2|Toxicology 1|Toxicology 2Environetics: Putting it all together - Evaluating Studies|Evaluating Environmental Causes of Mesothelioma|Quantitative Risk Assessment 1|Quantitative Risk Assessment 2|Toxicology 1|Toxicology 2
Toxicology 3|Toxicology 4|Toxicology 5|Quantitative Risk Assessment 3|Quantitative Risk Assessment 4|Toxicology 3|Toxicology 4|Toxicology 5|Quantitative Risk Assessment 3|Quantitative Risk Assessment 4|
{table}{table}
h3 Systems Microbiologyh3 Systems Microbiology
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-106JFall-2006/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-106JFall-2006/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course covers introductory microbiology from a systems perspective, considering microbial diversity, population dynamics, and genomics. Emphasis is placed on the delicate balance between microbes and humans, and the changes that result in the emergence of infectious diseases and antimicrobial resistance. The case study approach covers such topics as vaccines, toxins, biodefense, and infections including Legionnaire’s disease, tuberculosis, Helicobacter pylori, and plague.This course covers introductory microbiology from a systems perspective, considering microbial diversity, population dynamics, and genomics. Emphasis is placed on the delicate balance between microbes and humans, and the changes that result in the emergence of infectious diseases and antimicrobial resistance. The case study approach covers such topics as vaccines, toxins, biodefense, and infections including Legionnaire’s disease, tuberculosis, Helicobacter pylori, and plague.
__Lecture Notes__:__Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-106JFall-2006/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-106JFall-2006/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Early Earth/Microbial Evolution|Cell Structure/Function|Biological Energy Conservation|Microbial Growth|Metabolic Regulation|VirologyEarly Earth/Microbial Evolution|Cell Structure/Function|Biological Energy Conservation|Microbial Growth|Metabolic Regulation|Virology
Information Flow in Biological Systems|Regulation of Cell Activity|Genetic Exchange in Bacteria|Experimental Evolution: Optimization of Metabolic Systems|Genomics I|Genomics IIInformation Flow in Biological Systems|Regulation of Cell Activity|Genetic Exchange in Bacteria|Experimental Evolution: Optimization of Metabolic Systems|Genomics I|Genomics II
Metabolic Diversity I|Metabolic Diversity II|Microbial Ecology|Microbial Growth Control|Microbe-host Interactions|Immunology IMetabolic Diversity I|Metabolic Diversity II|Microbial Ecology|Microbial Growth Control|Microbe-host Interactions|Immunology I
Immunology II|Diagnostic Microbiology|Person-to-person Transmission|Epidemiology|Animal- and Arthropod-transmitted Diseases|ReviewImmunology II|Diagnostic Microbiology|Person-to-person Transmission|Epidemiology|Animal- and Arthropod-transmitted Diseases|Review
{table}{table}
h3 Mechanisms of Drug Actionsh3 Mechanisms of Drug Actions
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-201Fall-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-201Fall-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course covers the chemical and biological analysis of the metabolism and distribution of drugs, toxins and chemicals in animals and humans, and the mechanism by which they cause therapeutic and toxic responses. Metabolism and toxicity as a basis for drug development is also covered.This course covers the chemical and biological analysis of the metabolism and distribution of drugs, toxins and chemicals in animals and humans, and the mechanism by which they cause therapeutic and toxic responses. Metabolism and toxicity as a basis for drug development is also covered.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-201Fall-2005/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-201Fall-2005/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Introduction and Principles|Chemistry/Biochemistry Review|Overview of Drug Development|Uptake/Transport/Distribution of Drugs|Drug Transporters|Bioethics SeminarIntroduction and Principles|Chemistry/Biochemistry Review|Overview of Drug Development|Uptake/Transport/Distribution of Drugs|Drug Transporters|Bioethics Seminar
Drug Transporters (cont.)|Introduction to Drug Metabolism|Liver Lecture|Drug Metabolism 2|Drug Metabolism 3|Drug Metabolism 4|Drug Transporters (cont.)|Introduction to Drug Metabolism|Liver Lecture|Drug Metabolism 2|Drug Metabolism 3|Drug Metabolism 4|
Oxygen Radicals in Drug Toxicity|Drug Toxicities|Drug Toxicities (cont.)|Bioethics Seminar|Pharmacokinetics|Pharmacokinetics (cont.)Oxygen Radicals in Drug Toxicity|Drug Toxicities|Drug Toxicities (cont.)|Bioethics Seminar|Pharmacokinetics|Pharmacokinetics (cont.)
Receptors and Case Study - Omeprazole|Case Study - Omeprazole|Case Study - Omeprazole (cont.)|Case Study - Acetaminophen|Case Study - Acetaminophen (cont.)|Case Study - StatinsReceptors and Case Study - Omeprazole|Case Study - Omeprazole|Case Study - Omeprazole (cont.)|Case Study - Acetaminophen|Case Study - Acetaminophen (cont.)|Case Study - Statins
Case Study - Statins (cont.)|Drug Industry Seminar|Case Study - Statins (cont.)|||Case Study - Statins (cont.)|Drug Industry Seminar|Case Study - Statins (cont.)|||
{table}{table}
h3 Molecular and Cellular Pathophysiologyh3 Molecular and Cellular Pathophysiology
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-450Spring-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-450Spring-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course focuses on the fundamentals of tissue and organ response to injury from a molecular and cellular perspective. There is a special emphasis on disease states that bridge infection, inflammation, immunity, and cancer. The systems approach to pathophysiology includes lectures, critical evaluation of recent scientific papers, and student projects and presentations.This course focuses on the fundamentals of tissue and organ response to injury from a molecular and cellular perspective. There is a special emphasis on disease states that bridge infection, inflammation, immunity, and cancer. The systems approach to pathophysiology includes lectures, critical evaluation of recent scientific papers, and student projects and presentations.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-450Spring-2005/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-450Spring-2005/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Introduction to 20.450 and HCC|Cellular Pathology|Inflammation|Liver Anatomy and Histology|Immunity|NeoplasiaIntroduction to 20.450 and HCC|Cellular Pathology|Inflammation|Liver Anatomy and Histology|Immunity|Neoplasia
Neoplasia (cont.)|Infectious Diseases|Liver and Biliary|Hepatocarcinogenesis|Animal Models|Special TopicNeoplasia (cont.)|Infectious Diseases|Liver and Biliary|Hepatocarcinogenesis|Animal Models|Special Topic
{table}{table}
h3 Design of Medical Devices and Implantsh3 Design of Medical Devices and Implants
(http://ocw.mit.edu/OcwWeb/Mechanical-Engineering/2-782JSpring-2006/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Mechanical-Engineering/2-782JSpring-2006/CourseHome/index.htm)
__Course Description__:__Course Description__:
This design course targets the solution of clinical problems by use of implants and other medical devices. Topics include the systematic use of cell-matrix control volumes; the role of stress analysis in the design process; anatomic fit, shape and size of implants; selection of biomaterials; instrumentation for surgical implantation procedures; preclinical testing for safety and efficacy, including risk/benefit ratio assessment evaluation of clinical performance and design of clinical trials.This design course targets the solution of clinical problems by use of implants and other medical devices. Topics include the systematic use of cell-matrix control volumes; the role of stress analysis in the design process; anatomic fit, shape and size of implants; selection of biomaterials; instrumentation for surgical implantation procedures; preclinical testing for safety and efficacy, including risk/benefit ratio assessment evaluation of clinical performance and design of clinical trials.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Mechanical-Engineering/2-782JSpring-2006/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Mechanical-Engineering/2-782JSpring-2006/LectureNotes/index.htm)
__I. Principles Of Implant Design (Working Paradigms)____I. Principles Of Implant Design (Working Paradigms)__
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Clinical Problems Requiring Implants for Solution|Principles of Implant Design / Design Parameters: Permanent versus Absorbable Devices|The Missing Organ and its Replacement|Criteria for Materials Selection|Tissue Engineering I: Scaffolds|Tissue Engineering II: Cells and RegulatorsClinical Problems Requiring Implants for Solution|Principles of Implant Design / Design Parameters: Permanent versus Absorbable Devices|The Missing Organ and its Replacement|Criteria for Materials Selection|Tissue Engineering I: Scaffolds|Tissue Engineering II: Cells and Regulators
Case Study of Organ Regeneration|||||Case Study of Organ Regeneration|||||
{table}{table}
__II. Design Parameters__ __II. Design Parameters__
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Design Specifications: Biomaterials Survey|Biocompatibility: Local and Systemic Effects|Design Specifications: Tissue Bonding and Modulus Matching|Degradation of Devices: Natural and Synthetic Polymers|Biocompatibility: Scar Formation and Contraction|Degradation of Devices: Corrosion and WearDesign Specifications: Biomaterials Survey|Biocompatibility: Local and Systemic Effects|Design Specifications: Tissue Bonding and Modulus Matching|Degradation of Devices: Natural and Synthetic Polymers|Biocompatibility: Scar Formation and Contraction|Degradation of Devices: Corrosion and Wear
Federal Regulation of Devices I|Oral Presentations of Proposals for Design II|Federal Regulation of Devices II|||Federal Regulation of Devices I|Oral Presentations of Proposals for Design II|Federal Regulation of Devices II|||
{table}{table}
__III. Design Solution In-use__ __III. Design Solution In-use__
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Scaffolds for Cartilage Repair|Implants for Bone|Implants for Plastic Surgery|Cardiovascular Prostheses: Heart Valves and Blood Vessels|Devices for Nerve Regeneration|Musculoskeletal Soft Tissues: Meniscus, Intervertebral DiskScaffolds for Cartilage Repair|Implants for Bone|Implants for Plastic Surgery|Cardiovascular Prostheses: Heart Valves and Blood Vessels|Devices for Nerve Regeneration|Musculoskeletal Soft Tissues: Meniscus, Intervertebral Disk
Dental and Otologic Implants|Other Devices: Spinal Cord, Heart Lung|Final Oral Presentation of Designs (Mock FDA Panel)|||Dental and Otologic Implants|Other Devices: Spinal Cord, Heart Lung|Final Oral Presentation of Designs (Mock FDA Panel)|||
{table}{table}
h3 Molecular Principles of Biomaterialsh3 Molecular Principles of Biomaterials
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-462JSpring-2006/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-462JSpring-2006/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course covers the analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces.This course covers the analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-462JSpring-2006/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-462JSpring-2006/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Biodegradable Polymeric Solids|Biodegradable Polymeric Solids|Controlled Release Devices|Controlled Release Devices (cont.)|Case Studies in Complex Controlled Release|Hydrogels as BiomaterialsBiodegradable Polymeric Solids|Biodegradable Polymeric Solids|Controlled Release Devices|Controlled Release Devices (cont.)|Case Studies in Complex Controlled Release|Hydrogels as Biomaterials
Hydrogels as Biomaterials (cont.)|Hydrogels as Biomaterials (cont.)|Hydrogels as Biomaterials (cont.)|Hydrogels as Biomaterials (cont.)|Engineering Biological Recognition of Biomaterials|Engineering Biological Recognition of Biomaterials (cont.)Hydrogels as Biomaterials (cont.)|Hydrogels as Biomaterials (cont.)|Hydrogels as Biomaterials (cont.)|Hydrogels as Biomaterials (cont.)|Engineering Biological Recognition of Biomaterials|Engineering Biological Recognition of Biomaterials (cont.)
Engineering Biological Recognition of Biomaterials (cont.)|Bioceramics and Biocomposites|Bioceramics and Biocomposites (cont.)|Bioceramics and Biocomposites (cont.)|Molecular Devices|Nanoparticle and Microparticle Biomolecule Drug CarriersEngineering Biological Recognition of Biomaterials (cont.)|Bioceramics and Biocomposites|Bioceramics and Biocomposites (cont.)|Bioceramics and Biocomposites (cont.)|Molecular Devices|Nanoparticle and Microparticle Biomolecule Drug Carriers
Nanoparticle and Microparticle Biomolecule Drug Carriers (cont.)|Basic Biology of Vaccination and Viral Infections|Basic Biology of Vaccination and Viral Infections (cont.)|Drug Targeting and Intracellular Drug Delivery for Vaccines|Drug Targeting and Intracellular Drug Delivery for Vaccines (cont.)|DNA VaccinesNanoparticle and Microparticle Biomolecule Drug Carriers (cont.)|Basic Biology of Vaccination and Viral Infections|Basic Biology of Vaccination and Viral Infections (cont.)|Drug Targeting and Intracellular Drug Delivery for Vaccines|Drug Targeting and Intracellular Drug Delivery for Vaccines (cont.)|DNA Vaccines
DNA Vaccines (cont.)|||||DNA Vaccines (cont.)|||||
{table}{table}
h2 Biologyh2 Biology
h3 Genetics h3 Genetics
(http://ocw.mit.edu/OcwWeb/Biology/7-03Fall-2004/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Biology/7-03Fall-2004/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course discusses the principles of genetics with application to the study of biological function at the level of molecules, cells, and multicellular organisms, including humans. The topics include: structure and function of genes, chromosomes and genomes, biological variation resulting from recombination, mutation, and selection, population genetics, use of genetic methods to analyze protein function, gene regulation and inherited disease.This course discusses the principles of genetics with application to the study of biological function at the level of molecules, cells, and multicellular organisms, including humans. The topics include: structure and function of genes, chromosomes and genomes, biological variation resulting from recombination, mutation, and selection, population genetics, use of genetic methods to analyze protein function, gene regulation and inherited disease.
__Lecture Notes__:__Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Biology/7-03Fall-2004/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Biology/7-03Fall-2004/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Physical Structure of the Gene|The Complementation Test and Gene Function|Mendelian Genetics|Probability and Pedigrees|Chromosomes and Sex Linkage|Recombination and Genetic MapsPhysical Structure of the Gene|The Complementation Test and Gene Function|Mendelian Genetics|Probability and Pedigrees|Chromosomes and Sex Linkage|Recombination and Genetic Maps
Three-factor Crosses|Tetrad Analysis|Phage Genetics|Gene Structure and DNA Analysis|Mutations and Suppressors|Bacterial Genetics: TranspositionThree-factor Crosses|Tetrad Analysis|Phage Genetics|Gene Structure and DNA Analysis|Mutations and Suppressors|Bacterial Genetics: Transposition
Bacterial Genetics: Transduction|Complementation in Bacteria: Plasmids|Complementation in Bacteria: Recombinant DNA|Prokaryotic Regulation: Negative Control|Prokaryotic Regulation: Positive Control|Prokaryotic Regulation: Regulatory CircuitsBacterial Genetics: Transduction|Complementation in Bacteria: Plasmids|Complementation in Bacteria: Recombinant DNA|Prokaryotic Regulation: Negative Control|Prokaryotic Regulation: Positive Control|Prokaryotic Regulation: Regulatory Circuits
Eukaryotic Genes and Genomes I|Eukaryotic Genes and Genomes II|Eukaryotic Genes and Genomes III|Eukaryotic Genes and Genomes IV|Transgenes and Gene Targeting in Mice I|Transgenes and Gene Targeting in Mice IIEukaryotic Genes and Genomes I|Eukaryotic Genes and Genomes II|Eukaryotic Genes and Genomes III|Eukaryotic Genes and Genomes IV|Transgenes and Gene Targeting in Mice I|Transgenes and Gene Targeting in Mice II
Population Genetics: Hardy-Weinberg|Population Genetics: Mutation and Selection|Population Genetics: Inbreeding|Human Polymorphisms|Statistical Evaluation of Linkage I|Statistical Evaluation of Linkage IIPopulation Genetics: Hardy-Weinberg|Population Genetics: Mutation and Selection|Population Genetics: Inbreeding|Human Polymorphisms|Statistical Evaluation of Linkage I|Statistical Evaluation of Linkage II
Complex Traits|Chromosome Anomalies I|Chromosome Anomalies II|Genetics of Cancer I|Genetics of Cancer II||Complex Traits|Chromosome Anomalies I|Chromosome Anomalies II|Genetics of Cancer I|Genetics of Cancer II||
{table}{table}
h3 Topics in Experimental Biologyh3 Topics in Experimental Biology
(http://ocw.mit.edu/OcwWeb/Biology/7-18Fall-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Biology/7-18Fall-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
This independent experimental study course is designed to allow students with a strong interest in independent research to fulfill the project laboratory requirement for the Biology Department Program in the context of a research laboratory at MIT. The research should be a continuation of a previous project under the direction of a member of the Biology Department faculty.This independent experimental study course is designed to allow students with a strong interest in independent research to fulfill the project laboratory requirement for the Biology Department Program in the context of a research laboratory at MIT. The research should be a continuation of a previous project under the direction of a member of the Biology Department faculty.
This course provides instruction and practice in written and oral communication. Journal club discussions are used to help students evaluate and write scientific papers.This course provides instruction and practice in written and oral communication. Journal club discussions are used to help students evaluate and write scientific papers.
__Lecture Notes__:__Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Biology/7-18Fall-2005/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Biology/7-18Fall-2005/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Impromptu Description of Research Project, Logic of a Paragraph|Logic of a Research Paper, Organization of a Research Proposal, How to Present Data in a Lab Talk|Data and Figures, Results and Preliminary Results|Project Outline and Journal Club|Introduction, Background and Significance|Experimental PlanImpromptu Description of Research Project, Logic of a Paragraph|Logic of a Research Paper, Organization of a Research Proposal, How to Present Data in a Lab Talk|Data and Figures, Results and Preliminary Results|Project Outline and Journal Club|Introduction, Background and Significance|Experimental Plan
Discussion of Paragraphs, Ethical Conduct of Science, Citations and Plagiarism|Methods and Materials|Scientific and Non-scientific Abstract|Discussion (cont.) and Polishing your Writing||Discussion of Paragraphs, Ethical Conduct of Science, Citations and Plagiarism|Methods and Materials|Scientific and Non-scientific Abstract|Discussion (cont.) and Polishing your Writing||
{table}{table}
h3 Cellular Neurobiologyh3 Cellular Neurobiology
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-09JSpring-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-09JSpring-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course serves as an introduction to the structure and function of the nervous system. Emphasis is placed on the cellular properties of neurons and other excitable cells. Topics covered include the structure and biophysical properties of excitable cells, synaptic transmission, neurochemistry, neurodevelopment, and the integration of information in simple systems and the visual system.This course serves as an introduction to the structure and function of the nervous system. Emphasis is placed on the cellular properties of neurons and other excitable cells. Topics covered include the structure and biophysical properties of excitable cells, synaptic transmission, neurochemistry, neurodevelopment, and the integration of information in simple systems and the visual system.
__Lecture Notes__:__Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-09JSpring-2005/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-09JSpring-2005/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Introduction to the Nervous System|Membrane Channels and Signaling|Ionic basis of the Resting Potential|Action Potential I|Action Potential II|Neurons as Conductors: Propagation of the Action PotentialIntroduction to the Nervous System|Membrane Channels and Signaling|Ionic basis of the Resting Potential|Action Potential I|Action Potential II|Neurons as Conductors: Propagation of the Action Potential
Electrical and Chemical Synaptic Transmission|Mechanisms of Transmitter Release at Synapses|Indirect Mechanisms of Synaptic Transmission|Biochemistry of Synaptic Transmission|Learning and Memory I|Learning and Memory IIElectrical and Chemical Synaptic Transmission|Mechanisms of Transmitter Release at Synapses|Indirect Mechanisms of Synaptic Transmission|Biochemistry of Synaptic Transmission|Learning and Memory I|Learning and Memory II
From Genes to Structure to Behavior|Nervous System Development I|Nervous System Development II|Axon Guidance I|Synapse Formation|Fine-Tuning Synaptic ConnectionsFrom Genes to Structure to Behavior|Nervous System Development I|Nervous System Development II|Axon Guidance I|Synapse Formation|Fine-Tuning Synaptic Connections
Vision I|Vision II|Hearing|Olfaction and Other Sensory Systems|Pain and Thermoreception|Higher Order Cognitive FunctionVision I|Vision II|Hearing|Olfaction and Other Sensory Systems|Pain and Thermoreception|Higher Order Cognitive Function
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h3 Ubiquitination: The Proteasome and Human Diseaseh3 Ubiquitination: The Proteasome and Human Disease
(http://ocw.mit.edu/OcwWeb/Biology/7-340Fall-2004/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Biology/7-340Fall-2004/CourseHome/index.htm)
__Course Description__:__Course Description__:
This seminar provides a deeper understanding of the post-translational mechanisms evolved by eukaryotic cells to target proteins for degradation. Students learn how proteins are recognized and degraded by specific machinery (the proteasome) through their previous tagging with another small protein, ubiquitin. Additional topics include principles of ubiquitin-proteasome function, its control of the most important cellular pathways, and the implication of this system in different human diseases. Finally, speculation on the novel techniques that arose from an increased knowledge of the ubiquitin-proteosome system and current applications in the design of new pharmacological agents to battle disease is also covered.This seminar provides a deeper understanding of the post-translational mechanisms evolved by eukaryotic cells to target proteins for degradation. Students learn how proteins are recognized and degraded by specific machinery (the proteasome) through their previous tagging with another small protein, ubiquitin. Additional topics include principles of ubiquitin-proteasome function, its control of the most important cellular pathways, and the implication of this system in different human diseases. Finally, speculation on the novel techniques that arose from an increased knowledge of the ubiquitin-proteosome system and current applications in the design of new pharmacological agents to battle disease is also covered.
__Lecture Notes__:__Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Biology/7-340Fall-2004/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Biology/7-340Fall-2004/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Introduction|Discovery of the Ubiquitin Conjugation System|Protein Degradation in Trafficking Membranes I: Endoplasmic Reticulum Associated Degradation (ERAD) Pathway|Protein Degradation in Trafficking Membranes II: Endocytosis and lysosomal Degradation|Role of Ubiquitination in Transcriptional Regulation|Role of Ubiquitination in Cell Cycle Control and Programmed Cell DeathIntroduction|Discovery of the Ubiquitin Conjugation System|Protein Degradation in Trafficking Membranes I: Endoplasmic Reticulum Associated Degradation (ERAD) Pathway|Protein Degradation in Trafficking Membranes II: Endocytosis and lysosomal Degradation|Role of Ubiquitination in Transcriptional Regulation|Role of Ubiquitination in Cell Cycle Control and Programmed Cell Death
Ubiquitin-like Proteins|Functions of the Ubiquitin-Proteasome System in the Immune System|Ubiquitin and Cancer|Ubiquitin and Neurodegenerative Diseases: Alzheimer's and Parkinson's Diseases|More Diseases Involving Ubiquitin: Huntington's and Von Hippel-Lindau Disease|Too Much Degradation Can Be as Bad as Not Enough: Cystic Fibrosis and Liddle's SyndromeUbiquitin-like Proteins|Functions of the Ubiquitin-Proteasome System in the Immune System|Ubiquitin and Cancer|Ubiquitin and Neurodegenerative Diseases: Alzheimer's and Parkinson's Diseases|More Diseases Involving Ubiquitin: Huntington's and Von Hippel-Lindau Disease|Too Much Degradation Can Be as Bad as Not Enough: Cystic Fibrosis and Liddle's Syndrome
Potential Therapeutic Strategies in Ubiquitin-Related Diseases|||||Potential Therapeutic Strategies in Ubiquitin-Related Diseases|||||
{table}{table}
h3 Under the Radar Screen: How Bugs Trick Our Immune Defensesh3 Under the Radar Screen: How Bugs Trick Our Immune Defenses
(http://ocw.mit.edu/OcwWeb/Biology/7-340Spring-2007/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Biology/7-340Spring-2007/CourseHome/index.htm)
__Course Description__:__Course Description__:
In this course, we will explore the specific ways by which microbes defeat our immune system and the molecular mechanisms that are under attack (phagocytosis, the ubiquitin/proteasome pathway, MHC I/II antigen presentation). Through our discussion and dissection of the primary research literature, we will explore aspects of host-pathogen interactions. We will particularly emphasize the experimental techniques used in the field and how to read and understand research data. Technological advances in the fight against microbes will also be discussed, with specific examples.In this course, we will explore the specific ways by which microbes defeat our immune system and the molecular mechanisms that are under attack (phagocytosis, the ubiquitin/proteasome pathway, MHC I/II antigen presentation). Through our discussion and dissection of the primary research literature, we will explore aspects of host-pathogen interactions. We will particularly emphasize the experimental techniques used in the field and how to read and understand research data. Technological advances in the fight against microbes will also be discussed, with specific examples.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Biology/7-340Spring-2007/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Biology/7-340Spring-2007/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Phagocytosis|Toll-like receptors (TLRs)|The proteasome and ubiquitin|Major histocompatibility (MHC) class I antigen presentation|Major histocompatiblity (MHC) class II antigen presentation|CytokinesPhagocytosis|Toll-like receptors (TLRs)|The proteasome and ubiquitin|Major histocompatibility (MHC) class I antigen presentation|Major histocompatiblity (MHC) class II antigen presentation|Cytokines
Programmed cell death|Molecular mimicry|Antimicrobial peptides: Innate immunity effectors|||Programmed cell death|Molecular mimicry|Antimicrobial peptides: Innate immunity effectors|||
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h3 The Radical Consequences of Respiration: Reactive Oxygen Species in Aging and Diseaseh3 The Radical Consequences of Respiration: Reactive Oxygen Species in Aging and Disease
(http://ocw.mit.edu/OcwWeb/Biology/7-343Fall-2007/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Biology/7-343Fall-2007/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course will start with a survey of basic oxygen radical biochemistry followed by a discussion of the mechanisms of action of cellular as well as dietary antioxidants. After considering the normal physiological roles of oxidants, we will examine the effects of elevated ROS and a failure of cellular redox capacity on the rate of organismal and cellular aging as well as on the onset and progression of several major diseases that are often age-related. Topics will include ROS-induced effects on stem cell regeneration, insulin resistance, heart disease, neurodegenerative disorders, and cancer. The role of antioxidants in potential therapeutic strategies for modulating ROS levels will also be discussed.This course will start with a survey of basic oxygen radical biochemistry followed by a discussion of the mechanisms of action of cellular as well as dietary antioxidants. After considering the normal physiological roles of oxidants, we will examine the effects of elevated ROS and a failure of cellular redox capacity on the rate of organismal and cellular aging as well as on the onset and progression of several major diseases that are often age-related. Topics will include ROS-induced effects on stem cell regeneration, insulin resistance, heart disease, neurodegenerative disorders, and cancer. The role of antioxidants in potential therapeutic strategies for modulating ROS levels will also be discussed.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Biology/7-343Fall-2007/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Biology/7-343Fall-2007/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Introduction and background|The high price of energy: Mitrochondrial production of ROS|Radical messengers: ROS as facilitators of cellular signaling|Hired assassins: ROS in anti-pathogen defense|Antioxidants: fighting the good fightThe free radical theory: ROS and agingIntroduction and background|The high price of energy: Mitrochondrial production of ROS|Radical messengers: ROS as facilitators of cellular signaling|Hired assassins: ROS in anti-pathogen defense|Antioxidants: fighting the good fightThe free radical theory: ROS and aging
The root of the problem: oxidative damage in stem cell renewal|Balancing act: ROS effects on insulin resistance and diabetes|Breaking hearts: ROS in ischemic reperfusion injury|Brain drain: oxidative stress in neurodegenerative diseases|Foot-soldiers of renegade cells: ROS in cancer and oncogenic transformation|Fighting fire with fire: more ROS or less ROS as therapeutic strategies?The root of the problem: oxidative damage in stem cell renewal|Balancing act: ROS effects on insulin resistance and diabetes|Breaking hearts: ROS in ischemic reperfusion injury|Brain drain: oxidative stress in neurodegenerative diseases|Foot-soldiers of renegade cells: ROS in cancer and oncogenic transformation|Fighting fire with fire: more ROS or less ROS as therapeutic strategies?
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h3 Protein Folding Problemh3 Protein Folding Problem
(http://ocw.mit.edu/OcwWeb/Biology/7-88JFall-2007/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Biology/7-88JFall-2007/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects.This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Biology/7-88JFall-2007/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Biology/7-88JFall-2007/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Introduction to the problem|Side-chain review + Sulfur redox chemistry|The Anfinsen experiments|Globular protein structure + Protein interiors|Using the Protein database (PDB)|Helix-helix packing in globular proteinsIntroduction to the problem|Side-chain review + Sulfur redox chemistry|The Anfinsen experiments|Globular protein structure + Protein interiors|Using the Protein database (PDB)|Helix-helix packing in globular proteins
Beta-sheets + Beta-sheet packing|Experimental techniques: circular dichroism|Thermal denaturation + Coiled coils + Refolding of tropomyosin|Fluorescence spectroscopy|S-peptide helical folding|Detecting partially folded intermediatesBeta-sheets + Beta-sheet packing|Experimental techniques: circular dichroism|Thermal denaturation + Coiled coils + Refolding of tropomyosin|Fluorescence spectroscopy|S-peptide helical folding|Detecting partially folded intermediates
Prolyl isomerization|Cytochrome c refolding pathway|2-D NMR techniques|Collagen structure and folding in vivo|Procollagen folding in vitro|Protein calorimetry: BPTIProlyl isomerization|Cytochrome c refolding pathway|2-D NMR techniques|Collagen structure and folding in vivo|Procollagen folding in vitro|Protein calorimetry: BPTI
Protein misfolding and aggregation|Ribosome channel + Nascent chains + Trigger factor|Scaffolding proteins in viral shell assembly|Amyloid fiber formation in neuro degenerative disease|Chaperonin assisted foldingProtein misfolding and aggregation|Ribosome channel + Nascent chains + Trigger factor|Scaffolding proteins in viral shell assembly|Amyloid fiber formation in neuro degenerative disease|Chaperonin assisted folding
Eukariotic chaperonins|Paper topic discussion and choices|Membrane protein (rhodopsin) folding and assembly|Prion diseases|Etiology of some human protein deposition diseases|Eukariotic chaperonins|Paper topic discussion and choices|Membrane protein (rhodopsin) folding and assembly|Prion diseases|Etiology of some human protein deposition diseases|
{table}{table}
h2 Brain and Cognitive Sciencesh2 Brain and Cognitive Sciences
h3 Neuroscience and Behaviorh3 Neuroscience and Behavior
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-01Fall-2003/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-01Fall-2003/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course covers the relation of structure and function at various levels of neuronal integration. Topics include functional neuroanatomy and neurophysiology, sensory and motor systems, centrally programmed behavior, sensory systems, sleep and dreaming, motivation and reward, emotional displays of various types, "higher functions" and the neocortex, and neural processes in learning and memory. This course covers the relation of structure and function at various levels of neuronal integration. Topics include functional neuroanatomy and neurophysiology, sensory and motor systems, centrally programmed behavior, sensory systems, sleep and dreaming, motivation and reward, emotional displays of various types, "higher functions" and the neocortex, and neural processes in learning and memory.
__Audio Lectures__:__Audio Lectures__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-01Fall-2003/AudioLectures/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-01Fall-2003/AudioLectures/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Introduction to Brain-behavior Studies|History and Goals, II|History and Goals, III|History and Goals, IV|Cellular Mechanisms|Neuronal Conduction and TransmissionIntroduction to Brain-behavior Studies|History and Goals, II|History and Goals, III|History and Goals, IV|Cellular Mechanisms|Neuronal Conduction and Transmission
Synapses + Neuroanatomical Techniques|Introduction to CNS and its Evolution|Evolution (cont.) + Reflex and Cerebellar Channels|Brain Subdivisions + Channels of Conduction|Transection Effects + Neocortex|Spinal Cord + Autonomic NSSynapses + Neuroanatomical Techniques|Introduction to CNS and its Evolution|Evolution (cont.) + Reflex and Cerebellar Channels|Brain Subdivisions + Channels of Conduction|Transection Effects + Neocortex|Spinal Cord + Autonomic NS
Hindbrain and Midbrain|Midbrain and Forebrain|Development of CNS, Introduction|Cell migration + Axon Growth Stages|Influences on Axon Growth|Axonal Sprouting and RegenerationHindbrain and Midbrain|Midbrain and Forebrain|Development of CNS, Introduction|Cell migration + Axon Growth Stages|Influences on Axon Growth|Axonal Sprouting and Regeneration
Motor System, 1|Motor System, 2|Motor System, 3|Motor 4: Rythmic Outputs|Rhythms of Activity + Sleep and Waking|Sleep and Waking (cont.)Motor System, 1|Motor System, 2|Motor System, 3|Motor 4: Rythmic Outputs|Rhythms of Activity + Sleep and Waking|Sleep and Waking (cont.)
Habituation, Novelty Responses|Visual System 1: Anatomy, Ablations|Visual System 2: Physiology (orig: Ablation Effects)|Visual System 3: Ablation Studies|Visual System 4: Ablations (cont.) (Orig: Electrophysiology)|Visual System ConclusionHabituation, Novelty Responses|Visual System 1: Anatomy, Ablations|Visual System 2: Physiology (orig: Ablation Effects)|Visual System 3: Ablation Studies|Visual System 4: Ablations (cont.) (Orig: Electrophysiology)|Visual System Conclusion
Auditory System|Pain and Central Gray Area|Hypothalamus and Feeding|Drive, Reward + Agonistic Behavior|Higher Functions + Human Nature|Human Nature and NeuroscienceAuditory System|Pain and Central Gray Area|Hypothalamus and Feeding|Drive, Reward + Agonistic Behavior|Higher Functions + Human Nature|Human Nature and Neuroscience
{table}{table}
h3 Neural Basis of Learning and Memoryh3 Neural Basis of Learning and Memory
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-03Fall-2007/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-03Fall-2007/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course highlights the interplay between cellular and molecular storage mechanisms and the cognitive neuroscience of memory, with an emphasis on human and animal models of hippocampal mechanisms and function. This course highlights the interplay between cellular and molecular storage mechanisms and the cognitive neuroscience of memory, with an emphasis on human and animal models of hippocampal mechanisms and function.
__Selected Lectures Notes__:__Selected Lectures Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-03Fall-2007/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-03Fall-2007/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Lecture 1: Brief History of Work in the Area of Learning and Memory|Lecture 2: Introduction; Cells and Synapses|Lecture 3: Neuroimaging Techniques|Lecture 4: Skill Memory|Lecture 6: Sensory, Short-Term, and Working Memory|Lecture 21: Observational Learning; Mirror NeuronsLecture 1: Brief History of Work in the Area of Learning and Memory|Lecture 2: Introduction; Cells and Synapses|Lecture 3: Neuroimaging Techniques|Lecture 4: Skill Memory|Lecture 6: Sensory, Short-Term, and Working Memory|Lecture 21: Observational Learning; Mirror Neurons
Lecture 23: Emotional Learning and Memory|||||Lecture 23: Emotional Learning and Memory|||||
{table}{table}
h3 Neural Basis of Vision and Auditionh3 Neural Basis of Vision and Audition
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-04Fall-2006/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-04Fall-2006/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course examines the neural bases of visual and auditory processing for perception and sensorimotor control, focusing on physiological and anatomical studies of the mammalian nervous system as well as behavioral studies of animals and humans. Visual pattern, color and depth perception, auditory responses and speech coding, and spatial localization are studied.This course examines the neural bases of visual and auditory processing for perception and sensorimotor control, focusing on physiological and anatomical studies of the mammalian nervous system as well as behavioral studies of animals and humans. Visual pattern, color and depth perception, auditory responses and speech coding, and spatial localization are studied.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-04Fall-2006/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-04Fall-2006/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
The layout of the visual system, the retina, and the lateral geniculate nucleus|The visual cortex|The ON and OFF channels|The midget and parasol channels|Adaptation and color|Depth perceptionThe layout of the visual system, the retina, and the lateral geniculate nucleus|The visual cortex|The ON and OFF channels|The midget and parasol channels|Adaptation and color|Depth perception
Form perception|Illusions and visual prosthetics|The neural control of visually guided eye movements, subcortical control|The neural control of visually guided eye movements, cortical control|Motion perception and pursuit eye movements|Hair cells: Transduction, electrophysiology and "Cochlear Amplifier"Form perception|Illusions and visual prosthetics|The neural control of visually guided eye movements, subcortical control|The neural control of visually guided eye movements, cortical control|Motion perception and pursuit eye movements|Hair cells: Transduction, electrophysiology and "Cochlear Amplifier"
Auditory nerve; psychophysics of frequency resolution|Hearing loss and cochlear implants|Cochlear nucleus: Tonotopy, unit types and cell types|Brainstem reflexes: OC efferents and middle ear muscles|Sound localization I: Psychophysics and neural circuits|Sound localization II: Superior olivary complex and inferior colliculusAuditory nerve; psychophysics of frequency resolution|Hearing loss and cochlear implants|Cochlear nucleus: Tonotopy, unit types and cell types|Brainstem reflexes: OC efferents and middle ear muscles|Sound localization I: Psychophysics and neural circuits|Sound localization II: Superior olivary complex and inferior colliculus
Auditory cortex I: General physiology and role in sound localization|Auditory cortex II: Language; Bats and echolocation|Eaton-Peabody lab tour at Massachusetts Eye and Ear Infirmary|Comparison of vision and audition, vision review||Auditory cortex I: General physiology and role in sound localization|Auditory cortex II: Language; Bats and echolocation|Eaton-Peabody lab tour at Massachusetts Eye and Ear Infirmary|Comparison of vision and audition, vision review||
{table}{table}
h3 Brain Mechanisms for Hearing and Speechh3 Brain Mechanisms for Hearing and Speech
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-722JFall-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-722JFall-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
An advanced course covering anatomical, physiological, behavioral, and computational studies of the central nervous system relevant to speech and hearing. Students learn primarily by discussions of scientific papers on topics of current interest. Recent topics include cell types and neural circuits in the auditory brainstem, organization and processing in the auditory cortex, auditory reflexes and descending systems, functional imaging of the human auditory system, quantitative methods for relating neural responses to behavior, speech motor control, cortical representation of language, and auditory learning in songbirds.An advanced course covering anatomical, physiological, behavioral, and computational studies of the central nervous system relevant to speech and hearing. Students learn primarily by discussions of scientific papers on topics of current interest. Recent topics include cell types and neural circuits in the auditory brainstem, organization and processing in the auditory cortex, auditory reflexes and descending systems, functional imaging of the human auditory system, quantitative methods for relating neural responses to behavior, speech motor control, cortical representation of language, and auditory learning in songbirds.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-722JFall-2005/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-722JFall-2005/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Dorsal Cochlear Nucleus|Descending Systems|Cell Types and Circuits|Quantitative Methods|Thalamus and Cortex|NeuroimagingDorsal Cochlear Nucleus|Descending Systems|Cell Types and Circuits|Quantitative Methods|Thalamus and Cortex|Neuroimaging
Speech Motor Control|Motor Control|Cortical Language Processing|||Speech Motor Control|Motor Control|Cortical Language Processing|||
{table}{table}
h3 Statistical Methods in Brain and Cognitive Scienceh3 Statistical Methods in Brain and Cognitive Science
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-07Spring-2004/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-07Spring-2004/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course emphasizes statistics as a powerful tool for studying complex issues in behavioral and biological sciences, and explores the limitations of statistics as a method of inquiry. The course covers descriptive statistics, probability and random variables, inferential statistics, and basic issues in experimental design. Techniques introduced include confidence intervals, t-tests, F-tests, regression, and analysis of variance. Assignments include a project in data analysis.This course emphasizes statistics as a powerful tool for studying complex issues in behavioral and biological sciences, and explores the limitations of statistics as a method of inquiry. The course covers descriptive statistics, probability and random variables, inferential statistics, and basic issues in experimental design. Techniques introduced include confidence intervals, t-tests, F-tests, regression, and analysis of variance. Assignments include a project in data analysis.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-07Spring-2004/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-07Spring-2004/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Introduction to Statistics|Describing Data + Graphs, Central Tendency, and Spread|Probability, I|Probability, I (cont.) + Probability, II|Random Variables|Sampling TheoryIntroduction to Statistics|Describing Data + Graphs, Central Tendency, and Spread|Probability, I|Probability, I (cont.) + Probability, II|Random Variables|Sampling Theory
Confidence Intervals|Single-sample Hypothesis Testing, I|Single-sample Hypothesis Testing, II|Two-sample Hypothesis Testing, I|Two Sample t-Test|Two-sample Hypothesis Testing, IIConfidence Intervals|Single-sample Hypothesis Testing, I|Single-sample Hypothesis Testing, II|Two-sample Hypothesis Testing, I|Two Sample t-Test|Two-sample Hypothesis Testing, II
Experimental Design, I|Experimental Design, II|Experimental Design, II (cont.) + Regression and Correlation, I|Regression and Correlation, II|Regression and Correlation, III|Chi-square TestsExperimental Design, I|Experimental Design, II|Experimental Design, II (cont.) + Regression and Correlation, I|Regression and Correlation, II|Regression and Correlation, III|Chi-square Tests
One-way ANOVA, I|One-way ANOVA, II|Two-way ANOVA, I|Two-way ANOVA, II||One-way ANOVA, I|One-way ANOVA, II|Two-way ANOVA, I|Two-way ANOVA, II||
{table}{table}
h3 Human Memory and Learningh3 Human Memory and Learning
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-081Human-Memory-and-LearningFall2002/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-081Human-Memory-and-LearningFall2002/CourseHome/index.htm)
__Course Description__:__Course Description__:
Surveys the literature on the cognitive and neural organization of human memory and learning. Includes consideration of working memory and executive control, episodic and semantic memory, and implicit forms of memory. Emphasizes integration of cognitive theory with recent insights from functional neuroimaging (e.g., fMRI and PET).Surveys the literature on the cognitive and neural organization of human memory and learning. Includes consideration of working memory and executive control, episodic and semantic memory, and implicit forms of memory. Emphasizes integration of cognitive theory with recent insights from functional neuroimaging (e.g., fMRI and PET).
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-081Human-Memory-and-LearningFall2002/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-081Human-Memory-and-LearningFall2002/LectureNotes/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Lecture 1: What is Memory?|Lecture 3: Neuroimaging and Cognitive Control|Lecture 5: Episodic and PrimarycMemory|Lecture 9: Nondeclarative Memory||Lecture 1: What is Memory?|Lecture 3: Neuroimaging and Cognitive Control|Lecture 5: Episodic and PrimarycMemory|Lecture 9: Nondeclarative Memory||
{table}{table}
h3 Brain Structure and its Originsh3 Brain Structure and its Origins
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-14Spring-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-14Spring-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course covers major CNS structures with emphasis on systems being used as models for experimental studies of development and plasticity. Topics include basic patterns of connections in CNS, embryogenesis, PNS anatomy and development, process outgrowth and synaptogenesis, growth factors and cell survival, spinal and hindbrain anatomy, and development of regional specificity with an introduction to comparative anatomy and CNS evolution. A review of lab techniques (anatomy, tissue culture) is also covered as well as the trigeminal system, retinotectal system development, plasticity, regeneration, neocortex anatomy and development, the olfactory system, corpus striatum, brain transplants, the limbic system and hippocampal anatomy and plasticity.This course covers major CNS structures with emphasis on systems being used as models for experimental studies of development and plasticity. Topics include basic patterns of connections in CNS, embryogenesis, PNS anatomy and development, process outgrowth and synaptogenesis, growth factors and cell survival, spinal and hindbrain anatomy, and development of regional specificity with an introduction to comparative anatomy and CNS evolution. A review of lab techniques (anatomy, tissue culture) is also covered as well as the trigeminal system, retinotectal system development, plasticity, regeneration, neocortex anatomy and development, the olfactory system, corpus striatum, brain transplants, the limbic system and hippocampal anatomy and plasticity.
__Audio Lectures__:__Audio Lectures__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-14Spring-2005/AudioLectures/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-14Spring-2005/AudioLectures/index.htm)
{table} {table}
Column1 | Column2 | Column3 | Column4 | Column5 | Column6Column1 | Column2 | Column3 | Column4 | Column5 | Column6
Introduction: Brain Orientation, Primitive Cellular Activities|Introduction: Methods; Primitive Cellular Activities|Steps to the CNS of Chordates|Steps to the CNS of Chordates (cont.)|Specializations in CNS Evolution|Specializations in CNS Evolution (cont.)Introduction: Brain Orientation, Primitive Cellular Activities|Introduction: Methods; Primitive Cellular Activities|Steps to the CNS of Chordates|Steps to the CNS of Chordates (cont.)|Specializations in CNS Evolution|Specializations in CNS Evolution (cont.)
Spinal Cord Development and Anatomy|Spinal Cord Development and Anatomy (cont.)|Differentiation of the Brain Vesicles|Differentiation of the Brain Vesicles (cont.)|Differentiation of the Brain Vesicles (cont.)|Differentiation of the Brain Vesicles (cont.)Spinal Cord Development and Anatomy|Spinal Cord Development and Anatomy (cont.)|Differentiation of the Brain Vesicles|Differentiation of the Brain Vesicles (cont.)|Differentiation of the Brain Vesicles (cont.)|Differentiation of the Brain Vesicles (cont.)
Axon Growth|Axon Growth (cont.)|Motor Systems|Motor Systems (cont.)|Taste and Olfactory Systems|Taste and Olfactory Systems (cont.)Axon Growth|Axon Growth (cont.)|Motor Systems|Motor Systems (cont.)|Taste and Olfactory Systems|Taste and Olfactory Systems (cont.)
Visual Systems|Visual Systems (cont.)|Visual Systems (cont.)|Auditory Systems|Auditory Systems (cont.)|Forebrain IntroductionVisual Systems|Visual Systems (cont.)|Visual Systems (cont.)|Auditory Systems|Auditory Systems (cont.)|Forebrain Introduction
Hypothalamus; Limbic System|Hypothalamus; Limbic System (cont.)|Hypothalamus; Limbic System (cont.)|Hypothalamus; Limbic System (cont.)|Hypothalamus; Limbic System (cont.)|Corpus StriatumHypothalamus; Limbic System|Hypothalamus; Limbic System (cont.)|Hypothalamus; Limbic System (cont.)|Hypothalamus; Limbic System (cont.)|Hypothalamus; Limbic System (cont.)|Corpus Striatum
Corpus Striatum (cont.)|Neocortex|Neocortex (cont.)|Neocortex (cont.)|Neocortex (cont.)|Plastic Systems: Cerebellum, Striatum, CortexCorpus Striatum (cont.)|Neocortex|Neocortex (cont.)|Neocortex (cont.)|Neocortex (cont.)|Plastic Systems: Cerebellum, Striatum, Cortex
{table}{table}
h3 Animal Behaviorh3 Animal Behavior
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-20Fall-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-20Fall-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
Most of the major categories of adaptive behavior can be seen in all animals. This course begins with the evolution of behavior, the driver of nervous system evolution, reviewed using concepts developed in ethology, sociobiology, other comparative studies, and in studies of brain evolution. The roles of various types of plasticity are considered, as well as foraging and feeding, defensive and aggressive behavior, courtship and reproduction, migration and navigation, social activities and communication, with contributions of inherited patterns and cognitive abilities. Both field and laboratory based studies are reviewed; and finally, human behavior is considered within the context of primate studies.Most of the major categories of adaptive behavior can be seen in all animals. This course begins with the evolution of behavior, the driver of nervous system evolution, reviewed using concepts developed in ethology, sociobiology, other comparative studies, and in studies of brain evolution. The roles of various types of plasticity are considered, as well as foraging and feeding, defensive and aggressive behavior, courtship and reproduction, migration and navigation, social activities and communication, with contributions of inherited patterns and cognitive abilities. Both field and laboratory based studies are reviewed; and finally, human behavior is considered within the context of primate studies.
__Audio Lectures__:__Audio Lectures__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-20Fall-2005/AudioLectures/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-20Fall-2005/AudioLectures/index.htm)
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Animals in Human History + Amateur and Professional Studies|Introduction to Ethology + Tinbergen's Four Questions + Field Studies of Birds|Lorenz' Jackdaws|Ethology of Geese + Fixed Action Patterns and the Central Nervous System|Input and Output Sides of Innate Behavior + MotivationAnimals in Human History + Amateur and Professional Studies|Introduction to Ethology + Tinbergen's Four Questions + Field Studies of Birds|Lorenz' Jackdaws|Ethology of Geese + Fixed Action Patterns and the Central Nervous System|Input and Output Sides of Innate Behavior + Motivation
Motivation (cont.)|Lorenz on Fixed Action Patterns|Lorenz on Innate Releasing Mechanisms|Models, Hierarchies and Chains of Action Patterns|Spatial Orientation + Multiple Motivations|Evolution of Behavior, Genes, LearningMotivation (cont.)|Lorenz on Fixed Action Patterns|Lorenz on Innate Releasing Mechanisms|Models, Hierarchies and Chains of Action Patterns|Spatial Orientation + Multiple Motivations|Evolution of Behavior, Genes, Learning
Navigation, Migration, Communication|Communication (cont.)|Foraging|Anti-predator Behavior|Anti-predator Behavior (cont.)|Mating and Reproduction, IntroductionNavigation, Migration, Communication|Communication (cont.)|Foraging|Anti-predator Behavior|Anti-predator Behavior (cont.)|Mating and Reproduction, Introduction
Sociobiology Introduction|Sociobiology Subject Matter|Genes and Behaviors|Sociobiology and Science|Discoveries of Sociobiology|Cultural Determinism and SociobiologySociobiology Introduction|Sociobiology Subject Matter|Genes and Behaviors|Sociobiology and Science|Discoveries of Sociobiology|Cultural Determinism and Sociobiology
Sociobiology and Culture|Practical Issues in Study of Adaptation|The Triumph of Sociobiology|||Sociobiology and Culture|Practical Issues in Study of Adaptation|The Triumph of Sociobiology|||
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h3 Neural Coding and Perception of Soundh3 Neural Coding and Perception of Sound
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-723Spring-2005/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-723Spring-2005/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course focuses on neural structures and mechanisms mediating the detection, localization and recognition of sounds. Discussions cover how acoustic signals are coded by auditory neurons, the impact of these codes on behavioral performance, and the circuitry and cellular mechanisms underlying signal transformations. Topics include temporal coding, neural maps and feature detectors, learning and plasticity, and feedback control. General principles are conveyed by theme discussions of auditory masking, sound localization, musical pitch, speech coding, and cochlear implants.This course focuses on neural structures and mechanisms mediating the detection, localization and recognition of sounds. Discussions cover how acoustic signals are coded by auditory neurons, the impact of these codes on behavioral performance, and the circuitry and cellular mechanisms underlying signal transformations. Topics include temporal coding, neural maps and feature detectors, learning and plasticity, and feedback control. General principles are conveyed by theme discussions of auditory masking, sound localization, musical pitch, speech coding, and cochlear implants.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-723Spring-2005/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Health-Sciences-and-Technology/HST-723Spring-2005/LectureNotes/index.htm)
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Hearing and the Auditory System: An Overview|||||Hearing and the Auditory System: An Overview|||||
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__Theme 1: Masking and Frequency Selectivity____Theme 1: Masking and Frequency Selectivity__
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How the Ear Works (Functional Cochlear Mechanics)|Stimulus Coding in the Auditory Nerve|Masking and Frequency Selectivity|Masking and Nonlinearity|Masking and Nonlinearity (cont.)|Cochlear ImplantsHow the Ear Works (Functional Cochlear Mechanics)|Stimulus Coding in the Auditory Nerve|Masking and Frequency Selectivity|Masking and Nonlinearity|Masking and Nonlinearity (cont.)|Cochlear Implants
Intensity Perception and Cochlear Hearing Loss|||||Intensity Perception and Cochlear Hearing Loss|||||
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__Theme 2: Cellular Mechanisms in the Cochlear Nucleus____Theme 2: Cellular Mechanisms in the Cochlear Nucleus__
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Channels, Synapses and Neurotransmitters|Cellular Mechanisms in the Cochlear Nucleus|Cellular Mechanisms in the Cochlear Nucleus|Cellular Mechanisms in the Cochlear Nucleus||Channels, Synapses and Neurotransmitters|Cellular Mechanisms in the Cochlear Nucleus|Cellular Mechanisms in the Cochlear Nucleus|Cellular Mechanisms in the Cochlear Nucleus||
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__Theme 3: Binaural Interactions____Theme 3: Binaural Interactions__
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Binaural Hearing|Binaural Interactions in the Auditory Brainstem|Binaural Interactions|Binaural Interactions||Binaural Hearing|Binaural Interactions in the Auditory Brainstem|Binaural Interactions|Binaural Interactions||
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__Theme 4: Pitch and Temporal Coding____Theme 4: Pitch and Temporal Coding__
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Pitch of Pure and Complex Tones|Neural Processing of Pitch|Pitch and Temporal Coding|Pitch and Temporal Coding (cont.)||Pitch of Pure and Complex Tones|Neural Processing of Pitch|Pitch and Temporal Coding|Pitch and Temporal Coding (cont.)||
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__Theme 5: Neural Maps and Plasticity____Theme 5: Neural Maps and Plasticity__
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Auditory Cortex: Cortical organization|The Human Auditory System|Neural Maps and Plasticity|Neural Maps and Plasticity (cont.)||Auditory Cortex: Cortical organization|The Human Auditory System|Neural Maps and Plasticity|Neural Maps and Plasticity (cont.)||
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__Theme 6: Auditory Scene Analysis and Object Formation____Theme 6: Auditory Scene Analysis and Object Formation__
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Auditory Scene Analysis (ASA) and Object Formation|Scene Analysis||||Auditory Scene Analysis (ASA) and Object Formation|Scene Analysis||||
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h3 Introduction to Computational Neuroscienceh3 Introduction to Computational Neuroscience
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-29JSpring-2004/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-29JSpring-2004/CourseHome/index.htm)
__Course Description__:__Course Description__:
This course gives a mathematical introduction to neural coding and dynamics. Topics include convolution, correlation, linear systems, game theory, signal detection theory, probability theory, information theory, and reinforcement learning. Applications to neural coding, focusing on the visual system are covered, as well as Hodgkin-Huxley and other related models of neural excitability, stochastic models of ion channels, cable theory, and models of synaptic transmission.This course gives a mathematical introduction to neural coding and dynamics. Topics include convolution, correlation, linear systems, game theory, signal detection theory, probability theory, information theory, and reinforcement learning. Applications to neural coding, focusing on the visual system are covered, as well as Hodgkin-Huxley and other related models of neural excitability, stochastic models of ion channels, cable theory, and models of synaptic transmission.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-29JSpring-2004/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-29JSpring-2004/LectureNotes/index.htm)
{table} {table}
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Examples of Neural Coding, Simple Linear Regression|Convolution and Correlation 1 + Firing Rate|Simple Statistics and Linear Regression|Convolution and Correlation 2 + Spike-triggered Average + Wiener-Hopf Equations and White Noise Analysis|Operant Matching 1|Examples of Neural Coding, Simple Linear Regression|Convolution and Correlation 1 + Firing Rate|Simple Statistics and Linear Regression|Convolution and Correlation 2 + Spike-triggered Average + Wiener-Hopf Equations and White Noise Analysis|Operant Matching 1|
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h3 Neural Plasticity in Learning and Developmenth3 Neural Plasticity in Learning and Development
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-301JNeural-Plasticity-in-Learning-and-DevelopmentSpring2002/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-301JNeural-Plasticity-in-Learning-and-DevelopmentSpring2002/CourseHome/index.htm)
__Course Description__:__Course Description__:
Roles of neural plasticity in learning and memory and in development of invertebrates and mammals. An in-depth critical analysis of current literature of molecular, cellular, genetic, electrophysiological, and behavioral studies. Discussion of original papers supplemented by introductory lectures.Roles of neural plasticity in learning and memory and in development of invertebrates and mammals. An in-depth critical analysis of current literature of molecular, cellular, genetic, electrophysiological, and behavioral studies. Discussion of original papers supplemented by introductory lectures.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-301JNeural-Plasticity-in-Learning-and-DevelopmentSpring2002/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-301JNeural-Plasticity-in-Learning-and-DevelopmentSpring2002/LectureNotes/index.htm)
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Lecture 1: Introduction|Lecture 2: Behavior and Plasticity|Lecture 3: Synaptic Transmission|Lecture 4: Potentiation of Synaptic Transmission|Lecture 5: Expression of Plasticity|Lecture 1: Introduction|Lecture 2: Behavior and Plasticity|Lecture 3: Synaptic Transmission|Lecture 4: Potentiation of Synaptic Transmission|Lecture 5: Expression of Plasticity|
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h3 Parkinson's Disease Workshoph3 Parkinson's Disease Workshop
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-458Summer-2006/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-458Summer-2006/CourseHome/index.htm)
__Course Description__:__Course Description__:
Parkinson's disease (PD) is a chronic, progressive, degenerative disease of the brain that produces movement disorders and deficits in executive functions, working memory, visuospatial functions, and internal control of attention. It is named after James Parkinson (1755-1824), the English neurologist who described the first case.Parkinson's disease (PD) is a chronic, progressive, degenerative disease of the brain that produces movement disorders and deficits in executive functions, working memory, visuospatial functions, and internal control of attention. It is named after James Parkinson (1755-1824), the English neurologist who described the first case.
This six-week summer workshop explored different aspects of PD, including clinical characteristics, structural neuroimaging, neuropathology, genetics, and cognitive function (mental status, cognitive control processes, working memory, and long-term declarative memory). The workshop did not take up the topics of motor control, nondeclarative memory, or treatment. This six-week summer workshop explored different aspects of PD, including clinical characteristics, structural neuroimaging, neuropathology, genetics, and cognitive function (mental status, cognitive control processes, working memory, and long-term declarative memory). The workshop did not take up the topics of motor control, nondeclarative memory, or treatment.
__Lecture Notes__:__Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-458Summer-2006/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-458Summer-2006/LectureNotes/index.htm)
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Cognition in Parkinson's Disease|Neuropathology and Structural Neuroimaging in Parkinson's Disease|Genetics of Parkinson's Disease|Cognitive Control Processes and Working Memory in Parkinson's Disease|A Systems Neuroscience Approach to Memory|Long-term Declarative Memory in Parkinson DiseaseCognition in Parkinson's Disease|Neuropathology and Structural Neuroimaging in Parkinson's Disease|Genetics of Parkinson's Disease|Cognitive Control Processes and Working Memory in Parkinson's Disease|A Systems Neuroscience Approach to Memory|Long-term Declarative Memory in Parkinson Disease
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h3 Scene Understanding Symposiumh3 Scene Understanding Symposium
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-459Spring-2006/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-459Spring-2006/CourseHome/index.htm)
__Course Description__:__Course Description__:
What are the circuits, mechanisms and representations that permit the recognition of a visual scene from just one glance? In this one-day seminar on Scene Understanding, speakers from a variety of disciplines - neurophysiology, cognitive neuroscience, visual cognition, computational neuroscience and computer vision - will address a range of topics related to scene recognition, including natural image categorization, contextual effects on object recognition, and the role of attention in scene understanding and visual art. The goal is to encourage exchanges between researchers of all fields of brain sciences in the burgeoning field of scene understanding.What are the circuits, mechanisms and representations that permit the recognition of a visual scene from just one glance? In this one-day seminar on Scene Understanding, speakers from a variety of disciplines - neurophysiology, cognitive neuroscience, visual cognition, computational neuroscience and computer vision - will address a range of topics related to scene recognition, including natural image categorization, contextual effects on object recognition, and the role of attention in scene understanding and visual art. The goal is to encourage exchanges between researchers of all fields of brain sciences in the burgeoning field of scene understanding.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-459Spring-2006/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-459Spring-2006/LectureNotes/index.htm)
{table} {table}
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From Zero to Gist in 200 msec: The Time Course of Scene Recognition|Feedforward Theories of Visual Cortex Predict Human Performance in Rapid Image Categorization|Latency, Duration and Codes for Objects in Inferior Temporal Cortex|From Feedforward Vision to Natural Vision: The Impact of Free Viewing, Task, and Clutter on Monkey Inferior Temporal Object Representations|Perception of Objects in Natural Scenes and the Role of Attention|Natural Scene Categorization: From Humans to ComputersFrom Zero to Gist in 200 msec: The Time Course of Scene Recognition|Feedforward Theories of Visual Cortex Predict Human Performance in Rapid Image Categorization|Latency, Duration and Codes for Objects in Inferior Temporal Cortex|From Feedforward Vision to Natural Vision: The Impact of Free Viewing, Task, and Clutter on Monkey Inferior Temporal Object Representations|Perception of Objects in Natural Scenes and the Role of Attention|Natural Scene Categorization: From Humans to Computers
Using the Forest to See the Trees: A Computational Model Relating Features, Objects and Scenes|Scene Perception after Those First Few Hundred Milliseconds||||Using the Forest to See the Trees: A Computational Model Relating Features, Objects and Scenes|Scene Perception after Those First Few Hundred Milliseconds||||
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h3 Statistical Learning Theory and Applicationsh3 Statistical Learning Theory and Applications
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-520Statistical-Learning-Theory-and-ApplicationsSpring2003/CourseHome/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-520Statistical-Learning-Theory-and-ApplicationsSpring2003/CourseHome/index.htm)
__Course Description__:__Course Description__:
Focuses on the problem of supervised learning from the perspective of modern statistical learning theory starting with the theory of multivariate function approximation from sparse data. Develops basic tools such as Regularization including Support Vector Machines for regression and classification. Derives generalization bounds using both stability and VC theory. Discusses topics such as boosting and feature selection. Examines applications in several areas: computer vision, computer graphics, text classification and bioinformatics.Focuses on the problem of supervised learning from the perspective of modern statistical learning theory starting with the theory of multivariate function approximation from sparse data. Develops basic tools such as Regularization including Support Vector Machines for regression and classification. Derives generalization bounds using both stability and VC theory. Discusses topics such as boosting and feature selection. Examines applications in several areas: computer vision, computer graphics, text classification and bioinformatics.
__Selected Lecture Notes__:__Selected Lecture Notes__:
(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-520Statistical-Learning-Theory-and-ApplicationsSpring2003/LectureNotes/index.htm)(http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-520Statistical-Learning-Theory-and-ApplicationsSpring2003/LectureNotes/index.htm)
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The Learning Problem in Perspective|Regularization and Reproducing Kernel Hilbert Spaces|Regression and Least-Squares Classification|Support Vector Machines for Classification|Generalization Bounds, Introduction to Stability|Stability of Tikhonov RegularizationThe Learning Problem in Perspective|Regularization and Reproducing Kernel Hilbert Spaces|Regression and Least-Squares Classification|Support Vector Machines for Classification|Generalization Bounds, Introduction to Stability|Stability of Tikhonov Regularization
Consistency and Uniform Convergence Over Function Classes|Necessary and Sufficient Conditions for Uniform Convergence|Bagging and Boosting|Computer Vision, Object Detection|Approximation Theory|RKHS, Mercer Thm, Unbounded Domains, Frames and WaveletsConsistency and Uniform Convergence Over Function Classes|Necessary and Sufficient Conditions for Uniform Convergence|Bagging and Boosting|Computer Vision, Object Detection|Approximation Theory|RKHS, Mercer Thm, Unbounded Domains, Frames and Wavelets
Bioinformatics|Text|Regularization Networks|Morphable Models for Video|Leave-one-out Approximations|Bayesian InterpretationsBioinformatics|Text|Regularization Networks|Morphable Models for Video|Leave-one-out Approximations|Bayesian Interpretations
Multiclass Classification|Math Camp 1: Functional Analysis|Math Camp 2: Lagrange Multipliers/Convex Optimization|SVM Rules of Thumb||Multiclass Classification|Math Camp 1: Functional Analysis|Math Camp 2: Lagrange Multipliers/Convex Optimization|SVM Rules of Thumb||
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 h3 Language Processing
 (http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-591JFall-2004/CourseHome/index.htm)
 
 __Course Description__:
 This course is a seminar in real-time language comprehension. It considers models of sentence and discourse comprehension from the linguistic, psychology, and artificial intelligence literature, including symbolic and connectionist models. Topics include ambiguity resolution and linguistic complexity; the use of lexical, syntactic, semantic, pragmatic, contextual and prosodic information in language comprehension; the relationship between the computational resources available in working memory and the language processing mechanism; and the psychological reality of linguistic representations.
 
 __Selected Lecture Notes__:
 (http://ocw.mit.edu/OcwWeb/Brain-and-Cognitive-Sciences/9-591JFall-2004/LectureNotes/index.htm)
 
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 Course Overview + Modularity in Sentence Comprehension|Resources and Sentence Complexity + The Complexity of Unambiguous Sentences + The Dependency Locality Theory|Working Memory and Sentence Comprehension|Resources and Ambiguity Resolution + The Serial / Parallel Question|Experience / Frequency and Ambiguity Resolution|Symbolic Computational Approaches to Language Parsing + Parsing Strategies + Shift-reduce Parsing
 Referential and Contextual Issues in Sentence Comprehension|Event-related Potentials (ERPs) and Other Brain-imaging Methods Investigating Sentence Comprehension||||
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