Module 3: Toxicology - Section 3: Linking Chemical Exposures and Health Effects
TOX 3.1: Overview

OBJECTIVES

By the end of this module: 

1.        You will be familiar in detail with how to make the link between exposure to hazardous chemical substances and adverse health effects

2.        You should be familiar with  the factors determining exposure to hazardous chemical substances and how to assess this objectively

3.        You should be familiar with the mechanisms of disease causation and how to assess health effects to specific body systems

This introductory page contains links to other pages in this section. These are included for your convenience, both for reference and for revision purposes. It is strongly recommended, however, that you first access the material in its logical sequence, indicated by the "Next Page" link above. 

ACTIVITIES

  1. A lecture will provide the overview.
  2. Factory visit.

EXERCISE:

The factory visit will be used as the exercise. Please see the semester menu. 

REFERENCES: 

1. Stanton D, Jeebhay MF. Chemical hazards. In Guild R, Ehrlich RI, Johnston JR, Ross MH, eds. Handbook of Occupational Health Practice in the South African Mining Industry, 1st edition, Johannesburg, South Africa, Safety In Mines Research Advisory Committee (SIMRAC), 2001;257-293.

2. For detailed toxicology and adverse health effects information refer to:

·         Patty’s Industrial Hygiene and Toxicology.

·         NIOSH Occupational Health guidelines for chemical hazards  or the
      NIOSH Pocket Guide to Chemical Hazards.

·         ILO Encyclopedia of Occupational Health and Safety.

·         International Agency for Research on Cancer (IARC) Cancer Databases.

3. For detailed methodology on sampling procedures for biological monitoring and information on BEI for a particular
          substance refer to:

·         ACGIH publication - Documentation of the Threshold Limit Values and Biological Exposure Indices

4. For information on biological monitoring tests indicated for individual substances refer to:

·         NIOSH database on Specific Medical Tests Published in the Literature for OSHA Regulated Substances
                

5. Important links to information have been added to the Chemicals, OELs, MSDS, Transport, Mining and Online Training
                       pages (World Links) of ASOSH.ORG.



Creative Commons License
Postgraduate Diploma in Occupational Health (DOH) - Modules 3: Occupational Medicine & Toxicology (Basic) by Profs Mohamed Jeebhay and Rodney Ehrlich, Health Sciences UCT is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 2.5 South Africa License. Major contributors: Mohamed Jeebhay, Rodney Ehrlich, Jonny Myers, Leslie London, Sophie Kisting, Rajen Naidoo, Saloshni Naidoo. Source available from here. For any updates to the material, or more permissions beyond the scope of this license, please email healthoer@uct.ac.za or visit www.healthedu.uct.ac.za. Last updated Jan 2007.
Disclaimer note: Some resources and descriptions may be out-dated. For suggested updates and feedback, please contact healthoer@uct.ac.za.