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| h1 Courses of Interest: | h1 Courses of Interest: |
| (http://ocw.mit.edu/OcwWeb/web/courses/courses/index.htm#top) | (http://ocw.mit.edu/OcwWeb/web/courses/courses/index.htm#top) |
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| h2 Biological Engineering | h2 Biological Engineering |
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| h3 Macroepidemiology | h3 Macroepidemiology |
| (http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-102Spring-2005/CourseHome/index.htm) | (http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-102Spring-2005/CourseHome/index.htm) |
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| __Course Description__: | __Course Description__: |
| This course presents a challenging multi-dimensional perspective on the causes of human disease and mortality. The course focuses on analyses of major causes of mortality in the US since 1900: cancer, cardiovascular and cerebrovascular diseases, diabetes, and infectious diseases. | This course presents a challenging multi-dimensional perspective on the causes of human disease and mortality. The course focuses on analyses of major causes of mortality in the US since 1900: cancer, cardiovascular and cerebrovascular diseases, diabetes, and infectious diseases. |
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| h3 Chemicals in the Environment: Toxicology and Public Health | h3 Chemicals in the Environment: Toxicology and Public Health |
| (http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-104JSpring-2005/CourseHome/index.htm) | (http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-104JSpring-2005/CourseHome/index.htm) |
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| __Course Description__: | __Course Description__: |
| This course addresses the challenges of defining a relationship between exposure to environmental chemicals and human disease. Course topics include epidemiological approaches to understanding disease causation; biostatistical methods; evaluation of human exposure to chemicals, and their internal distribution, metabolism, reactions with cellular components, and biological effects; and qualitative and quantitative health risk assessment methods used in the U.S. as bases for regulatory decision-making. | This course addresses the challenges of defining a relationship between exposure to environmental chemicals and human disease. Course topics include epidemiological approaches to understanding disease causation; biostatistical methods; evaluation of human exposure to chemicals, and their internal distribution, metabolism, reactions with cellular components, and biological effects; and qualitative and quantitative health risk assessment methods used in the U.S. as bases for regulatory decision-making. |
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| __Selected Lecture Notes__: | __Selected Lecture Notes__: |
| (http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-104JSpring-2005/LectureNotes/index.htm) | (http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-104JSpring-2005/LectureNotes/index.htm) |
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| {table} | {table} |
| Column1 | Column2 | Column3 | Column4 | Column5 | Column6 | Column1 | Column2 | Column3 | Column4 | Column5 | Column6 |
| Introductory Lecture|Watch film A Civil Action|From the Real World to Hollywood and Back Again|Epidemiology: Persons, Places, and Time|Epidemiology: Test Development and Relative Risk|Biostatistics: Concepts in Variance | Introductory Lecture|Watch film A Civil Action|From the Real World to Hollywood and Back Again|Epidemiology: Persons, Places, and Time|Epidemiology: Test Development and Relative Risk|Biostatistics: Concepts in Variance |
| Biostatistics: Distribution and the Mean|Confidence Intervals|Biostatistics: Detecting Differences and Correlations|Biostatistics: Poisson Analyses and Power|Environetics: Cause and Effect|Environetics: Study Design - Retrospective versus Prospective | Biostatistics: Distribution and the Mean|Confidence Intervals|Biostatistics: Detecting Differences and Correlations|Biostatistics: Poisson Analyses and Power|Environetics: Cause and Effect|Environetics: Study Design - Retrospective versus Prospective |
| Environetics: Putting it all together - Evaluating Studies|Evaluating Environmental Causes of Mesothelioma|Quantitative Risk Assessment 1|Quantitative Risk Assessment 2|Toxicology 1|Toxicology 2 | Environetics: Putting it all together - Evaluating Studies|Evaluating Environmental Causes of Mesothelioma|Quantitative Risk Assessment 1|Quantitative Risk Assessment 2|Toxicology 1|Toxicology 2 |
| Toxicology 3|Toxicology 4|Toxicology 5|Quantitative Risk Assessment 3|Quantitative Risk Assessment 4| | Toxicology 3|Toxicology 4|Toxicology 5|Quantitative Risk Assessment 3|Quantitative Risk Assessment 4| |
| {table} | {table} |
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| h3 Systems Microbiology | h3 Systems Microbiology |
| (http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-106JFall-2006/CourseHome/index.htm) | (http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-106JFall-2006/CourseHome/index.htm) |
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| __Course Description__: | __Course Description__: |
| This course covers introductory microbiology from a systems perspective, considering microbial diversity, population dynamics, and genomics. Emphasis is placed on the delicate balance between microbes and humans, and the changes that result in the emergence of infectious diseases and antimicrobial resistance. The case study approach covers such topics as vaccines, toxins, biodefense, and infections including Legionnaire’s disease, tuberculosis, Helicobacter pylori, and plague. | This course covers introductory microbiology from a systems perspective, considering microbial diversity, population dynamics, and genomics. Emphasis is placed on the delicate balance between microbes and humans, and the changes that result in the emergence of infectious diseases and antimicrobial resistance. The case study approach covers such topics as vaccines, toxins, biodefense, and infections including Legionnaire’s disease, tuberculosis, Helicobacter pylori, and plague. |
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| __Lecture Notes__: | __Lecture Notes__: |
| (http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-106JFall-2006/LectureNotes/index.htm) | (http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-106JFall-2006/LectureNotes/index.htm) |
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| {table} | {table} |
| Column1 | Column2 | Column3 | Column4 | Column5 | Column6 | Column1 | Column2 | Column3 | Column4 | Column5 | Column6 |
| Early Earth/Microbial Evolution|Cell Structure/Function|Biological Energy Conservation|Microbial Growth|Metabolic Regulation|Virology | Early Earth/Microbial Evolution|Cell Structure/Function|Biological Energy Conservation|Microbial Growth|Metabolic Regulation|Virology |
| Information Flow in Biological Systems|Regulation of Cell Activity|Genetic Exchange in Bacteria|Experimental Evolution: Optimization of Metabolic Systems|Genomics I|Genomics II | Information Flow in Biological Systems|Regulation of Cell Activity|Genetic Exchange in Bacteria|Experimental Evolution: Optimization of Metabolic Systems|Genomics I|Genomics II |
| Metabolic Diversity I|Metabolic Diversity II|Microbial Ecology|Microbial Growth Control|Microbe-host Interactions|Immunology I | Metabolic Diversity I|Metabolic Diversity II|Microbial Ecology|Microbial Growth Control|Microbe-host Interactions|Immunology I |
| Immunology II|Diagnostic Microbiology|Person-to-person Transmission|Epidemiology|Animal- and Arthropod-transmitted Diseases|Review | Immunology II|Diagnostic Microbiology|Person-to-person Transmission|Epidemiology|Animal- and Arthropod-transmitted Diseases|Review |
| {table} | {table} |
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| h3 Mechanisms of Drug Actions | h3 Mechanisms of Drug Actions |
| (http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-201Fall-2005/CourseHome/index.htm) | (http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-201Fall-2005/CourseHome/index.htm) |
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| __Course Description__: | __Course Description__: |
| This course covers the chemical and biological analysis of the metabolism and distribution of drugs, toxins and chemicals in animals and humans, and the mechanism by which they cause therapeutic and toxic responses. Metabolism and toxicity as a basis for drug development is also covered. | This course covers the chemical and biological analysis of the metabolism and distribution of drugs, toxins and chemicals in animals and humans, and the mechanism by which they cause therapeutic and toxic responses. Metabolism and toxicity as a basis for drug development is also covered. |
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| __Selected Lecture Notes__: | __Selected Lecture Notes__: |
| (http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-201Fall-2005/LectureNotes/index.htm) | (http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-201Fall-2005/LectureNotes/index.htm) |
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| {table} | {table} |
| Column1 | Column2 | Column3 | Column4 | Column5 | Column6 | Column1 | Column2 | Column3 | Column4 | Column5 | Column6 |
| Introduction and Principles|Chemistry/Biochemistry Review|Overview of Drug Development|Uptake/Transport/Distribution of Drugs|Drug Transporters|Bioethics Seminar | Introduction and Principles|Chemistry/Biochemistry Review|Overview of Drug Development|Uptake/Transport/Distribution of Drugs|Drug Transporters|Bioethics Seminar |
| Drug Transporters (cont.)|Introduction to Drug Metabolism|Liver Lecture|Drug Metabolism 2|Drug Metabolism 3|Drug Metabolism 4| | Drug Transporters (cont.)|Introduction to Drug Metabolism|Liver Lecture|Drug Metabolism 2|Drug Metabolism 3|Drug Metabolism 4| |
| Oxygen Radicals in Drug Toxicity|Drug Toxicities|Drug Toxicities (cont.)|Bioethics Seminar|Pharmacokinetics|Pharmacokinetics (cont.) | Oxygen Radicals in Drug Toxicity|Drug Toxicities|Drug Toxicities (cont.)|Bioethics Seminar|Pharmacokinetics|Pharmacokinetics (cont.) |
| Receptors and Case Study - Omeprazole|Case Study - Omeprazole|Case Study - Omeprazole (cont.)|Case Study - Acetaminophen|Case Study - Acetaminophen (cont.)|Case Study - Statins | Receptors and Case Study - Omeprazole|Case Study - Omeprazole|Case Study - Omeprazole (cont.)|Case Study - Acetaminophen|Case Study - Acetaminophen (cont.)|Case Study - Statins |
| Case Study - Statins (cont.)|Drug Industry Seminar|Case Study - Statins (cont.)||| | Case Study - Statins (cont.)|Drug Industry Seminar|Case Study - Statins (cont.)||| |
| {table} | {table} |
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| h3 Molecular and Cellular Pathophysiology | h3 Molecular and Cellular Pathophysiology |
| (http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-450Spring-2005/CourseHome/index.htm) | (http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-450Spring-2005/CourseHome/index.htm) |
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| __Course Description__: | __Course Description__: |
| This course focuses on the fundamentals of tissue and organ response to injury from a molecular and cellular perspective. There is a special emphasis on disease states that bridge infection, inflammation, immunity, and cancer. The systems approach to pathophysiology includes lectures, critical evaluation of recent scientific papers, and student projects and presentations. | This course focuses on the fundamentals of tissue and organ response to injury from a molecular and cellular perspective. There is a special emphasis on disease states that bridge infection, inflammation, immunity, and cancer. The systems approach to pathophysiology includes lectures, critical evaluation of recent scientific papers, and student projects and presentations. |
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| __Selected Lecture Notes__: | __Selected Lecture Notes__: |
| (http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-450Spring-2005/LectureNotes/index.htm) | (http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-450Spring-2005/LectureNotes/index.htm) |
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| {table} | {table} |
| Column1 | Column2 | Column3 | Column4 | Column5 | Column6 | Column1 | Column2 | Column3 | Column4 | Column5 | Column6 |
| Introduction to 20.450 and HCC|Cellular Pathology|Inflammation|Liver Anatomy and Histology|Immunity|Neoplasia | Introduction to 20.450 and HCC|Cellular Pathology|Inflammation|Liver Anatomy and Histology|Immunity|Neoplasia |
| Neoplasia (cont.)|Infectious Diseases|Liver and Biliary|Hepatocarcinogenesis|Animal Models|Special Topic | Neoplasia (cont.)|Infectious Diseases|Liver and Biliary|Hepatocarcinogenesis|Animal Models|Special Topic |
| {table} | {table} |
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| h3 Design of Medical Devices and Implants | h3 Design of Medical Devices and Implants |
| (http://ocw.mit.edu/OcwWeb/Mechanical-Engineering/2-782JSpring-2006/CourseHome/index.htm) | (http://ocw.mit.edu/OcwWeb/Mechanical-Engineering/2-782JSpring-2006/CourseHome/index.htm) |
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| __Course Description__: | __Course Description__: |
| This design course targets the solution of clinical problems by use of implants and other medical devices. Topics include the systematic use of cell-matrix control volumes; the role of stress analysis in the design process; anatomic fit, shape and size of implants; selection of biomaterials; instrumentation for surgical implantation procedures; preclinical testing for safety and efficacy, including risk/benefit ratio assessment evaluation of clinical performance and design of clinical trials. | This design course targets the solution of clinical problems by use of implants and other medical devices. Topics include the systematic use of cell-matrix control volumes; the role of stress analysis in the design process; anatomic fit, shape and size of implants; selection of biomaterials; instrumentation for surgical implantation procedures; preclinical testing for safety and efficacy, including risk/benefit ratio assessment evaluation of clinical performance and design of clinical trials. |
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| __Selected Lecture Notes__: | __Selected Lecture Notes__: |
| (http://ocw.mit.edu/OcwWeb/Mechanical-Engineering/2-782JSpring-2006/LectureNotes/index.htm) | (http://ocw.mit.edu/OcwWeb/Mechanical-Engineering/2-782JSpring-2006/LectureNotes/index.htm) |
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| __I. Principles Of Implant Design (Working Paradigms)__ | __I. Principles Of Implant Design (Working Paradigms)__ |
| {table} | {table} |
| Column1 | Column2 | Column3 | Column4 | Column5 | Column6 | Column1 | Column2 | Column3 | Column4 | Column5 | Column6 |
| Clinical Problems Requiring Implants for Solution|Principles of Implant Design / Design Parameters: Permanent versus Absorbable Devices|The Missing Organ and its Replacement|Criteria for Materials Selection|Tissue Engineering I: Scaffolds|Tissue Engineering II: Cells and Regulators | Clinical Problems Requiring Implants for Solution|Principles of Implant Design / Design Parameters: Permanent versus Absorbable Devices|The Missing Organ and its Replacement|Criteria for Materials Selection|Tissue Engineering I: Scaffolds|Tissue Engineering II: Cells and Regulators |
| Case Study of Organ Regeneration||||| | Case Study of Organ Regeneration||||| |
| {table} | {table} |
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| __II. Design Parameters__ | __II. Design Parameters__ |
| {table} | {table} |
| Column1 | Column2 | Column3 | Column4 | Column5 | Column6 | Column1 | Column2 | Column3 | Column4 | Column5 | Column6 |
| Design Specifications: Biomaterials Survey|Biocompatibility: Local and Systemic Effects|Design Specifications: Tissue Bonding and Modulus Matching|Degradation of Devices: Natural and Synthetic Polymers|Biocompatibility: Scar Formation and Contraction|Degradation of Devices: Corrosion and Wear | Design Specifications: Biomaterials Survey|Biocompatibility: Local and Systemic Effects|Design Specifications: Tissue Bonding and Modulus Matching|Degradation of Devices: Natural and Synthetic Polymers|Biocompatibility: Scar Formation and Contraction|Degradation of Devices: Corrosion and Wear |
| Federal Regulation of Devices I|Oral Presentations of Proposals for Design II|Federal Regulation of Devices II||| | Federal Regulation of Devices I|Oral Presentations of Proposals for Design II|Federal Regulation of Devices II||| |
| {table} | {table} |
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| __III. Design Solution In-use__ | __III. Design Solution In-use__ |
| {table} | {table} |
| Column1 | Column2 | Column3 | Column4 | Column5 | Column6 | Column1 | Column2 | Column3 | Column4 | Column5 | Column6 |
| Scaffolds for Cartilage Repair|Implants for Bone|Implants for Plastic Surgery|Cardiovascular Prostheses: Heart Valves and Blood Vessels|Devices for Nerve Regeneration|Musculoskeletal Soft Tissues: Meniscus, Intervertebral Disk | Scaffolds for Cartilage Repair|Implants for Bone|Implants for Plastic Surgery|Cardiovascular Prostheses: Heart Valves and Blood Vessels|Devices for Nerve Regeneration|Musculoskeletal Soft Tissues: Meniscus, Intervertebral Disk |
| Dental and Otologic Implants|Other Devices: Spinal Cord, Heart Lung|Final Oral Presentation of Designs (Mock FDA Panel)||| | Dental and Otologic Implants|Other Devices: Spinal Cord, Heart Lung|Final Oral Presentation of Designs (Mock FDA Panel)||| |
| {table} | {table} |
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| h3 Molecular Principles of Biomaterials | h3 Molecular Principles of Biomaterials |
| (http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-462JSpring-2006/CourseHome/index.htm) | (http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-462JSpring-2006/CourseHome/index.htm) |
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| __Course Description__: | __Course Description__: |
| This course covers the analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces. | This course covers the analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces. |
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| __Selected Lecture Notes__: | __Selected Lecture Notes__: |
| (http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-462JSpring-2006/LectureNotes/index.htm) | (http://ocw.mit.edu/OcwWeb/Biological-Engineering/20-462JSpring-2006/LectureNotes/index.htm) |
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| {table} | {table} |
| Column1 | Column2 | Column3 | Column4 | Column5 | Column6 | Column1 | Column2 | Column3 | Column4 | Column5 | Column6 |
| Biodegradable Polymeric Solids|Biodegradable Polymeric Solids|Controlled Release Devices|Controlled Release Devices (cont.)|Case Studies in Complex Controlled Release|Hydrogels as Biomaterials | Biodegradable Polymeric Solids|Biodegradable Polymeric Solids|Controlled Release Devices|Controlled Release Devices (cont.)|Case Studies in Complex Controlled Release|Hydrogels as Biomaterials |
| Hydrogels as Biomaterials (cont.)|Hydrogels as Biomaterials (cont.)|Hydrogels as Biomaterials (cont.)|Hydrogels as Biomaterials (cont.)|Engineering Biological Recognition of Biomaterials|Engineering Biological Recognition of Biomaterials (cont.) | Hydrogels as Biomaterials (cont.)|Hydrogels as Biomaterials (cont.)|Hydrogels as Biomaterials (cont.)|Hydrogels as Biomaterials (cont.)|Engineering Biological Recognition of Biomaterials|Engineering Biological Recognition of Biomaterials (cont.) |
| Engineering Biological Recognition of Biomaterials (cont.)|Bioceramics and Biocomposites|Bioceramics and Biocomposites (cont.)|Bioceramics and Biocomposites (cont.)|Molecular Devices|Nanoparticle and Microparticle Biomolecule Drug Carriers | Engineering Biological Recognition of Biomaterials (cont.)|Bioceramics and Biocomposites|Bioceramics and Biocomposites (cont.)|Bioceramics and Biocomposites (cont.)|Molecular Devices|Nanoparticle and Microparticle Biomolecule Drug Carriers |
| Nanoparticle and Microparticle Biomolecule Drug Carriers (cont.)|Basic Biology of Vaccination and Viral Infections|Basic Biology of Vaccination and Viral Infections (cont.)|Drug Targeting and Intracellular Drug Delivery for Vaccines|Drug Targeting and Intracellular Drug Delivery for Vaccines (cont.)|DNA Vaccines | Nanoparticle and Microparticle Biomolecule Drug Carriers (cont.)|Basic Biology of Vaccination and Viral Infections|Basic Biology of Vaccination and Viral Infections (cont.)|Drug Targeting and Intracellular Drug Delivery for Vaccines|Drug Targeting and Intracellular Drug Delivery for Vaccines (cont.)|DNA Vaccines |
| DNA Vaccines (cont.)||||| | DNA Vaccines (cont.)||||| |
| {table} | {table} |
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| | h2 Biology |
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| | h3 Genetics |
| | (http://ocw.mit.edu/OcwWeb/Biology/7-03Fall-2004/CourseHome/index.htm) |
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| | __Course Description__: |
| | This course discusses the principles of genetics with application to the study of biological function at the level of molecules, cells, and multicellular organisms, including humans. The topics include: structure and function of genes, chromosomes and genomes, biological variation resulting from recombination, mutation, and selection, population genetics, use of genetic methods to analyze protein function, gene regulation and inherited disease. |
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| | __Lecture Notes__: |
| | (http://ocw.mit.edu/OcwWeb/Biology/7-03Fall-2004/LectureNotes/index.htm) |
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| | {table} |
| | Column1 | Column2 | Column3 | Column4 | Column5 | Column6 |
| | Physical Structure of the Gene|The Complementation Test and Gene Function|Mendelian Genetics|Probability and Pedigrees|Chromosomes and Sex Linkage|Recombination and Genetic Maps |
| | Three-factor Crosses|Tetrad Analysis|Phage Genetics|Gene Structure and DNA Analysis|Mutations and Suppressors|Bacterial Genetics: Transposition |
| | Bacterial Genetics: Transduction|Complementation in Bacteria: Plasmids|Complementation in Bacteria: Recombinant DNA|Prokaryotic Regulation: Negative Control|Prokaryotic Regulation: Positive Control|Prokaryotic Regulation: Regulatory Circuits |
| | Eukaryotic Genes and Genomes I|Eukaryotic Genes and Genomes II|Eukaryotic Genes and Genomes III|Eukaryotic Genes and Genomes IV|Transgenes and Gene Targeting in Mice I|Transgenes and Gene Targeting in Mice II |
| | Population Genetics: Hardy-Weinberg|Population Genetics: Mutation and Selection|Population Genetics: Inbreeding|Human Polymorphisms|Statistical Evaluation of Linkage I|Statistical Evaluation of Linkage II |
| | Complex Traits|Chromosome Anomalies I|Chromosome Anomalies II|Genetics of Cancer I|Genetics of Cancer II|| |
| | {table} |