|

Entrez | PubMed | Nucleotide | Protein | Genome | Structure | OMIM | PMC | Journals | Books

Search
PubMed

Protein

Nucleotide

Structure

Genome

Books

CancerChromosomes

Conserved Domains

3D Domains

Gene

GEO Profiles

GEO DataSets

HomoloGene

Journals

MeSH

NCBI Web Site

OMIM

PMC

PopSet

SNP

Taxonomy

UniGene

UniSTS
for

| Limits | Preview/Index | History | Clipboard | Details | |

About Entrez

Text Version

Entrez PubMed
Overview
Help | FAQ
Tutorial
New/Noteworthy
E-Utilities

PubMed Services
Journals Database
MeSH Database
Single Citation Matcher
Batch Citation Matcher
Clinical Queries
LinkOut
Cubby

Related Resources
Order Documents
NLM Gateway
TOXNET
Consumer Health
Clinical Alerts
ClinicalTrials.gov
PubMed Central

Summary

Brief

Abstract

Citation

ASN.1

MEDLINE

XML

UI List

LinkOut

Related Articles

Cited in Books

CancerChrom Links

Domain Links

3D Domain Links

GEO DataSet Links

Gene Links

Genome Links

GEO Profile Links

HomoloGene Links

Nucleotide Links

OMIM Links

PMC Links

Cited in PMC

PopSet Links

Protein Links

SNP Links

Structure Links

UniSTS Links
Show:
5

10

20

50

100

200

500

Sort

Author

Journal

Pub Date

Text

File

Clipboard

E-mail

Order

1: J Allergy Clin Immunol. 1989 Mar;83(3):619-26. | Related Articles, Books, LinkOut

Pulmonary effects of sulfur dioxide exposure and ipratropium bromide pretreatment in adults with nonallergic asthma.

McManus MS, Koenig JQ, Altman LC, Pierson WE.

Department of Environmental Health, University of Washington, Seattle.

In this study we examined the potential short-term effect of sulfur dioxide (SO2) on total respiratory resistance and forced expiratory volume in patients with nonallergic asthma. A group of nine adult subjects with nonallergic asthma, 55 years of age or older, were exposed to SO2 at 0, 0.5, and 1.0 ppm for 20 minutes at rest followed by 10 minutes during light-moderate exercise. The measures of pulmonary function assessed were FEV1, specific total respiratory resistance (SRT), and maximal expiratory flow rates at 50% (Vmax50) and 75% (Vmax75) of expired vital capacity. Measurements were made before exposure to SO2 (baseline), postresting exposure, postexercising exposure, and at 30 minutes thereafter (recovery). Repeat measure analysis of variance revealed a statistically significant dose-response effect of SO2 inhalation on FEV1 (p = 0.008), SRT (p = 0.033), Vmax50 (p = 0.017), and Vmax75 (p = 0.048). Eight subjects had repeat exposure to SO2 at 1.0 ppm after treatment with either placebo or ipratropium bromide, 60 micrograms by metered-dose inhaler. Inpratropium bromide treatment, compared to placebo treatment, resulted in a statistically significant improvement in all baseline measures of pulmonary function: FEV1 (p = 0.017), SRT (p = 0.027), Vmax50 (p = 0.018), and Vmax75 (p = 0.035). However, this drug did not significantly alter the proportionate change in pulmonary function caused by SO2 inhalation in these subjects. These findings indicate that adults with nonallergic asthma are sensitive to short-term low-level SO2 exposure and that treatment with 60 micrograms of ipratropium bromide causes significant bronchodilation but does not protect, completely, these patients from the effect of SO2 inhalation.

Publication Types:

Clinical Trial
Controlled Clinical Trial
Randomized Controlled Trial

PMID: 2522475 [PubMed - indexed for MEDLINE]

Summary

Brief

Abstract

Citation

ASN.1

MEDLINE

XML

UI List

LinkOut

Related Articles

Cited in Books

CancerChrom Links

Domain Links

3D Domain Links

GEO DataSet Links

Gene Links

Genome Links

GEO Profile Links

HomoloGene Links

Nucleotide Links

OMIM Links

PMC Links

Cited in PMC

PopSet Links

Protein Links

SNP Links

Structure Links

UniSTS Links
Show:
5

10

20

50

100

200

500

Sort

Author

Journal

Pub Date

Text

File

Clipboard

E-mail

Order

| |

Write to the Help Desk
NCBI | NLM | NIH
Department of Health & Human Services
Privacy Statement | Freedom of Information Act | Disclaimer

Jul 27 2004 06:47:37