Module 3: Toxicology - Section 3: Linking Chemical Exposures and Health Effects |
TOX 3.1: Overview |
OBJECTIVES |
By the end of this module: 1. You will be familiar in detail with how to make the link between exposure to hazardous chemical substances and adverse health effects 2. You should be familiar with the factors determining exposure to hazardous chemical substances and how to assess this objectively 3. You should be familiar with the mechanisms of disease causation and how to assess health effects to specific body systems |
EXERCISE:
The factory visit will be used as the exercise. Please see the semester menu.
REFERENCES:
1. Stanton D, Jeebhay MF. Chemical hazards. In Guild R, Ehrlich RI, Johnston JR, Ross MH, eds. Handbook of Occupational Health Practice in the South African Mining Industry, 1st edition, Johannesburg, South Africa, Safety In Mines Research Advisory Committee (SIMRAC), 2001;257-293.
2. For detailed toxicology and adverse health effects information refer to:
· Patty’s Industrial Hygiene and Toxicology.
·
NIOSH
Occupational Health guidelines
for chemical hazards or the
      NIOSH
Pocket Guide to Chemical
Hazards.
· ILO Encyclopedia of Occupational Health and Safety.
· International Agency for Research on Cancer (IARC) Cancer Databases.
3. For detailed methodology on
sampling procedures for biological monitoring and information on BEI for a
particular
substance refer to:
· ACGIH publication - Documentation of the Threshold Limit Values and Biological Exposure Indices
4. For information on biological monitoring tests indicated for individual substances refer to:
·
NIOSH
database on Specific Medical Tests Published in the Literature for OSHA
Regulated Substances
5. Important links to information
have been added to the Chemicals, OELs, MSDS, Transport, Mining and Online
Training
pages (World Links) of ASOSH.ORG.
Postgraduate Diploma in Occupational Health (DOH) - Modules 3: Occupational Medicine & Toxicology (Basic) by Profs Mohamed Jeebhay and Rodney Ehrlich, Health Sciences UCT is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 2.5 South Africa License. Major contributors: Mohamed Jeebhay, Rodney Ehrlich, Jonny Myers, Leslie London, Sophie Kisting, Rajen Naidoo, Saloshni Naidoo. Source available from here. For any updates to the material, or more permissions beyond the scope of this license, please email healthoer@uct.ac.za or visit www.healthedu.uct.ac.za.
Last updated Jan 2007.
Disclaimer note: Some resources and descriptions may be out-dated. For suggested updates and feedback, please contact healthoer@uct.ac.za.